Q2VYF4
PR
Gene name |
LETM2 |
Protein name |
LETM1 domain-containing protein LETM2, mitochondrial |
Names |
LETM1 and EF-hand domain-containing protein 2, Leucine zipper-EF-hand-containing transmembrane protein 1-like |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:137994 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2VYF4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2VYF4-F1 | Predicted | AlphaFoldDB |
402 variants for Q2VYF4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs769324819 CA4717592 |
2 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA4717593 rs373615661 |
3 | F>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA370713094 rs1295820672 |
4 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1046984697 CA175120204 |
5 | S>N | No |
ClinGen Ensembl |
|
|
rs1002833768 CA175120223 |
9 | V>A | No |
ClinGen Ensembl |
|
|
rs1018464274 CA175120227 |
13 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
CA370713157 rs1286014810 |
14 | R>* | No |
ClinGen gnomAD |
|
|
rs749773573 CA370713158 |
14 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717594 rs749773573 |
14 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370713170 rs1228670045 |
16 | R>I | No |
ClinGen gnomAD |
|
|
CA4717610 rs754025929 |
17 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717614 rs754749299 |
23 | H>N | No |
ClinGen ExAC gnomAD |
|
|
rs1471821066 CA370715397 |
25 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA370715368 rs1296274153 |
25 | T>P | No |
ClinGen TOPMed |
|
|
CA370715565 rs780856797 |
31 | P>A | No |
ClinGen ExAC gnomAD |
|
|
CA4717615 rs780856797 |
31 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs752260399 CA4717616 CA370715605 |
32 | S>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs949369805 CA175122014 |
33 | C>R | No |
ClinGen Ensembl |
|
| TCGA novel | 34 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1370259371 CA370715740 |
36 | L>R | No |
ClinGen TOPMed |
|
| TCGA novel | 36 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs755813998 CA4717617 |
39 | P>L | No |
ClinGen ExAC |
|
|
rs777252041 CA4717618 |
40 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs748865530 CA4717619 |
41 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1333039267 CA370715866 |
42 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs779305461 CA4717621 |
44 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs746197557 CA4717623 |
47 | C>R | No |
ClinGen ExAC TOPMed |
|
|
rs1284271910 CA370716027 |
48 | M>I | No |
ClinGen gnomAD |
|
|
CA370716020 rs1431895702 |
48 | M>R | No |
ClinGen TOPMed |
|
|
CA175122064 rs200086755 |
49 | K>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA370716073 rs1299744136 |
51 | Y>* | No |
ClinGen gnomAD |
|
|
CA370716069 rs1226012392 |
51 | Y>C | No |
ClinGen gnomAD |
|
|
rs772359023 CA4717624 |
51 | Y>N | No |
ClinGen ExAC gnomAD |
|
|
CA175122067 rs1055824678 |
52 | E>* | No |
ClinGen TOPMed gnomAD |
|
|
CA370716075 rs1055824678 |
52 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs775966942 CA4717625 |
53 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1338612073 CA370716122 |
54 | K>E | No |
ClinGen gnomAD |
|
|
CA4717626 rs144305067 |
57 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs148738728 CA4717628 |
59 | P>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4717629 rs372275125 |
62 | P>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs766289460 CA4717630 |
64 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs537786240 CA175122103 |
64 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717632 rs542290756 |
65 | T>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA370716417 rs1172327760 |
66 | V>L | No |
ClinGen gnomAD |
|
|
CA370716433 rs1405684388 |
67 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs752547527 CA4717634 |
69 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA175122107 rs958590715 |
69 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs755759012 CA4717635 |
71 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs777409697 CA4717636 |
74 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA370716578 rs1432306427 |
75 | Q>* | No |
ClinGen gnomAD |
|
|
rs1020894480 CA175122113 |
79 | T>I | No |
ClinGen Ensembl |
|
|
rs376807655 CA4717637 |
80 | S>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA370716722 rs1585980362 |
82 | C>R | No |
ClinGen Ensembl |
|
|
CA4717640 rs746333592 |
86 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA4717639 rs779438461 |
86 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1221095742 CA370716920 |
89 | G>V | No |
ClinGen gnomAD |
|
|
CA175122126 rs1021399195 |
