Q9Z2I0
PR
Gene name |
Letm1 |
Protein name |
Mitochondrial proton/calcium exchanger protein |
Names |
Leucine zipper-EF-hand-containing transmembrane protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56384 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z2I0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z2I0-F1 | Predicted | AlphaFoldDB |
35 variants for Q9Z2I0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs241452463 | 10 | R>W | No | EVA | |
| rs3388728002 | 30 | R>K | No | EVA | |
| rs47584358 | 38 | T>N | No | EVA | |
| rs3388754796 | 39 | R>S | No | EVA | |
| rs3388747851 | 40 | T>S | No | EVA | |
| rs3388737951 | 45 | S>T | No | EVA | |
| rs3388755699 | 69 | L>I | No | EVA | |
| rs3388747420 | 114 | G>E | No | EVA | |
| rs3388755393 | 122 | S>Y | No | EVA | |
| rs3388752297 | 212 | L>M | No | EVA | |
| rs3388747861 | 268 | E>D | No | EVA | |
| rs3388757080 | 307 | F>S | No | EVA | |
| rs3388744635 | 353 | S>F | No | EVA | |
| rs3388744672 | 356 | A>V | No | EVA | |
| rs3395351700 | 368 | S>I | No | EVA | |
| rs3395369479 | 368 | S>R | No | EVA | |
| rs3395369430 | 370 | T>P | No | EVA | |
| rs3395186374 | 376 | A>S | No | EVA | |
| rs3388754933 | 379 | R>G | No | EVA | |
| rs3388761013 | 379 | R>Q | No | EVA | |
| rs3388757065 | 380 | A>G | No | EVA | |
| rs3413032844 | 417 | S>F | No | EVA | |
| rs50883858 | 502 | L>V | No | EVA | |
| rs3388754813 | 512 | P>A | No | EVA | |
| rs3388749871 | 513 | P>L | No | EVA | |
| rs3388754985 | 532 | E>* | No | EVA | |
| rs3388754930 | 538 | E>K | No | EVA | |
| rs3388755332 | 553 | K>M | No | EVA | |
| rs3388754807 | 611 | V>M | No | EVA | |
| rs3388761059 | 640 | T>S | No | EVA | |
| rs3388754954 | 643 | G>W | No | EVA | |
| rs50750241 | 668 | I>L | No | EVA | |
| rs3388749883 | 673 | A>S | No | EVA | |
| rs3388752248 | 683 | N>S | No | EVA | |
| rs250633616 | 717 | E>G | No | EVA |
No associated diseases with Q9Z2I0
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in). |
| metal ion binding | Binding to a metal ion. |
| ribosome binding | Binding to a ribosome. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium export from the mitochondrion | A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol. |
| cellular metal ion homeostasis | Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell. |
| cristae formation | The assembly of cristae, the inwards folds of the inner mitochondrial membrane. |
| mitochondrial calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. |
| mitochondrial calcium ion transmembrane transport | The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion. |
| negative regulation of mitochondrial calcium ion concentration | Any process that decreases the concentration of calcium ions in mitochondria. |
| protein hexamerization | The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits. |
| protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| regulation of cellular hyperosmotic salinity response | Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06493 | YLH47 | LETM1 domain-containing protein YLH47, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q0VCA3 | LETM1 | Mitochondrial proton/calcium exchanger protein | Bos taurus (Bovine) | PR |
| Q5ZK33 | LETM1 | Mitochondrial proton/calcium exchanger protein | Gallus gallus (Chicken) | PR |
| Q2VYF4 | LETM2 | LETM1 domain-containing protein LETM2, mitochondrial | Homo sapiens (Human) | PR |
| O95202 | LETM1 | Mitochondrial proton/calcium exchanger protein | Homo sapiens (Human) | PR |
| Q7TNU7 | Letm2 | LETM1 domain-containing protein LETM2, mitochondrial | Mus musculus (Mouse) | PR |
| Q924L1 | Letmd1 | LETM1 domain-containing protein 1 | Mus musculus (Mouse) | PR |
| Q5PQQ5 | Letm2 | LETM1 domain-containing protein LETM2, mitochondrial | Rattus norvegicus (Rat) | PR |
| Q5XIN6 | Letm1 | Mitochondrial proton/calcium exchanger protein | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASILLRSCR | GRGPARLAPP | RAASPRGSLR | DRACLSCTRT | LGLTSRESVL | SRCCTPAHPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YLCFKGEPLS | CWTQRPECQG | TAARTTWTPA | SARLVVTGPQ | YLPVRGWHSS | SPLGEDSVIE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KSLKSLKDKN | KKLEEGGPVY | SPPAQVVVRK | SLGQKVLDEL | RHYYHGFRLL | WIDTKIAARM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LWRILNGHTL | TRRERRQFLR | ICADLFRLVP | FLVFVVVPFM | EFLLPVVVKL | FPNMLPSTFE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TQSIKEERLK | KELRVKLELA | KFLQDTIEEM | ALKNKAAKGN | ATKDFSAFFQ | KIRETGERPS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NEEIMRFSKL | FEDELTLDNL | TRPQLVALCK | LLELQSIGTN | NFLRFQLTMR | LRSIKADDKL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ISEEGVDSLT | VKELQAACRA | RGMRALGVTE | DRLKGQLKQW | LDLHLHHEIP | TSLLILSRAM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YLPDTLSPAD | QLKSTLQTLP | EIVAKEAQVK | VAEVEGEKVD | NKAKLEATLQ | EEAAIQQEHL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EELKRASEAV | KDIQPEVAEA | TLPGRPGPEP | QPPVDDVILP | SEVLTDTAPV | LEGLKGEEIT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KEEIDILSDA | CSKLQEQKKS | LTKEKEELEL | LKEDVQDYSE | DLQEIKKELS | KTGEEKYIEE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SAASKRLSKR | VQQMIGQIDG | LITQLETTQQ | DGKLGPSQST | PTGESVISIT | ELISAMKQIK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HIPEHKLISL | TSALDDNKDG | NINIDDLVKV | IDLVNKEDVQ | ISTTQVAEIV | ATLEKEEKIE |
| 730 | |||||
| EKEKAKEKAE | KEAAEVKN |