Q5PQQ5

PR
Gene name
Letm2
Protein name
LETM1 domain-containing protein LETM2, mitochondrial
Names
LETM1 and EF-hand domain-containing protein 2, Leucine zipper-EF-hand-containing transmembrane protein 1-like
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:361169
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

58-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5PQQ5

Entry ID Method Resolution Chain Position Source
AF-Q5PQQ5-F1 Predicted AlphaFoldDB

No variants for Q5PQQ5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5PQQ5

No associated diseases with Q5PQQ5

2 regional properties for Q5PQQ5

Type Name Position InterPro Accession
domain LETM1-like, ribosome-binding domain 159 - 440 IPR033122
domain LETM2, N-terminal 1 - 109 IPR045742

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

1 GO annotations of molecular function

Name Definition
ribosome binding Binding to a ribosome.

1 GO annotations of biological process

Name Definition
cellular metal ion homeostasis Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06493 YLH47 LETM1 domain-containing protein YLH47, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q0VCA3 LETM1 Mitochondrial proton/calcium exchanger protein Bos taurus (Bovine) PR
Q5ZK33 LETM1 Mitochondrial proton/calcium exchanger protein Gallus gallus (Chicken) PR
O95202 LETM1 Mitochondrial proton/calcium exchanger protein Homo sapiens (Human) PR
Q2VYF4 LETM2 LETM1 domain-containing protein LETM2, mitochondrial Homo sapiens (Human) PR
Q9Z2I0 Letm1 Mitochondrial proton/calcium exchanger protein Mus musculus (Mouse) PR
Q7TNU7 Letm2 LETM1 domain-containing protein LETM2, mitochondrial Mus musculus (Mouse) PR
Q5XIN6 Letm1 Mitochondrial proton/calcium exchanger protein Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAFYSYNSFL AIFWTRLPGH SVHPPCSHFP PLAFFHLPDS HLRTAYMKNC GSRKYSYPGL
70 80 90 100 110 120
TGNNKVHPLR TRLPQKLHTT CWLQNHPGKP QPEQIPEEPK ATDPQPTKDD QTEVAEGKWS
130 140 150 160 170 180
LRQKIIDEVK YYYNGFSLLW IDTKVAARIV WRLLHGQVLT RRERRRLLRT CADVFRLVPF
190 200 210 220 230 240
VVFIIVPFME FLIPVFLKLF PDMLPSTFES ESKKEEKQKK MMGAKLEIAK FLQETMTEMA
250 260 270 280 290 300
KRNRAKLDDD SSDSSQLSSY VKQVQTGHKP STKEIVRFSK LFEDQLALEH LRRPQLVALC
310 320 330 340 350 360
KLLELQAFGT NNLLRFQLLM TLRSIKADDE VIAKEGVKAL SVSELQAACR ARGMRSLGLT
370 380 390 400 410 420
EEQLRQQLTE WLDLHLKENV PPSLLLLSRT FYLIDVKPKP IELPPSIETP KTNLGIPSSP
430 440 450
PPESKEDITD PAPQLNGTKI LQAKSQETSQ NSKANSKGA