AiPD: Autoinhibited Protein Database

P08670

Gene name	VIM
Protein name	Vimentin
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7431
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

382-457 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

382-457 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

24 structures for P08670

Entry ID	Method	Resolution	Chain	Position	Source
1GK4	X-ray	230 A	A/B/C/D/E/F	328-411	PDB
1GK6	X-ray	190 A	A/B	385-412	PDB
1GK7	X-ray	140 A	A	102-138	PDB
3G1E	X-ray	183 A	A/B	102-138	PDB
3KLT	X-ray	270 A	A/B/C/D	263-334	PDB
3S4R	X-ray	245 A	A/B	99-189	PDB
3SSU	X-ray	260 A	A/B	99-189	PDB
3SWK	X-ray	170 A	A/B	153-238	PDB
3TRT	X-ray	230 A	A/B	261-335	PDB
3UF1	X-ray	281 A	A/B/C/D	144-251	PDB
4MCY	X-ray	230 A	C	66-78	PDB
4MCZ	X-ray	241 A	C	59-71	PDB
4MD0	X-ray	219 A	C	59-71	PDB
4MD5	X-ray	165 A	C	66-78	PDB
4MDI	X-ray	200 A	C	66-78	PDB
4MDJ	X-ray	170 A	C	66-78	PDB
4YPC	X-ray	144 A	A	161-243	PDB
4YV3	X-ray	200 A	A/B/C	161-238	PDB
5WHF	X-ray	225 A	A/B/C/D/E/F/G/H	153-238	PDB
6ATF	X-ray	190 A	C/F	59-71	PDB
6ATI	X-ray	198 A	C/F	59-71	PDB
6BIR	X-ray	230 A	C	419-431	PDB
6YXK	X-ray	200 A	C	59-74	PDB
AF-P08670-F1	Predicted				AlphaFoldDB