91 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
CA370716967 rs1263995067 |
92 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs997801460 CA175122128 |
92 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA370716988 rs1206879245 |
94 | E>K | No |
ClinGen gnomAD |
|
|
rs199547470 CA175122132 |
95 | Q>K | No |
ClinGen Ensembl |
|
|
rs1029966464 CA175122133 |
99 | H>R | No |
ClinGen TOPMed |
|
|
CA4717641 rs772688230 |
101 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
CA370717128 rs1212031824 |
102 | V>M | No |
ClinGen gnomAD |
|
|
rs1480508627 CA370717164 |
103 | T>R | No |
ClinGen TOPMed |
|
|
rs780273690 CA4717642 |
104 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA4717643 rs369522263 |
104 | S>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 105 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1376227478 CA370717216 |
106 | Q>* | No |
ClinGen gnomAD |
|
|
CA370717212 rs1376227478 |
106 | Q>K | No |
ClinGen gnomAD |
|
|
rs768939911 CA175122134 |
113 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768939911 CA4717644 |
113 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370717347 rs777013953 |
114 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA4717645 rs777013953 |
114 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs769731386 CA4717647 |
115 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs773388994 CA4717648 |
116 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs767558652 CA4717650 |
117 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA4717649 rs759379631 |
117 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs1332537259 CA370717473 |
120 | Q>P | No |
ClinGen gnomAD |
|
|
CA4717651 rs752424957 |
121 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs752424957 CA370717512 |
121 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA4717652 rs760477930 |
122 | Y>H | Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 122 | Y>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370717575 rs1439116990 |
124 | Q>* | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 126 | I>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs150983987 CA4717655 |
126 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA370717652 rs1351513832 |
127 | M>T | No |
ClinGen gnomAD |
|
|
CA370717645 COSM1285911 COSM1285912 rs1585980862 |
127 | M>V | autonomic_ganglia [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA4717658 rs764635159 |
131 | K>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717659 rs750011845 |
134 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
rs1200578196 CA370717773 |
134 | Y>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1471400987 CA370717790 |
135 | N>D | No |
ClinGen TOPMed gnomAD |
|
|
rs758760494 CA4717660 |
135 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1338009683 CA370717810 |
136 | G>E | No |
ClinGen TOPMed |
|
|
rs1363809093 CA370717819 |
137 | F>L | No |
ClinGen gnomAD |
|
|
CA370717830 rs1457142652 |
137 | F>L | No |
ClinGen TOPMed |
|
|
CA581431035 rs1563386105 |
138 | Y>* | No |
ClinGen Ensembl |
|
|
CA4717661 rs780716788 |
138 | Y>C | No |
ClinGen ExAC TOPMed |
|
|
rs780716788 CA370717840 |
138 | Y>S | No |
ClinGen ExAC TOPMed |
|
|
CA4717662 rs747325319 |
139 | L>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747325319 CA370717855 |
139 | L>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs375193498 CA4717664 |
141 | W>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs781718167 CA4717665 |
143 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs770111359 CA370717932 |
144 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770111359 CA4717667 |
144 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA175122182 rs981997582 |
145 | K>E | No |
ClinGen Ensembl |
|
|
CA4717668 rs773162729 |
145 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA4717669 rs749391639 |
146 | V>F | No |
ClinGen ExAC gnomAD |
|
|
CA4717670 rs749391639 |
146 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs976388655 CA175122193 |
147 | A>T | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 148 | A>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1204249199 CA370717963 |
149 | R>K | No |
ClinGen TOPMed |
|
|
rs1263813404 CA370717986 |
152 | W>* | No |
ClinGen gnomAD |
|
|
rs775430653 CA4717672 |
153 | R>M | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 154 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1585981387 CA370718019 |
155 | L>V | No |
ClinGen Ensembl |
|
|
CA370718041 rs1223968080 |
156 | H>P | No |
ClinGen gnomAD |
|
|
rs760426573 CA370718046 |
156 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
CA370718037 rs1223968080 |
