Q0VCA3

PR
Gene name
LETM1
Protein name
Mitochondrial proton/calcium exchanger protein
Names
Leucine zipper-EF-hand-containing transmembrane protein 1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:513324
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

70-160 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0VCA3

Entry ID Method Resolution Chain Position Source
AF-Q0VCA3-F1 Predicted AlphaFoldDB

No variants for Q0VCA3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0VCA3

No associated diseases with Q0VCA3

3 regional properties for Q0VCA3

Type Name Position InterPro Accession
domain EF-hand domain 656 - 691 IPR002048
binding_site EF-Hand 1, calcium-binding site 669 - 681 IPR018247
domain LETM1-like, ribosome-binding domain 177 - 529 IPR033122

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
calcium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).
ribosome binding Binding to a ribosome.

8 GO annotations of biological process

Name Definition
calcium export from the mitochondrion A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol.
cellular metal ion homeostasis Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell.
mitochondrial calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
mitochondrial calcium ion transmembrane transport The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
negative regulation of mitochondrial calcium ion concentration Any process that decreases the concentration of calcium ions in mitochondria.
protein hexamerization The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of cellular hyperosmotic salinity response Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06493 YLH47 LETM1 domain-containing protein YLH47, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A3KN46 LETMD1 LETM1 domain-containing protein 1 Bos taurus (Bovine) PR
Q5ZK33 LETM1 Mitochondrial proton/calcium exchanger protein Gallus gallus (Chicken) PR
Q2VYF4 LETM2 LETM1 domain-containing protein LETM2, mitochondrial Homo sapiens (Human) PR
O95202 LETM1 Mitochondrial proton/calcium exchanger protein Homo sapiens (Human) PR
Q7TNU7 Letm2 LETM1 domain-containing protein LETM2, mitochondrial Mus musculus (Mouse) PR
Q9Z2I0 Letm1 Mitochondrial proton/calcium exchanger protein Mus musculus (Mouse) PR
Q5PQQ5 Letm2 LETM1 domain-containing protein LETM2, mitochondrial Rattus norvegicus (Rat) PR
Q5XIN6 Letm1 Mitochondrial proton/calcium exchanger protein Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MASILLRSCR GRGPARLPPP RSAAPRGPAG DLACLSGASA VGLMSYVPLP LGSCAPVRPV
70 80 90 100 110 120
YLSLRADPLG CWTLRPKRAC AVLAGPRLLP VRCWHSSRPL GDDSVVEKSL RSLKDKNKKL
130 140 150 160 170 180
EEGGPVYSPP AQAAVRKPLG QRVLDELRHY YHGFRLLWID TKIAARMLWR ILHGHSLTRR
190 200 210 220 230 240
ERRQFLRICA DLFRLVPFLF FVVVPFMEFL LPVAVKLFPN MLPSTFETQS SKEERLKKEL
250 260 270 280 290 300
RVKLELAKFL QDTIEEMALK NKAAKGSATK DFSVFFQKIR ETGERPSNEE IMRFSKLFED
310 320 330 340 350 360
ELTLDNLTRP QLVALCKLLE LQSIGTNNFL RFQLTMRLRS IKADDKLIAE EGVDSLNVKE
370 380 390 400 410 420
LQAACRARGM RALGVTEDRL RGQLKQWLEL HLHQEIPTSL LILSRAMYLP ETLSPADQLK
430 440 450 460 470 480
STLQTLPEIV AKEAQVKVAE VEGEQVDNKA KLEATLQEEA AIQQEHREKE LQRKSQAAVA
490 500 510 520 530 540
QAAKEVEPEV VAEGAPGRPV AELQPEEPAV TLPSEVLKDS APVLEGLKEE EITQEEIDVL
550 560 570 580 590 600
SNACSKLKEQ KKSLTKEKEE LELLKGDVQD YSQDLQEIKK ELSKTGEEMY VEESKASKRL
610 620 630 640 650 660
TKRVQQMIGQ MDSLLAQLEA DQKAGRLGPA AEAAPAGETV ISVSELINAM KQIKHIPESK
670 680 690 700 710 720
LLSLASALDD NKDGKVDIDD LVKVIELVDK EDVHISTSQV AEIVATLEKE EKVEEKEKAK
730
EKAEKEAAEV QN