407 variants for P08670

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000203397 rs864309690 RCV000488584	6	V>missing	Cataract 30 Developmental cataract [ClinVar]	Yes	ClinVar dbSNP
CA5426364 RCV000651306 rs773938980	56	S>Y	Cataract 30 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA214748 rs121917775 RCV000056967 RCV000012983 VAR_070100	151	E>K	Cataract 30 CTRCT30; the mutation increases the proteasome activity in transfected cells; causes also a severe kinetic defect in vimentin assembly both in vitro and in vivo [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt TOPMed dbSNP gnomAD
RCV001220959 rs1846752790	156	E>D	Cataract 30 [ClinVar]	Yes	ClinVar dbSNP
RCV000952394 rs149942621 CA5426418	181	D>A	Cataract 30 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA16622109 VAR_078860 RCV000488719 rs1085307141	208	Q>R	Cataract 30 CTRCT30; unknown pathological significance [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt dbSNP gnomAD
RCV002547220 rs145152785 CA5426556	250	Q>R	Cataract 30 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5426558 rs773762488 RCV001232814	253	H>R	Cataract 30 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001195968 CA5426688 rs749084801	381	R>C	Cataract 30 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1846907790 RCV001236540	459	S>missing	Cataract 30 [ClinVar]	Yes	ClinVar dbSNP
CA5426330 rs756656437	2	S>P		No	ClinGen ExAC
rs1436554874 CA376174573	4	R>G		No	ClinGen gnomAD
TCGA novel	5	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376174615 rs1230052576	6	V>A		No	ClinGen gnomAD
CA5426333 rs755242950	6	V>M		No	ClinGen ExAC gnomAD
rs779204525 RCV000994358 CA376174641	8	S>L		No	ClinGen ClinVar ExAC dbSNP gnomAD
CA376174631 rs1288770216	8	S>T		No	ClinGen gnomAD
CA5426334 rs779204525	8	S>W		No	ClinGen ExAC gnomAD
rs1452327776 CA376174680	11	Y>C		No	ClinGen gnomAD
CA376174689 rs1220895620	12	R>C		No	ClinGen gnomAD
rs1245254535 CA376174697	12	R>P		No	ClinGen gnomAD
rs1220895620 CA376174688	12	R>S		No	ClinGen gnomAD
rs1031859925 CA203595558	13	R>S		No	ClinGen Ensembl
CA376174726 rs1278642875	14	M>T		No	ClinGen gnomAD
TCGA novel	15	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773471865 CA5426338	16	G>R		No	ClinGen ExAC gnomAD
CA5426339 rs747053288	17	G>C		No	ClinGen ExAC gnomAD
rs11545549 CA203595583	18	P>L		No	ClinGen gnomAD
rs771023210 CA5426340	19	G>S		No	ClinGen ExAC gnomAD
rs776383614 CA5426341	21	A>E		No	ClinGen ExAC gnomAD
CA5426342 rs776383614	21	A>V		No	ClinGen ExAC gnomAD
rs1202092452 CA376174847	22	S>R		No	ClinGen gnomAD
rs527439944 CA203595610	23	R>Q		No	ClinGen Ensembl
rs910563895 CA203595603	23	R>W		No	ClinGen TOPMed
rs957631225 CA203595614	25	S>R		No	ClinGen Ensembl
rs775343323 CA376174900	27	S>G		No	ClinGen ExAC TOPMed gnomAD
CA376174904 rs1356941925	27	S>N		No	ClinGen gnomAD
rs775343323 CA5426344	27	S>R		No	ClinGen ExAC TOPMed gnomAD
CA376174906 rs1356941925	27	S>T		No	ClinGen gnomAD
rs1194887764 CA376174916	28	R>W		No	ClinGen TOPMed
CA5426345 rs762644216	31	V>L		No	ClinGen ExAC TOPMed gnomAD
rs763707422 CA5426346	33	T>A		No	ClinGen ExAC gnomAD
rs1344328729 CA376174988	33	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5426348 rs756711607	35	T>A		No	ClinGen ExAC TOPMed gnomAD
rs766889315 CA5426349	36	R>C		No	ClinGen ExAC TOPMed gnomAD
rs754236131 CA376175027	36	R>H		No	ClinGen ExAC gnomAD
rs754236131 CA5426350	36	R>P		No	ClinGen ExAC gnomAD
CA5426351 rs755500924	41	G>S		No	ClinGen ExAC gnomAD
rs1382854843 CA376175124	42	S>R		No	ClinGen gnomAD
rs748519640 CA5426353	43	A>T		No	ClinGen ExAC gnomAD
rs758730926 CA5426354	43	A>V		No	ClinGen ExAC gnomAD
CA376175145 rs1318337726	44	L>P		No	ClinGen TOPMed
rs778098458 CA5426356	45	R>H		No	ClinGen ExAC gnomAD
rs778098458 CA5426355	45	R>P		No	ClinGen ExAC gnomAD
rs1335964173 CA376175186	47	S>N		No	ClinGen gnomAD
CA5426359 rs745851443	48	T>I		No	ClinGen ExAC
CA5426358 rs201189169	48	T>P		No	ClinGen ExAC gnomAD
rs769749512 CA5426360	49	S>G		No	ClinGen ExAC gnomAD
rs1312761190 CA376175216	49	S>N		No	ClinGen gnomAD
CA376175217 rs1367516245	49	S>R		No	ClinGen gnomAD