156 | H>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA370718069 rs1482285171 |
158 | Q>R | No |
ClinGen gnomAD |
|
|
rs372850103 CA4717674 |
163 | R>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs776463175 CA4717675 |
163 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA4717676 rs574356512 |
166 | R>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4717677 rs764943977 |
166 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA370718182 rs1167899107 |
167 | R>M | No |
ClinGen gnomAD |
|
|
rs1408303275 CA370718583 |
174 | D>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1408303275 CA370718584 |
174 | D>G | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 175 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1037902290 CA175122631 |
177 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA4717693 rs374786773 |
177 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA370718667 rs374786773 |
177 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4717694 rs764745142 |
180 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA370718757 rs1311988479 |
182 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
CA4717695 rs772946645 |
183 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1264652902 CA370718805 |
184 | F>Y | No |
ClinGen gnomAD |
|
|
CA370718926 rs929614648 |
190 | M>L | No |
ClinGen TOPMed gnomAD |
|
|
rs929614648 CA175122644 |
190 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1429970291 CA370719029 |
193 | L>V | No |
ClinGen Ensembl |
|
|
CA175122648 rs531601752 |
195 | P>S | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
| TCGA novel | 199 | K>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370719215 rs1354609903 |
199 | K>R | No |
ClinGen TOPMed |
|
|
CA175122663 rs549663160 |
200 | L>V | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs1285329029 CA370719367 |
204 | M>I | No |
ClinGen TOPMed |
|
|
CA370719366 rs1266334566 |
204 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA370719450 rs762551516 |
208 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762551516 CA4717696 |
208 | T>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370719524 rs1325354194 |
211 | S>N | No |
ClinGen TOPMed |
|
|
CA175122668 rs1003206692 |
212 | E>D | No |
ClinGen TOPMed |
|
|
rs753535533 CA4717697 |
213 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA175122675 rs1016723565 |
214 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
rs1312024944 CA370721913 |
216 | E>A | No |
ClinGen gnomAD |
|
|
CA370721914 rs1312024944 |
216 | E>G | No |
ClinGen gnomAD |
|
|
rs1429552798 CA370721919 |
217 | E>* | No |
ClinGen gnomAD |
|
|
rs1429552798 CA370721918 |
217 | E>K | No |
ClinGen gnomAD |
|
|
CA4717721 rs762652799 |
219 | Q>* | No |
ClinGen ExAC |
|
|
CA175125130 rs762652799 |
219 | Q>K | No |
ClinGen ExAC |
|
|
CA370721944 rs1193631431 |
220 | K>R | No |
ClinGen gnomAD |
|
|
rs1251747722 CA370721948 |
221 | K>Q | No |
ClinGen TOPMed |
|
|
CA4717723 rs776843286 |
223 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs759132231 CA4717724 |
224 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs76995206 CA175125151 |
225 | V>G | No |
ClinGen Ensembl |
|
|
rs768090246 CA4717725 |
226 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA370722028 COSM169129 rs1203708860 |
232 | F>C | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA370722033 rs1315680993 |
233 | L>F | No |
ClinGen gnomAD |
|
| TCGA novel | 233 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4717728 rs761128959 |
234 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717727 rs761128959 |
234 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370722052 rs1202730381 |
236 | T>A | No |
ClinGen gnomAD |
|
|
rs968827885 CA175125179 |
237 | M>T | No |
ClinGen Ensembl |
|
|
rs1274901213 CA370722059 |
237 | M>V | No |
ClinGen gnomAD |
|
|
CA370722066 rs1252602286 |
238 | T>A | No |
ClinGen TOPMed |
|
|
rs958526848 CA175125185 |
238 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA370722088 rs1311276491 |
241 | A>P | No |
ClinGen TOPMed |
|
| TCGA novel | 242 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370722104 rs1236914429 |
243 | R>S | No |
ClinGen gnomAD |
|
|
rs1013162912 CA175125194 |
243 | R>T | No |
ClinGen TOPMed |
|
|
CA4717730 rs147445988 |
245 | R>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1185926240 CA370722126 |
247 | K>Q | No |
ClinGen gnomAD |
|
|
rs140611222 CA4717731 |
248 | M>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs933529350 CA175125198 |
249 | G>S | No |
ClinGen Ensembl |
|
|
CA370722150 rs1407959925 |
250 | D>G | No |
ClinGen TOPMed |
|
|
rs779116752 CA4717732 |
