Q5ZK33
Gene name |
LETM1 (RCJMB04_13i11) |
Protein name |
Mitochondrial proton/calcium exchanger protein |
Names |
Leucine zipper-EF-hand-containing transmembrane protein 1 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:422898 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZK33
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZK33-F1 | Predicted | AlphaFoldDB |
No variants for Q5ZK33
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5ZK33 | |||||
No associated diseases with Q5ZK33
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in). |
| ribosome binding | Binding to a ribosome. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium export from the mitochondrion | A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol. |
| cellular metal ion homeostasis | Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell. |
| mitochondrial calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. |
| mitochondrial calcium ion transmembrane transport | The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion. |
| protein hexamerization | The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits. |
| protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06493 | YLH47 | LETM1 domain-containing protein YLH47, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q0VCA3 | LETM1 | Mitochondrial proton/calcium exchanger protein | Bos taurus (Bovine) | PR |
| Q2VYF4 | LETM2 | LETM1 domain-containing protein LETM2, mitochondrial | Homo sapiens (Human) | PR |
| O95202 | LETM1 | Mitochondrial proton/calcium exchanger protein | Homo sapiens (Human) | PR |
| Q7TNU7 | Letm2 | LETM1 domain-containing protein LETM2, mitochondrial | Mus musculus (Mouse) | PR |
| Q9Z2I0 | Letm1 | Mitochondrial proton/calcium exchanger protein | Mus musculus (Mouse) | PR |
| Q5PQQ5 | Letm2 | LETM1 domain-containing protein LETM2, mitochondrial | Rattus norvegicus (Rat) | PR |
| Q5XIN6 | Letm1 | Mitochondrial proton/calcium exchanger protein | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLQSCGRRA | CRLPRALRRQ | APLGNLGDRA | CLSCTSLRLA | NKMTVHFKYC | TSVAPVYAYS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKDHYCCWTK | GLERTYFTLM | SSSGSWTPLA | AMGVLGPKYL | PVRWWHSSRS | LQDDSIVEKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKSLKDKNKK | LEEGGPVYSP | TEVEVVKKSI | GQRIVDELKH | YYHGFRLLWI | DTKIAARMLW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RILHGNTLSR | RERRQFLRIC | ADLFRLVPFL | VFLVVPFMEF | LLPVALKLFP | NMLPSTFETK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SKKEERLKKQ | LRVKLELAKF | LQDTIEEMAL | KNKAAKGNVT | KDFSTFFQKI | RETGERPSNE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EILRFSKLFE | DELTLDNLTR | PQLVALCKLL | ELQSIGTNNF | LRFQLTMRLR | TIKADDKMIA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EEGVDSLTVK | ELQAACRARG | MRALGVTEER | LREQLKQWLD | LHLNQEIPTS | LLILSRAMYL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PDTLSPADQL | KTTLQTLPES | VAKEAQVKVA | EVEGEKVDNK | ARLEATLQEE | AAIRKENEEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EMERITEAAE | KAKETLQVAA | MKLESAVDLE | PAVLQVKESQ | VAMDSKQELA | KADMETLKDT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| APVLEGIKGE | EITKEEIDML | SDACNKLQEQ | KKSLTKEKEE | LEELKGDIQE | YNEDLQEIKE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LSKAGQEEVV | EESKASKRLT | KRVNRMIGQI | DKIINELETN | QKTVDVKLDR | GDSPPAGENL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ISIAELINAM | KQIQKIPEEK | LTRIAEALDE | NKDGKIDIDN | VVKVVELIDK | EDVDIGTSQV |
| 730 | 740 | 750 | |||
| AEIMALLQKE | EKLEEKEKAK | EKQDKEAAEV | KN |