TCGA novel	50	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs11545553 CA203595678 COSM3790665	50	R>H	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs775190116 CA5426361	51	S>I		No	ClinGen ExAC gnomAD
rs1588731496 CA376175251	52	L>I		No	ClinGen Ensembl
rs1294995968 CA376175281	54	A>P		No	ClinGen TOPMed
CA376175291 rs1337671316	54	A>V		No	ClinGen TOPMed gnomAD
CA5426362 rs762699034	55	S>*		No	ClinGen ExAC gnomAD
CA5426363 rs768322635	56	S>A		No	ClinGen ExAC gnomAD
rs749931833 CA5426367	57	P>L		No	ClinGen ExAC TOPMed gnomAD
rs767007282 CA5426366	57	P>S		No	ClinGen ExAC gnomAD
rs1215537817 CA376175334	58	G>S		No	ClinGen Ensembl
CA376175344 rs1564372278	58	G>V		No	ClinGen Ensembl
CA376175360 rs1253533842	60	V>M		No	ClinGen Ensembl
CA5426369 rs765742006	61	Y>C		No	ClinGen ExAC gnomAD
rs1474263020 CA376175419	64	R>H		No	ClinGen TOPMed
rs1402661582 CA376175440	65	S>F		No	ClinGen gnomAD
CA376175461 rs1445952624	67	A>D		No	ClinGen TOPMed
rs369470034 CA5426371	67	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5426372 rs778153530	68	V>M		No	ClinGen ExAC TOPMed gnomAD
rs928603903 CA203595706	69	R>H		No	ClinGen TOPMed gnomAD
CA376175490 rs928603903	69	R>L		No	ClinGen TOPMed gnomAD
CA376175492 rs928603903	69	R>P		No	ClinGen TOPMed gnomAD
CA376175482 rs1435968814	69	R>S		No	ClinGen gnomAD
CA203595711 rs777756098	71	R>Q		No	ClinGen TOPMed gnomAD
CA376175505 rs1235698818	71	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1202137863 CA376175525	72	S>N		No	ClinGen gnomAD
rs1270633135 CA376175550	74	V>M		No	ClinGen gnomAD
CA376175571 rs1402686254	75	P>L		No	ClinGen TOPMed gnomAD
rs757539736 CA5426375	75	P>S		No	ClinGen ExAC gnomAD
CA5426376 rs781179445	76	G>E		No	ClinGen ExAC gnomAD
rs972743635 CA203595723	76	G>R		No	ClinGen gnomAD
rs11545548 CA203595757	77	V>A		No	ClinGen ExAC gnomAD
CA5426378 rs11545548	77	V>G		No	ClinGen ExAC gnomAD
rs184701100 CA376175588	77	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5426377 rs184701100	77	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA376175602 rs1325594598	78	R>Q		No	ClinGen gnomAD
rs865981174 CA203595765	78	R>W		No	ClinGen gnomAD
rs867740022 CA203595767	81	Q>*		No	ClinGen Ensembl
CA376175651 rs1413835853	82	D>N		No	ClinGen gnomAD
CA203595769 rs1050023359	84	V>L		No	ClinGen gnomAD
CA376175707 rs1385094399	85	D>E		No	ClinGen TOPMed
CA5426380 rs749097460	85	D>N		No	ClinGen ExAC gnomAD
rs1324531976 CA376175712	86	F>L		No	ClinGen gnomAD
rs1221861802 CA376175750	88	L>P		No	ClinGen gnomAD
rs1330720517 CA376175740	88	L>V		No	ClinGen gnomAD
rs1290632621 CA376175762	89	A>V		No	ClinGen gnomAD
CA376175788 rs1228337366	91	A>T		No	ClinGen gnomAD
CA376175821 rs1259476721	93	N>T		No	ClinGen gnomAD
rs1452623960 CA376175833	94	T>A		No	ClinGen TOPMed
CA203595779 rs868327359	95	E>*		No	ClinGen Ensembl
CA376175849 rs1267669767	95	E>A		No	ClinGen gnomAD
CA5426382 rs774132663	96	F>L		No	ClinGen ExAC TOPMed gnomAD
CA376175897 rs529112487	98	N>D		No	ClinGen 1000Genomes gnomAD
CA376175903 rs1253712799	98	N>S		No	ClinGen gnomAD
rs529112487 CA203595786	98	N>Y		No	ClinGen 1000Genomes gnomAD
CA376176010 rs1361987967	106	E>*		No	ClinGen gnomAD
CA376176014 rs1459555504	106	E>V		No	ClinGen gnomAD
CA203595787 rs867113544	107	L>M		No	ClinGen Ensembl
CA376176024 rs1390058731	108	Q>*		No	ClinGen gnomAD
CA376176026 rs1403341247	108	Q>R		No	ClinGen gnomAD
rs534064028 CA376176056	112	D>E		No	ClinGen gnomAD
CA5426384 rs546992824	112	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA376176052 rs546992824	112	D>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA376176060 rs1305547785	113	R>C		No	ClinGen gnomAD
rs1246101455 CA376176066	114	F>L		No	ClinGen gnomAD
rs943771920 CA203595793	116	N>K		No	ClinGen Ensembl
rs772634201 CA5426385	117	Y>H		No	ClinGen ExAC gnomAD
rs1425939424 CA376176147	125	E>D		No	ClinGen TOPMed
CA203595794 rs565243670	126	Q>R		No	ClinGen Ensembl
TCGA novel	127	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376176155 rs1483298145	127	Q>K		No	ClinGen gnomAD
CA5426386 rs760190137	127	Q>R		No	ClinGen ExAC gnomAD
CA376176182 rs902288870	130	I>N		No	ClinGen TOPMed gnomAD
CA203595798 rs902288870	130	I>T		No	ClinGen TOPMed gnomAD