250 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA175125201 rs987754899 |
252 | S>A | No |
ClinGen Ensembl |
|
|
rs539486775 CA4717733 |
252 | S>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA4717735 rs201328621 |
253 | T>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA370722171 rs1454138281 |
254 | Q>* | No |
ClinGen gnomAD |
|
|
CA370722172 rs1298842021 |
254 | Q>P | No |
ClinGen TOPMed |
|
|
CA4717737 rs769676111 |
256 | S>A | No |
ClinGen ExAC gnomAD |
|
|
CA4717738 rs147828005 |
257 | S>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA370722192 rs147828005 |
257 | S>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA370722201 rs1339842427 |
259 | V>M | No |
ClinGen gnomAD |
|
|
rs956954561 CA175125263 |
261 | Q>E | No |
ClinGen TOPMed gnomAD |
|
|
CA4717742 rs774170105 |
261 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1205622513 CA370722219 |
261 | Q>P | No |
ClinGen TOPMed gnomAD |
|
|
CA4717762 rs775064904 |
262 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370722240 rs1160181078 |
263 | Q>* | No |
ClinGen gnomAD |
|
|
CA370722260 rs1411116945 |
266 | H>N | No |
ClinGen TOPMed |
|
| TCGA novel | 269 | S>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4717764 rs745859990 |
269 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs1347232480 CA370722292 |
270 | T>I | No |
ClinGen gnomAD |
|
|
CA4717765 rs777149932 |
272 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1431210478 CA370722312 |
273 | I>M | No |
ClinGen TOPMed |
|
|
COSM348136 rs529555864 CA4717767 COSM348137 |
273 | I>T | lung [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA4717766 rs562215790 |
273 | I>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA4717768 rs773622372 |
274 | V>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1031738432 CA175125602 |
274 | V>I | No |
ClinGen TOPMed |
|
|
rs188774054 CA4717769 |
275 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs769707508 CA4717770 |
275 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717773 rs764053490 |
281 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA370722357 rs1183313553 |
281 | E>A | No |
ClinGen gnomAD |
|
|
CA175125636 rs764053490 |
281 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1472419640 CA370722375 |
283 | Q>R | No |
ClinGen gnomAD |
|
|
CA370722378 rs1161610651 |
284 | L>M | No |
ClinGen gnomAD |
|
|
CA370722381 rs1563394196 |
284 | L>P | No |
ClinGen Ensembl |
|
| TCGA novel | 285 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370722399 rs1367133740 |
287 | E>V | No |
ClinGen TOPMed gnomAD |
|
|
CA370722406 rs1277985647 |
288 | H>R | No |
ClinGen TOPMed |
|
|
CA370722413 rs1425102174 |
289 | L>S | No |
ClinGen gnomAD |
|
|
CA4717775 rs144972979 |
290 | D>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs533338214 CA4717776 |
291 | R>H | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs1389953163 CA370722433 |
292 | P>L | No |
ClinGen gnomAD |
|
|
CA370722444 rs1228118410 |
294 | L>V | No |
ClinGen TOPMed |
|
|
rs1309218706 CA370722459 |
296 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA4717780 rs745727874 |
299 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1313589034 CA370722484 |
300 | L>P | No |
ClinGen gnomAD |
|
|
CA4717782 rs779590451 |
302 | E>G | No |
ClinGen ExAC |
|
|
CA4717784 rs768017536 |
304 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776164598 CA4717786 |
309 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA370722548 rs983548200 |
310 | N>I | No |
ClinGen gnomAD |
|
|
CA175125706 rs983548200 |
310 | N>S | No |
ClinGen gnomAD |
|
|
CA370722555 rs1386990673 |
311 | L>P | No |
ClinGen gnomAD |
|
|
rs200885810 CA4717788 |
313 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1371184301 CA370722565 |
313 | R>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1371184301 CA370722567 |
313 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs773497727 CA4717790 |
316 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1456445791 CA370722593 |
317 | L>P | No |
ClinGen TOPMed |
|
|
CA4717791 rs763240295 |
320 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774468254 CA4717793 |
323 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1281032601 CA370723237 |
329 | I>K | No |
ClinGen gnomAD |
|
|
rs750292042 CA4717821 |
330 | I>N | No |
ClinGen ExAC gnomAD |
|
|
CA4717820 rs750292042 |
330 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA4717822 rs145121919 |
331 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4717824 rs754583761 |
333 | E>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717826 rs780881691 |
334 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs780881691 CA4717825 |
