A3KN46

PR
Gene name
LETMD1
Protein name
LETM1 domain-containing protein 1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:514595
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

148-240 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3KN46

Entry ID Method Resolution Chain Position Source
AF-A3KN46-F1 Predicted AlphaFoldDB

No variants for A3KN46

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3KN46

No associated diseases with A3KN46

1 regional properties for A3KN46

Type Name Position InterPro Accession
domain Luciferase-like domain 20 - 339 IPR011251

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass membrane protein
  • Nucleus
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.

1 GO annotations of molecular function

Name Definition
ribosome binding Binding to a ribosome.

1 GO annotations of biological process

Name Definition
mitochondrion organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06493 YLH47 LETM1 domain-containing protein YLH47, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q0VCA3 LETM1 Mitochondrial proton/calcium exchanger protein Bos taurus (Bovine) PR
Q924L1 Letmd1 LETM1 domain-containing protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MALSRVCWAR AALWGSAVPP GLYVVRRLQF VRSGLTWGAP RSSKLHLSPK ADVKSLISYV
70 80 90 100 110 120
VTKTKVINGK YHRFLGRHFP RFYVPYTIFM KGLQMLWADG KKARRIKTNM WKHNIKFHQL
130 140 150 160 170 180
PYREMEHLRQ FRRDVTKCLF LGILSIPPFA NYLVFLLMYL FPRQLLIRHF WTPKQQIDFL
190 200 210 220 230 240
DIYHALRKQS HPEILCYLEK VVPLISDAGL QWHMTELCTK MQRGTHPAVH DILALRECFA
250 260 270 280 290 300
NHPLGMDQLR ALQMKALCRA MLLTPYLPSV LLRHRLKTHT TVIHQLDKAL AKLGVGQLTA
310 320 330 340 350
QEVKSACYLR GLNSTHIAEE RCRTWLGEWL QISCSLKETE LSLLLHNVVL LSINYVGSRR