CA203595814 rs1053391219	131	L>P		No	ClinGen Ensembl
rs1216233618 CA376176188	132	L>M		No	ClinGen gnomAD
CA376176205 rs1045526760	134	E>D		No	ClinGen TOPMed gnomAD
rs532905834 CA5426391	135	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1437046531 CA376176232	138	L>P		No	ClinGen TOPMed
rs1296829264 CA376176256	142	G>S		No	ClinGen TOPMed gnomAD
CA5426392 rs757461918	144	S>W		No	ClinGen ExAC TOPMed gnomAD
CA5426393 rs781436766	145	R>C		No	ClinGen ExAC gnomAD
TCGA novel	146	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1243129674 CA376176296	148	D>E		No	ClinGen TOPMed gnomAD
rs750493891 CA5426394	148	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1245849739 CA376176299	149	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1281806487 CA376176317	151	E>D		No	ClinGen TOPMed
rs141319821 CA5426395	152	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA203595843 rs999034093	153	E>A		No	ClinGen TOPMed
rs779864520 CA5426396	154	M>I		No	ClinGen ExAC gnomAD
CA376176337 rs1323790047	154	M>T		No	ClinGen TOPMed
rs778724394 CA5426399	155	R>Q		No	ClinGen ExAC gnomAD
CA5426397 rs749293841	155	R>W		No	ClinGen ExAC gnomAD
CA5426400 rs747904058	156	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA376176352 rs1406458665	157	L>V		No	ClinGen TOPMed
rs1457202484 CA376176358	158	R>C		No	ClinGen Ensembl
CA376176359 rs1442903146	158	R>H		No	ClinGen gnomAD
rs771651752 CA5426401	159	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5426403 rs746513281	161	V>G		No	ClinGen ExAC gnomAD
rs772870142 CA5426402	161	V>M		No	ClinGen ExAC gnomAD
rs201551781 CA5426405	163	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs377524590 CA5426406	164	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5426407 rs569704234	165	T>S		No	ClinGen 1000Genomes ExAC gnomAD
rs774888281 CA5426408	166	N>K		No	ClinGen ExAC gnomAD
CA5426409 rs762190767	167	D>G		No	ClinGen ExAC
CA376176409 rs267602430	167	D>H		No	ClinGen Ensembl
rs267602430 CA203595863	167	D>N		No	ClinGen Ensembl
CA5426410 rs767649276	169	A>G		No	ClinGen ExAC gnomAD
TCGA novel	170	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1361960709 CA376176428	170	R>S		No	ClinGen gnomAD
rs11545550 CA203595882	172	E>Q		No	ClinGen Ensembl
CA5426413 rs766499205	173	V>A		No	ClinGen ExAC TOPMed gnomAD
CA5426412 rs756282194	173	V>M		No	ClinGen ExAC TOPMed gnomAD
CA203595888 rs746924511	174	E>D		No	ClinGen TOPMed gnomAD
TCGA novel	175	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	175	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1313812412 CA376176458	175	R>S		No	ClinGen gnomAD
rs1459941371 CA376176479	177	N>K		No	ClinGen gnomAD
rs1262487660 CA376176478	177	N>S		No	ClinGen gnomAD
rs1200409133 CA376176486	179	A>T		No	ClinGen TOPMed
rs866834871 CA203595901	180	E>K		No	ClinGen TOPMed gnomAD
rs1035750972 CA203595913	182	I>S		No	ClinGen Ensembl
CA376176507 rs1434157425	182	I>V		No	ClinGen gnomAD
CA376176516 rs1427593011	183	M>K		No	ClinGen TOPMed gnomAD
rs972689698 CA203595932	183	M>L		No	ClinGen gnomAD
CA376176513 rs972689698	183	M>V		No	ClinGen gnomAD
rs1459289381 CA376176522	184	R>C		No	ClinGen TOPMed gnomAD
CA376176523 rs1321743889	184	R>H		No	ClinGen gnomAD
CA376176520 rs1459289381	184	R>S		No	ClinGen TOPMed gnomAD
rs11545551 CA203595935	185	L>P		No	ClinGen Ensembl
rs201325757 CA5426419	185	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA376176532 rs1588732106	186	R>Q		No	ClinGen Ensembl
rs777297315 COSM1560852 CA5426420	187	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1343201036 CA376176546	188	K>R		No	ClinGen TOPMed
CA5426474 rs373295180	191	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA376177044 rs1334832994	192	E>V		No	ClinGen gnomAD
rs767474660 CA5426475	193	M>I		No	ClinGen ExAC gnomAD
rs1007423361 CA203596469	193	M>L		No	ClinGen Ensembl
rs1005304137 CA203596474	193	M>T		No	ClinGen TOPMed
rs1228442247 CA376177077	194	L>R		No	ClinGen gnomAD
CA376177083 rs1303380482	195	Q>*		No	ClinGen TOPMed
rs1406182336 CA376177121	198	E>K		No	ClinGen TOPMed
CA376177134 rs1363228886	199	A>T		No	ClinGen TOPMed
CA5426476 rs145760831	200	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1037734535 CA203596490	200	E>Q		No	ClinGen TOPMed gnomAD