334 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA370723300 rs1194773036 |
334 | G>R | No |
ClinGen TOPMed |
|
|
CA370723315 rs1267335480 |
335 | V>E | No |
ClinGen TOPMed |
|
| TCGA novel | 335 | V>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4717828 rs144610156 |
336 | T>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs749707283 CA4717829 |
337 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749707283 CA4717830 |
337 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746307854 CA4717833 |
338 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1252077231 CA370723395 |
342 | E>Q | No |
ClinGen gnomAD |
|
|
rs146651641 CA4717834 |
345 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs199861550 CA4717836 |
346 | A>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA370723421 rs1455867093 |
346 | A>P | No |
ClinGen gnomAD |
|
|
rs1455867093 CA370723422 |
346 | A>S | No |
ClinGen gnomAD |
|
|
rs1455867093 CA370723420 |
346 | A>T | No |
ClinGen gnomAD |
|
|
rs199861550 CA4717837 |
346 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs200034574 CA175126439 |
347 | C>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4717838 rs200034574 |
347 | C>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs200034574 CA370723427 |
347 | C>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs766408230 CA4717840 |
349 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs1281243677 CA370723439 |
349 | A>T | No |
ClinGen TOPMed |
|
|
rs774005560 CA4717841 |
350 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
TCGA novel rs1586017323 CA370723443 |
350 | R>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA Ensembl |
| TCGA novel | 351 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM1099613 COSM1099612 CA4717842 rs140730377 |
351 | G>R | endometrium [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA370723457 rs1216486401 |
352 | M>I | No |
ClinGen gnomAD |
|
|
rs752306519 CA4717844 |
352 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs1290691000 CA370723459 |
353 | R>G | No |
ClinGen gnomAD |
|
|
CA175126446 rs145867034 |
355 | L>P | No |
ClinGen ESP TOPMed |
|
|
CA370723476 rs755785230 |
356 | G>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717845 rs755785230 |
356 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1673863 rs200302486 COSM1673862 CA4717846 |
357 | L>F | prostate [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs757697771 CA4717848 |
358 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746192491 CA4717850 |
359 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA4717851 rs111985311 |
360 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA370723513 rs747174125 |
362 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1479455897 CA370723515 |
362 | L>P | No |
ClinGen TOPMed |
|
|
rs747174125 CA4717853 |
362 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs202148627 CA4717855 |
363 | R>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM1472116 COSM1472115 rs376204298 CA4717856 |
363 | R>Q | prostate [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
| TCGA novel | 364 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4717857 rs770752782 |
366 | L>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370723539 rs770752782 |
366 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 367 | T>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4717858 rs776017169 |
367 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA4717859 rs776017169 |
367 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370724002 rs1238349091 |
371 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
CA370723997 rs1185981926 |
371 | D>G | No |
ClinGen gnomAD |
|
|
CA370724026 rs767053584 |
373 | H>P | No |
ClinGen ExAC gnomAD |
|
|
rs767053584 CA4717888 |
373 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA370724041 rs1586024863 |
374 | L>P | No |
ClinGen Ensembl |
|
|
rs1421178220 CA370724056 |
375 | K>N | No |
ClinGen gnomAD |
|
|
rs755411571 CA4717890 |
376 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs1175086142 CA370724082 |
377 | N>S | No |
ClinGen gnomAD |
|
|
CA4717891 rs1554538746 |
378 | V>I | No |
ClinGen Ensembl |
|
|
rs1019742176 CA175127465 |
379 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA370724131 rs1325587180 |
381 | S>C | No |
ClinGen gnomAD |
|
|
CA175127467 rs964217639 |
382 | L>F | No |
ClinGen TOPMed |
|
|
rs1428355369 CA370724143 |
382 | L>P | No |
ClinGen gnomAD |
|
|
CA370724165 rs1283499072 |
384 | L>H | No |
ClinGen TOPMed |
|
|
CA4717893 rs781441934 |
384 | L>V | No |
ClinGen ExAC |
|
|
CA4717894 rs752915294 |
