AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

358-456 (Predicted disordered autoinhibitory region) PR

358-456 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P21619-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389115114	67	V>E	No	EVA
rs45713754	143	T>A	No	EVA
rs3389125160	275	D>G	No	EVA
rs243330100	279	H>R	No	EVA
rs3389127619	280	A>T	No	EVA
rs3389104130	291	R>H	No	EVA
rs3389082739	293	E>*	No	EVA
rs3389093814	299	L>P	No	EVA
rs3389114681	318	E>*	No	EVA
rs3389125177	356	L>M	No	EVA
rs3389104143	361	A>T	No	EVA
rs3389114623	369	Y>F	No	EVA
rs241448295	430	R>S	No	EVA
rs227358059	444	T>A	No	EVA
rs3389108160	466	N>Y	No	EVA
rs3389082815	483	V>D	No	EVA
rs3389104154	484	L>R	No	EVA
rs3389093797	492	K>E	No	EVA
rs225673732	512	A>T	No	EVA
rs3389108148	514	A>T	No	EVA
rs3413058741	523	V>M	No	EVA
rs254713694	528	T>A	No	EVA
rs244105319	529	N>S	No	EVA
rs3411747128	544	D>V	No	EVA
rs238868582	558	V>A	No	EVA
rs3389125182	559	Q>*	No	EVA
rs3389058049	587	R>S	No	EVA

Type	Name	Position	InterPro Accession
domain	Lamin tail domain	428 - 545	IPR001322
conserved_site	Intermediate filament protein, conserved site	373 - 381	IPR018039
domain	Intermediate filament, rod domain	30 - 387	IPR039008

		Description
EC Number
Subcellular Localization	Nucleus lamina
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
lamin filament	Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear lamina	The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
structural constituent of cytoskeleton	The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.

Name	Definition
heterochromatin assembly	An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.
nuclear envelope organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
nuclear migration	The directed movement of the nucleus to a specific location within a cell.
nuclear pore localization	Any process in which nuclear pores are transported to, or maintained in, a specific location.
protein localization to nuclear envelope	A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P02545	LMNA	Prelamin-A/C	Homo sapiens (Human)	PR
P17661	DES	Desmin	Homo sapiens (Human)	PR
P08670	VIM	Vimentin	Homo sapiens (Human)	PR
P31001	Des	Desmin	Mus musculus (Mouse)	PR
P20152	Vim	Vimentin	Mus musculus (Mouse)	PR
P48678	Lmna	Prelamin-A/C	Mus musculus (Mouse)	PR
P14733	Lmnb1	Lamin-B1	Mus musculus (Mouse)	PR
P70615	Lmnb1	Lamin-B1	Rattus norvegicus (Rat)	PR
P48679	Lmna	Prelamin-A/C	Rattus norvegicus (Rat)	PR
Q21065	ifa-3	Intermediate filament protein ifa-3	Caenorhabditis elegans	PR