CA376177167 rs765911800	201	N>I		No	ClinGen ExAC gnomAD
CA5426478 rs765911800	201	N>S		No	ClinGen ExAC gnomAD
CA376177165 rs1461281372	201	N>Y		No	ClinGen gnomAD
rs866251474 CA203596498	202	T>I		No	ClinGen Ensembl
CA376177188 rs1386842396	203	L>V		No	ClinGen TOPMed
CA376177211 rs143636314	204	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA376178189 rs1448514100	209	D>N		No	ClinGen TOPMed gnomAD
rs1455890040 CA376178217	211	D>N		No	ClinGen TOPMed
CA5426516 rs760525619	212	N>D		No	ClinGen ExAC gnomAD
CA5426517 rs116800063	212	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5426518 rs776474793	213	A>V		No	ClinGen ExAC gnomAD
rs138235394 CA5426520	216	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs752236825 COSM916835 CA5426521	217	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs762391438 CA5426522	217	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA376178296 rs752236825	217	R>S		No	ClinGen ExAC TOPMed gnomAD
CA376178318 rs1349809735	219	D>H		No	ClinGen TOPMed
rs1304135302 CA376178365	222	R>C		No	ClinGen TOPMed
CA5426524 rs750994048	222	R>H		No	ClinGen ExAC gnomAD
CA203597800 rs897144372	225	E>K		No	ClinGen TOPMed gnomAD
CA376178443 rs1301514675	226	S>C		No	ClinGen TOPMed
CA376178457 rs1305482290	227	L>F		No	ClinGen TOPMed gnomAD
CA5426525 rs756629184	228	Q>R		No	ClinGen ExAC gnomAD
CA5426526 rs780328725	229	E>D		No	ClinGen ExAC gnomAD
CA5426527 rs754196814	230	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1358309285 CA376178510	231	I>T		No	ClinGen gnomAD
CA5426528 rs755181628	237	L>P		No	ClinGen ExAC gnomAD
CA376178637 rs1248288717	239	E>D		No	ClinGen gnomAD
COSM538117 CA5426530 rs748255267	239	E>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA376178644 rs1399047851	240	E>*		No	ClinGen TOPMed
rs550798765 CA5426531	240	E>V		No	ClinGen 1000Genomes ExAC gnomAD
CA203597865 rs992484456	243	Q>R		No	ClinGen TOPMed
TCGA novel	247	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1445166789 CA376178839	249	I>F		No	ClinGen gnomAD
rs1290316532 CA376178853	250	Q>E		No	ClinGen gnomAD
rs776147609 CA5426557	252	Q>R		No	ClinGen ExAC gnomAD
rs761334638 CA5426560	253	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA5426562 rs139037306	256	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5426564 rs753092108 COSM916836	257	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5426565 rs758735029	258	V>M		No	ClinGen ExAC gnomAD
rs985623715 CA203597884	260	V>I		No	ClinGen TOPMed gnomAD
rs1257540470 CA376179020	261	S>A		No	ClinGen TOPMed
CA376179032 rs1480960201	261	S>F		No	ClinGen gnomAD
CA203597885 rs113576905	266	T>A		No	ClinGen TOPMed
CA376179104 rs150878383	266	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
COSM916837 CA5426567 rs150878383	266	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA376179101 rs113576905	266	T>S		No	ClinGen TOPMed
CA376179123 rs1402903305	267	A>V		No	ClinGen gnomAD
rs781127817 CA5426569	269	L>P		No	ClinGen ExAC gnomAD
rs1452626097 CA376179158	270	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs199515026 CA5426573	272	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA376179198 rs1175193193	273	R>C		No	ClinGen Ensembl
CA5426574 rs371176373	273	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	273	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376179264 rs1232637574	277	E>G		No	ClinGen TOPMed gnomAD
CA5426576 rs747619298	277	E>K		No	ClinGen ExAC gnomAD
rs1048526047 CA203597914	278	S>N		No	ClinGen TOPMed gnomAD
CA376179294 rs1285046692	279	V>A		No	ClinGen gnomAD
rs1356703491 CA376179291	279	V>L		No	ClinGen TOPMed
rs147133187 CA5426577	280	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs772585290 CA5426578	281	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	288	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776031097 CA5426581	288	E>K		No	ClinGen ExAC gnomAD
rs1471445445 CA376179432	289	E>*		No	ClinGen gnomAD
rs763360647 CA5426582	291	Y>H		No	ClinGen ExAC
rs764236805 CA5426583	293	S>Y		No	ClinGen ExAC
CA5426606 rs747735685	295	F>S	Variant assessed as Somatic; 9.301e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA376179827 rs578255169	296	A>S		No	ClinGen gnomAD