387 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs756304385 CA4717895 |
387 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs756304385 CA370724203 |
387 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717897 rs749436119 |
388 | T>N | No |
ClinGen ExAC |
|
|
rs1586025184 CA370724207 |
388 | T>P | No |
ClinGen Ensembl |
|
|
CA370724230 rs1206083644 |
389 | F>L | No |
ClinGen gnomAD |
|
|
CA4717898 rs771980736 |
389 | F>S | No |
ClinGen ExAC gnomAD |
|
|
CA370724239 rs1446983280 |
390 | Y>C | No |
ClinGen gnomAD |
|
|
rs780014217 CA4717900 |
390 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs780014217 CA4717899 |
390 | Y>N | No |
ClinGen ExAC gnomAD |
|
|
CA370724237 rs1446983280 |
390 | Y>S | No |
ClinGen gnomAD |
|
|
CA4717901 rs768454587 |
391 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs776307287 CA4717902 |
392 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717903 rs200474752 |
394 | V>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs893811139 CA175127483 |
395 | K>R | No |
ClinGen Ensembl |
|
|
CA370724401 rs1313584716 |
398 | P>L | No |
ClinGen TOPMed |
|
|
CA370724383 rs1342153474 |
398 | P>T | No |
ClinGen TOPMed |
|
|
CA370724425 rs1398129510 |
399 | I>T | No |
ClinGen gnomAD |
|
| rs763212040 | 400 | E>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370724470 rs1399530110 |
401 | I>L | No |
ClinGen TOPMed |
|
|
CA175127521 rs1042847605 |
401 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1358672277 CA370724475 |
401 | I>T | No |
ClinGen TOPMed |
|
|
CA370724484 rs752073783 |
402 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752073783 CA4717909 |
402 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 406 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370724552 rs1343668472 |
406 | E>V | No |
ClinGen gnomAD |
|
|
CA4717936 rs760991828 |
407 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA370725198 rs1435605763 |
407 | A>V | No |
ClinGen gnomAD |
|
|
rs764267866 CA4717937 |
408 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs753165229 CA175128803 |
409 | K>T | No |
ClinGen Ensembl |
|
|
rs958393935 CA175128820 |
411 | D>G | No |
ClinGen TOPMed |
|
|
rs754016101 CA4717938 |
413 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1023918565 CA175128838 |
414 | V>A | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA4717940 rs112380505 |
415 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1099614 COSM1099615 CA175128850 rs894523403 |
416 | L>* | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
CA4717942 rs754932891 |
417 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717943 rs781043985 |
418 | T>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 419 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4717945 rs755934759 |
419 | F>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA175128888 rs113805573 |
421 | E>G | No |
ClinGen Ensembl |
|
|
CA370725287 rs748892988 |
422 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717947 rs748892988 |
422 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs112258553 CA4717949 |
424 | E>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA370725305 rs1250439494 |
425 | N>D | No |
ClinGen TOPMed gnomAD |
|
|
CA4717952 rs374619049 |
428 | D>A | No |
ClinGen ESP ExAC gnomAD |
|
|
rs745425021 CA4717951 |
428 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA4717953 rs775899648 |
431 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA4717954 rs761273566 |
432 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370725389 rs762021381 |
437 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1221119013 CA370725423 |
440 | D>E | No |
ClinGen gnomAD |
|
|
CA4717977 rs770029509 |
440 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs773267715 CA4717978 |
442 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs763260402 CA4717979 |
443 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA370725439 rs763260402 |
443 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs766312848 CA4717980 |
444 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA370725458 rs1258665185 |
446 | P>S | No |
ClinGen gnomAD |
|
|
CA370725456 rs1258665185 |
446 | P>T | No |
ClinGen gnomAD |
|
|
rs751664700 CA4717983 |
448 | T>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 448 | T>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs764184697 CA370725494 |
452 | I>K | No |
ClinGen ExAC gnomAD |
|
|
rs764184697 CA4717985 |
452 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs147462562 CA4717984 |
452 | I>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1381986036 CA370725514 |
455 | S>L | No |
ClinGen TOPMed |
|
|
CA4717986 rs753662493 |
