Q7TNU7

PR
Gene name
Letm2
Protein name
LETM1 domain-containing protein LETM2, mitochondrial
Names
LETM1 and EF-hand domain-containing protein 2, Leucine zipper-EF-hand-containing transmembrane protein 1-like
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:270035
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

66-135 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7TNU7

Entry ID Method Resolution Chain Position Source
AF-Q7TNU7-F1 Predicted AlphaFoldDB

8 variants for Q7TNU7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388977451 173 V>I No EVA
rs250904799 198 L>F No EVA
rs3388974318 213 K>R No EVA
rs3388978019 214 E>A No EVA
rs3410427072 233 E>D No EVA
rs3388947173 314 L>H No EVA
rs3388969676 338 V>M No EVA
rs3388970061 347 A>E No EVA

No associated diseases with Q7TNU7

2 regional properties for Q7TNU7

Type Name Position InterPro Accession
domain LETM1-like, ribosome-binding domain 158 - 436 IPR033122
domain LETM2, N-terminal 1 - 109 IPR045742

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

1 GO annotations of molecular function

Name Definition
ribosome binding Binding to a ribosome.

1 GO annotations of biological process

Name Definition
cellular metal ion homeostasis Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06493 YLH47 LETM1 domain-containing protein YLH47, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q0VCA3 LETM1 Mitochondrial proton/calcium exchanger protein Bos taurus (Bovine) PR
Q5ZK33 LETM1 Mitochondrial proton/calcium exchanger protein Gallus gallus (Chicken) PR
O95202 LETM1 Mitochondrial proton/calcium exchanger protein Homo sapiens (Human) PR
Q2VYF4 LETM2 LETM1 domain-containing protein LETM2, mitochondrial Homo sapiens (Human) PR
Q9Z2I0 Letm1 Mitochondrial proton/calcium exchanger protein Mus musculus (Mouse) PR
Q924L1 Letmd1 LETM1 domain-containing protein 1 Mus musculus (Mouse) PR
Q5XIN6 Letm1 Mitochondrial proton/calcium exchanger protein Rattus norvegicus (Rat) PR
Q5PQQ5 Letm2 LETM1 domain-containing protein LETM2, mitochondrial Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAFYSYNSFL AIFWTRLPGH SVYPSCSHFP SLAFLHLPDS HLRTAYIKNC GSRKYSYPSL
70 80 90 100 110 120
TGNNKVHPLR TRLPQKLHTT CWLQHVPGKP QLEQTGKPKA ASPQPTKEAK TETTEEKRSL
130 140 150 160 170 180
RQKIVNELKY YYKGFSLLWI DTKVAARIVW RLLHGNALTR RERRRLLRTC ADVFRLVPFM
190 200 210 220 230 240
VFIIVPFMEF LIPVFLKLFP DMLPSTFESE SKKEEKQKKT MAAKLEIAKF LQETMTEMAR
250 260 270 280 290 300
RNRAKLGDAS SQLSSYVKQV QTGHKPSTKE IVRFSKLFKD QLALEHLDRP QLVALCKLLE
310 320 330 340 350 360
LQTFGTNNLL RFQLLMTLKS IKADDEIIAK EGVKALSVSE LQSACRARGM RSLGLTEEQL
370 380 390 400 410 420
CQQLTGWLDL HLKENVPPSL LLLSRTFYLI DVKPKPIELP PNIETPKPNL GIPTPPPPES
430 440 450 460 470
KENLTDSAPQ LKGTKDEEFI QLPPVPSSLI APAATISKEA ILQAKSQETS QNSKADSKGA