CA203598408 rs578255169	296	A>T		No	ClinGen gnomAD
TCGA novel	297	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376179856 rs1327165886	300	E>D		No	ClinGen TOPMed
rs144238562 CA5426607	300	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs754861364 CA5426608	301	A>S		No	ClinGen ExAC gnomAD
TCGA novel	301	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5426609 rs778821394	302	A>S		No	ClinGen ExAC gnomAD
rs752407631 CA5426610	303	N>S		No	ClinGen ExAC TOPMed gnomAD
rs752407631 CA376179872	303	N>T		No	ClinGen ExAC TOPMed gnomAD
rs552165238 CA5426612	304	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758102529 CA5426611	304	R>W		No	ClinGen ExAC TOPMed gnomAD
CA5426613 rs746534016	306	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1393644707 CA376179897	307	D>G		No	ClinGen gnomAD
rs11545546 CA203598446	308	A>S		No	ClinGen gnomAD
CA376179902 rs11545546	308	A>T		No	ClinGen gnomAD
CA376179907 rs1328451159	309	L>V		No	ClinGen gnomAD
rs780835078 CA5426615	310	R>H		No	ClinGen ExAC gnomAD
CA5426616 rs749857760	311	Q>R		No	ClinGen ExAC gnomAD
rs1316382347 CA376179933	313	K>R		No	ClinGen gnomAD
TCGA novel	314	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5426617 rs769012996	315	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1588735455 CA376179961	317	T>N		No	ClinGen Ensembl
rs1264296526 CA376179967	318	E>A		No	ClinGen gnomAD
CA5426618 COSM1321432 rs371431143	320	R>Q	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD
CA376180005 rs1171701809	324	Q>E		No	ClinGen TOPMed
rs772347590 CA5426620	324	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs779403092 CA203598462	324	Q>R		No	ClinGen Ensembl
CA5426621 rs773352810	325	S>C		No	ClinGen ExAC gnomAD
rs1374235575 CA376180026	327	T>S		No	ClinGen TOPMed
rs760880333 CA5426622	328	C>Y		No	ClinGen ExAC gnomAD
rs1588735491 CA376180053	331	D>V		No	ClinGen Ensembl
rs200772352 CA203598493	332	A>T		No	ClinGen ESP TOPMed gnomAD
rs753894774 CA5426624	333	L>F		No	ClinGen ExAC gnomAD
rs924667179 CA203598498	335	G>E		No	ClinGen Ensembl
rs111932484	336	T>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA5426656 rs778153870	337	N>S		No	ClinGen ExAC TOPMed gnomAD
rs369763215 CA203598664	337	N>Y		No	ClinGen Ensembl
CA5426657 rs747338188	341	E>K		No	ClinGen ExAC gnomAD
CA5426658 rs771168882	342	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5426659 rs376802470	342	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5426661 rs769833820	344	M>I		No	ClinGen ExAC gnomAD
COSM258350 CA5426662 rs775627643	345	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA376180388 rs775627643	345	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5426663 rs116370722	345	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
TCGA novel	346	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1049424533 CA203598685	347	M>I		No	ClinGen TOPMed
CA5426665 rs200740172	351	F>V		No	ClinGen ExAC TOPMed gnomAD
rs866598895 CA203598702	352	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs767278443 CA5426667	353	V>I		No	ClinGen ExAC gnomAD
CA203598716 rs766141377	354	E>A		No	ClinGen gnomAD
rs766141377 CA376180536	354	E>G		No	ClinGen gnomAD
rs750107979 CA5426668	355	A>V		No	ClinGen ExAC gnomAD
CA376180609 rs1197860827	359	Q>K		No	ClinGen gnomAD
CA376180613 rs1261710176	359	Q>R		No	ClinGen TOPMed
rs139818786 CA5426669	360	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA5426670 rs765859276	361	T>A		No	ClinGen ExAC gnomAD
rs114322672 CA5426671	362	I>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs114322672 CA5426672	362	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5426673 rs778207118	363	G>D		No	ClinGen ExAC gnomAD
rs751935909 CA5426674	364	R>C		No	ClinGen ExAC TOPMed gnomAD
CA203598729 rs371054027	364	R>H		No	ClinGen ESP
CA5426676 rs781618375	368	E>D		No	ClinGen ExAC TOPMed gnomAD
rs746135750 CA5426677	372	M>R		No	ClinGen ExAC TOPMed gnomAD
rs746135750 CA376180802	372	M>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	372	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5426678 rs770025384	373	K>R		No	ClinGen ExAC TOPMed gnomAD