457 | P>A | No |
ClinGen ExAC gnomAD |
|
|
CA4717987 rs757157302 |
457 | P>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370725524 rs753662493 |
457 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs1159025513 CA370725548 |
458 | I>T | No |
ClinGen gnomAD |
|
|
CA4717989 rs749992245 |
460 | L>S | No |
ClinGen ExAC gnomAD |
|
|
CA4717990 rs370581255 |
461 | P>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA370725592 rs1458408313 |
461 | P>S | No |
ClinGen TOPMed |
|
|
rs779360886 CA4717991 |
463 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4717992 rs372995502 |
464 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1471580638 CA370725638 |
464 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1402781354 CA370725692 |
467 | S>F | No |
ClinGen gnomAD |
|
|
rs769134544 CA4717993 |
468 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA370725736 rs1367696079 |
470 | E>D | No |
ClinGen gnomAD |
|
|
CA4718023 rs771034690 |
473 | L>R | No |
ClinGen ExAC gnomAD |
|
|
CA4718024 rs774753456 |
474 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs1480461184 CA370726030 |
475 | A>G | No |
ClinGen TOPMed |
|
|
CA370726028 rs1480461184 |
475 | A>V | No |
ClinGen TOPMed |
|
|
rs1466020754 CA370726065 |
478 | Q>K | No |
ClinGen gnomAD |
|
|
rs150451779 CA4718026 |
480 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4718028 rs761586668 |
481 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4718030 rs772863192 |
482 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370726120 rs772863192 |
482 | Q>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1214214465 CA370726129 |
482 | Q>L | No |
ClinGen gnomAD |
|
|
rs1276312479 CA370726149 |
483 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
rs571396653 CA4718031 |
484 | S>C | No |
ClinGen 1000Genomes ExAC |
|
|
rs766196251 CA4718033 |
485 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
CA4718034 rs143818037 |
486 | A>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4718035 rs143818037 |
486 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1212681083 CA370726197 |
487 | S>G | No |
ClinGen gnomAD |
|
|
CA175132829 rs960061113 |
487 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
CA175132834 rs886093015 |
488 | S>L | No |
ClinGen Ensembl |
|
|
rs752273597 CA4718038 |
490 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA370726234 rs1191074213 |
490 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1586039246 CA370726250 |
491 | A>E | No |
ClinGen Ensembl |
|
|
rs756566429 CA4718039 |
491 | A>T | No |
ClinGen ExAC gnomAD |
No associated diseases with Q2VYF4
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ribosome binding | Binding to a ribosome. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular metal ion homeostasis | Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06493 | YLH47 | LETM1 domain-containing protein YLH47, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q0VCA3 | LETM1 | Mitochondrial proton/calcium exchanger protein | Bos taurus (Bovine) | PR |
| Q5ZK33 | LETM1 | Mitochondrial proton/calcium exchanger protein | Gallus gallus (Chicken) | PR |
| O95202 | LETM1 | Mitochondrial proton/calcium exchanger protein | Homo sapiens (Human) | PR |
| Q9Z2I0 | Letm1 | Mitochondrial proton/calcium exchanger protein | Mus musculus (Mouse) | PR |
| Q7TNU7 | Letm2 | LETM1 domain-containing protein LETM2, mitochondrial | Mus musculus (Mouse) | PR |
| Q5XIN6 | Letm1 | Mitochondrial proton/calcium exchanger protein | Rattus norvegicus (Rat) | PR |
| Q5PQQ5 | Letm2 | LETM1 domain-containing protein LETM2, mitochondrial | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFYSYNSVL | AIARTRFPSH | FVHPTCSSYS | PSCAFLHLPD | SHLNKTCMKN | YESKKYSDPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QPGNTVLHPG | TRLIQKLHTS | TCWLQEVPGK | PQLEQATKHP | QVTSPQATKE | TGMEIKEGKQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYRQKIMDEL | KYYYNGFYLL | WIDAKVAARM | VWRLLHGQVL | TRRERRRLLR | TCVDFFRLVP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FMVFLIVPFM | EFLLPVFLKL | FPEMLPSTFE | SESKKEEKQK | KKMAVKLELA | KFLQETMTEM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ARRNRAKMGD | ASTQLSSYVK | QVQTGHKPST | KEIVRFSKLF | EDQLALEHLD | RPQLVALCKL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LELQTFGTNN | LLRFQLLMKL | KSIKADDEII | AKEGVTALSV | SELQAACRAR | GMRSLGLTEE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QLRQQLTEWQ | DLHLKENVPP | SLLLLSRTFY | LIDVKPKPIE | IPLSGEAPKT | DILVELPTFT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ESKENMVDLA | PQLKGTKDED | FIQPPPVTSS | PITPSTPISL | PKGPITSSEE | PTLQAKSQMT |
| 490 | |||||
| AQNSKASSKG | A |