Q924L1
Gene name |
Letmd1 |
Protein name |
LETM1 domain-containing protein 1 |
Names |
Cervical cancer receptor, MCC-32 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68614 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q924L1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q924L1-F1 | Predicted | AlphaFoldDB |
12 variants for Q924L1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs232364311 | 17 | T>A | No | EVA | |
| rs3389388922 | 96 | L>* | No | EVA | |
| rs3389383590 | 118 | H>L | No | EVA | |
| rs3389370327 | 148 | P>R | No | EVA | |
| rs3389405356 | 174 | K>R | No | EVA | |
| rs3389396558 | 201 | A>D | No | EVA | |
| rs3389396561 | 221 | V>M | No | EVA | |
| rs3389388937 | 223 | S>N | No | EVA | |
| rs3389360425 | 229 | A>V | No | EVA | |
| rs3389383636 | 256 | A>D | No | EVA | |
| rs13460837 | 281 | T>S | No | EVA | |
| rs3389407791 | 357 | E>V | No | EVA |
No associated diseases with Q924L1
1 regional properties for Q924L1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | LETM1-like, ribosome-binding domain | 120 - 360 | IPR033122 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ribosome binding | Binding to a ribosome. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. |
| regulation of phagocytosis | Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06493 | YLH47 | LETM1 domain-containing protein YLH47, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A3KN46 | LETMD1 | LETM1 domain-containing protein 1 | Bos taurus (Bovine) | PR |
| Q7TNU7 | Letm2 | LETM1 domain-containing protein LETM2, mitochondrial | Mus musculus (Mouse) | PR |
| Q9Z2I0 | Letm1 | Mitochondrial proton/calcium exchanger protein | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALSRVCWAR | AALWGSTVAP | GPFVTRRLQL | GRSGPAWRAP | RSSKLHLSPK | ADVKNLISYV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VTKTRAINGS | YHRFLGRHFP | RFYALYTTFM | KGIQMLWADG | KKARRIKADM | WKQNLKFHQL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYREMEHLRQ | FRRDITKCLF | VGLISIPPFA | NYLVFLLMYL | FPRQLLVKHF | WTPKQQIDFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DVYHGLRRRS | HSEVITHLRR | ASTFVSHEKL | RRQLTDLCTK | VQSGTHPAAQ | DVLALRDCFS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TYPLGFSQLQ | ASQMRALSQA | MLLTPYLPPP | LLRQRLKSHT | TVIHQLDRAL | AKLGIGQLTA |
| 310 | 320 | 330 | 340 | 350 | |
| QEVKSACYLR | GLNSTHIADD | RCRAWLGEWL | HISCSLKEPE | LSLLLHNVVL | LSTNYLETRR |