rs768727457 CA5426681	375	E>K		No	ClinGen ExAC gnomAD
rs761834421 CA5426685	378	R>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	378	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5426683 rs201530534	378	R>C		No	ClinGen 1000Genomes ExAC TOPMed
rs761834421 CA5426684	378	R>P		No	ClinGen ExAC TOPMed gnomAD
rs760289106 CA5426687	379	H>P		No	ClinGen ExAC gnomAD
CA376180920 rs1358822322	380	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA376180929 rs1218008674	380	L>P		No	ClinGen gnomAD
CA5426689 rs35157876	381	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA376180943 rs35157876	381	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA376180967 rs1188442437	383	Y>H		No	ClinGen gnomAD
rs1267792443 CA376180983	384	Q>*		No	ClinGen gnomAD
CA5426692 rs752126893	386	L>V		No	ClinGen ExAC gnomAD
CA376181038 rs1588736025 RCV000853405	387	L>P		No	ClinGen ClinVar Ensembl dbSNP
CA376181091 rs1432057333	391	M>V		No	ClinGen gnomAD
CA376181141 rs1258626020	394	D>V		No	ClinGen TOPMed
CA376181162 rs1176198427	395	I>M		No	ClinGen gnomAD
CA376181156 rs1470562734	395	I>T		No	ClinGen gnomAD
rs1357615634 CA376181193	397	I>T		No	ClinGen gnomAD
TCGA novel	406	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	407	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1564374858 RCV000732045 CA376181342	408	E>K		No	ClinGen ClinVar Ensembl dbSNP
rs750758121 CA5426695	409	S>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	410	R>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5426714 rs373859810	410	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs750766626 CA5426715	412	S>Y		No	ClinGen ExAC gnomAD
rs756434736 CA5426716	415	L>F		No	ClinGen ExAC gnomAD
rs1564374995 CA376181531	416	P>A		No	ClinGen Ensembl
CA203599064 rs11545541	416	P>Q		No	ClinGen Ensembl
rs1276819494 CA376181544	417	N>D		No	ClinGen TOPMed
rs1490612095 CA376181595	420	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1038093456 CA203599085	421	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5426718 rs754167157	422	N>S		No	ClinGen ExAC TOPMed gnomAD
rs760767925 CA203599100	423	L>M		No	ClinGen Ensembl
CA203599390 rs955350530	430	S>A		No	ClinGen TOPMed
CA376181844 rs982699474	431	L>I		No	ClinGen TOPMed
CA203599392 rs982699474	431	L>V		No	ClinGen TOPMed
CA376181855 rs768266467	433	L>V		No	ClinGen ExAC gnomAD
CA376181860 rs146586974	434	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA5426750 rs146586974	434	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA376181874 rs1467601802	436	T>A		No	ClinGen TOPMed
CA376181888 rs1442649286	438	S>P		No	ClinGen gnomAD
rs1371902872 CA376181894	439	K>E		No	ClinGen TOPMed
CA5426752 rs372394023	439	K>R		No	ClinGen ESP ExAC gnomAD
rs777161019 CA5426753	442	L>P		No	ClinGen ExAC gnomAD
CA376181919 rs1424831707	443	L>V		No	ClinGen TOPMed
CA5426756 rs753033876	444	I>M		No	ClinGen ExAC gnomAD
CA5426755 rs765564921	444	I>N		No	ClinGen ExAC gnomAD
CA5426757 rs763073277	446	T>M		No	ClinGen ExAC gnomAD
rs1460602699 CA376181975	451	D>E		No	ClinGen TOPMed
CA5426760 rs757220075	452	G>E		No	ClinGen ExAC gnomAD
rs1414174359 CA376181982	453	Q>*		No	ClinGen gnomAD
rs1414174359 CA376181983	453	Q>E		No	ClinGen gnomAD
rs1214438836 CA376182003	454	V>I		No	ClinGen TOPMed
CA5426787 rs779935723	456	N>D		No	ClinGen ExAC TOPMed gnomAD
rs754678758 CA5426789	457	E>G		No	ClinGen ExAC TOPMed gnomAD
CA203599907 rs376668602	457	E>K		No	ClinGen ESP gnomAD
CA5426791 rs747701399	458	T>A		No	ClinGen ExAC TOPMed gnomAD
CA376182030 rs771777895	458	T>I		No	ClinGen ExAC gnomAD
CA5426792 rs771777895	458	T>N		No	ClinGen ExAC gnomAD
TCGA novel	460	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	460	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5426793 rs777412987	461	H>P		No	ClinGen ExAC gnomAD
CA376182053 rs1158260463	462	H>D		No	ClinGen gnomAD
rs11545543 CA203599925	462	H>P		No	ClinGen Ensembl
rs775956508 CA5426796	463	D>G		No	ClinGen ExAC gnomAD
CA5426795 rs372258946	463	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs781197884 CA203599960	464	D>E		No	ClinGen TOPMed gnomAD
CA5426797 rs763181437	464	D>H		No	ClinGen ExAC gnomAD

No associated diseases with P08670

1 regional properties for P08670

Type	Name	Position	InterPro Accession
domain	AP2/ERF domain	53 - 117	IPR001471

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cytoplasm, cytoskeleton Nucleus matrix Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

16 GO annotations of cellular component

Name	Definition
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cell leading edge	The area of a motile cell closest to the direction of movement.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
intermediate filament	A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.
intermediate filament cytoskeleton	Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
microtubule organizing center	An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.
peroxisome	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
phagocytic vesicle	A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
polysome	A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

8 GO annotations of molecular function

Name	Definition
double-stranded RNA binding	Binding to double-stranded RNA.
identical protein binding	Binding to an identical protein or proteins.
keratin filament binding	Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells.
molecular adaptor activity	The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
protein domain specific binding	Binding to a specific domain of a protein.
scaffold protein binding	Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
structural constituent of cytoskeleton	The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
structural constituent of eye lens	The action of a molecule that contributes to the structural integrity of the lens of an eye.

13 GO annotations of biological process

Name	Definition
astrocyte development	The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
Bergmann glial cell differentiation	The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate.
cellular response to interferon-gamma	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
cellular response to lipopolysaccharide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to muramyl dipeptide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
intermediate filament organization	Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
lens fiber cell development	The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
negative regulation of neuron projection development	Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
neuron projection development	The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of collagen biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
positive regulation of translation	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
regulation of mRNA stability	Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
SMAD protein signal transduction	The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P02545	LMNA	Prelamin-A/C	Homo sapiens (Human)	PR
P17661	DES	Desmin	Homo sapiens (Human)	PR
P41219	PRPH	Peripherin	Homo sapiens (Human)	PR
P14136	GFAP	Glial fibrillary acidic protein	Homo sapiens (Human)	PR
P14733	Lmnb1	Lamin-B1	Mus musculus (Mouse)	PR
P48678	Lmna	Prelamin-A/C	Mus musculus (Mouse)	PR
P21619	Lmnb2	Lamin-B2	Mus musculus (Mouse)	PR
P31001	Des	Desmin	Mus musculus (Mouse)	PR
P20152	Vim	Vimentin	Mus musculus (Mouse)	PR
P03995	Gfap	Glial fibrillary acidic protein	Mus musculus (Mouse)	PR
P70615	Lmnb1	Lamin-B1	Rattus norvegicus (Rat)	PR
P48679	Lmna	Prelamin-A/C	Rattus norvegicus (Rat)	PR
Q21065	ifa-3	Intermediate filament protein ifa-3	Caenorhabditis elegans	PR

10	20	30	40	50	60
MSTRSVSSSS	YRRMFGGPGT	ASRPSSSRSY	VTTSTRTYSL	GSALRPSTSR	SLYASSPGGV
70	80	90	100	110	120
YATRSSAVRL	RSSVPGVRLL	QDSVDFSLAD	AINTEFKNTR	TNEKVELQEL	NDRFANYIDK
130	140	150	160	170	180
VRFLEQQNKI	LLAELEQLKG	QGKSRLGDLY	EEEMRELRRQ	VDQLTNDKAR	VEVERDNLAE
190	200	210	220	230	240
DIMRLREKLQ	EEMLQREEAE	NTLQSFRQDV	DNASLARLDL	ERKVESLQEE	IAFLKKLHEE
250	260	270	280	290	300
EIQELQAQIQ	EQHVQIDVDV	SKPDLTAALR	DVRQQYESVA	AKNLQEAEEW	YKSKFADLSE
310	320	330	340	350	360
AANRNNDALR	QAKQESTEYR	RQVQSLTCEV	DALKGTNESL	ERQMREMEEN	FAVEAANYQD
370	380	390	400	410	420
TIGRLQDEIQ	NMKEEMARHL	REYQDLLNVK	MALDIEIATY	RKLLEGEESR	ISLPLPNFSS
430	440	450	460
LNLRETNLDS	LPLVDTHSKR	TLLIKTVETR	DGQVINETSQ	HHDDLE