AiPD: Autoinhibited Protein Database

A6NMX2

Gene name	EIF4E1B
Protein name	Eukaryotic translation initiation factor 4E type 1B
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:253314
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-76 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for A6NMX2

Entry ID	Method	Resolution	Chain	Position	Source
AF-A6NMX2-F1	Predicted				AlphaFoldDB

234 variants for A6NMX2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA362265171 rs1161156440	2	L>F		No	ClinGen gnomAD
CA362265205 rs1456665243	4	V>I		No	ClinGen gnomAD
CA362265208 rs1456665243	4	V>L		No	ClinGen gnomAD
CA362265248 rs1351122391	5	E>D		No	ClinGen gnomAD
CA362265242 rs1323606026	5	E>V		No	ClinGen gnomAD
rs1213995384 CA362265386	6	V>L		No	ClinGen TOPMed gnomAD
rs781279936 CA3572377	7	S>N		No	ClinGen ExAC TOPMed gnomAD
rs781279936 CA362265397	7	S>T		No	ClinGen ExAC TOPMed gnomAD
CA131882802 rs1019312901	9	A>G		No	ClinGen Ensembl
rs900958550 CA131882803	10	E>Q		No	ClinGen Ensembl
rs1561910516 CA362265445	10	E>V		No	ClinGen Ensembl
CA362265477 rs1445863382	12	G>E		No	ClinGen TOPMed
rs1446506394 CA362265497	13	I>L		No	ClinGen gnomAD
rs114992074 CA3572379	13	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1342984580 CA362265517	14	R>*		No	ClinGen TOPMed gnomAD
CA362265515 rs1342984580	14	R>G		No	ClinGen TOPMed gnomAD
CA362265524 rs73332163	14	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs73332163 CA3572380	14	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	15	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1272748512 CA362265553	16	W>R		No	ClinGen TOPMed gnomAD
rs774936946 CA362265617	19	E>A		No	ClinGen ExAC gnomAD
CA3572385 rs774936946	19	E>G		No	ClinGen ExAC gnomAD
CA3572384 rs201972753	19	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	20	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759996438 CA3572387	20	E>K		No	ClinGen ExAC TOPMed
rs73806058 CA3572388	21	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed
rs775713860 CA3572389	21	K>N		No	ClinGen ExAC gnomAD
rs762488024	21	K>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA362265704 rs1456677911	25	A>T		No	ClinGen TOPMed
rs1450775045 CA362265738	26	A>V		No	ClinGen gnomAD
CA362265773 rs1186194856	28	R>S		No	ClinGen gnomAD
CA362265769 rs1245360884	28	R>T		No	ClinGen TOPMed
CA3572391 rs767320217	29	T>M		No	ClinGen ExAC TOPMed gnomAD
CA3572392 rs767320217	29	T>R		No	ClinGen ExAC TOPMed gnomAD
CA362265797 rs1173485960	30	P>A		No	ClinGen TOPMed gnomAD
CA362265796 rs1173485960	30	P>T		No	ClinGen TOPMed gnomAD
rs1468649643 CA362265831	32	G>R		No	ClinGen gnomAD
TCGA novel	33	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369219894 CA3572396	34	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1581186780 CA362265890	36	P>T		No	ClinGen Ensembl
CA131882940 rs940779961	37	N>D		No	ClinGen TOPMed gnomAD
rs1326023499 CA362265959	39	P>R		No	ClinGen gnomAD
rs751278327 CA3572399	39	P>S		No	ClinGen ExAC
rs1234279209 CA362265981	41	T>A		No	ClinGen TOPMed gnomAD
CA3572400 rs756406076	41	T>I		No	ClinGen ExAC gnomAD
CA362265984 rs1234279209	41	T>S		No	ClinGen TOPMed gnomAD
rs899559206 CA131882976	42	L>F		No	ClinGen TOPMed
CA3572401 rs777820315	43	L>P		No	ClinGen ExAC gnomAD
CA131882997 rs996610932	44	S>C		No	ClinGen TOPMed gnomAD
CA362266015 rs996610932	44	S>F		No	ClinGen TOPMed gnomAD
rs1156505496 CA362266021	45	L>R		No	ClinGen gnomAD
CA362266044 rs1402589417	47	G>V		No	ClinGen TOPMed
rs1466227983 CA362266066	49	A>T		No	ClinGen gnomAD
rs117586833 CA3572403	50	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3572402 rs749386549	50	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3572405 rs779126438	51	T>K		No	ClinGen ExAC TOPMed gnomAD
rs779126438 COSM300286 CA3572407	51	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs775973116 CA362266114	52	G>E		No	ClinGen ExAC TOPMed gnomAD
CA362266112 rs1200569664	52	G>R		No	ClinGen gnomAD
rs775973116 CA3572409	52	G>V		No	ClinGen ExAC TOPMed gnomAD
rs751393132	53	G>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA3572412 rs780180060	53	G>D		No	ClinGen ExAC TOPMed gnomAD
rs747289836 CA3572410	53	G>S		No	ClinGen ExAC TOPMed gnomAD
CA3572411 rs780180060	53	G>V		No	ClinGen ExAC TOPMed gnomAD
CA362266141 rs772701144 CA3572415	55	M>L		No	ClinGen ExAC gnomAD
CA3572416 rs762984605	55	M>T		No	ClinGen ExAC gnomAD
CA362266190 rs1316862965	59	L>M		No	ClinGen TOPMed
rs1387508185 CA362266213	61	L>P		No	ClinGen gnomAD
TCGA novel	62	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA131883062 rs942366045	62	H>Y		No	ClinGen Ensembl
rs1329632376 CA362266234	63	P>L		No	ClinGen gnomAD
rs751404509 CA3572418	65	Q>K		No	ClinGen ExAC TOPMed
rs1040708758 CA362266270	66	N>K		No	ClinGen TOPMed gnomAD
CA3572419 rs754665422	67	R>K		No	ClinGen ExAC TOPMed gnomAD
CA3572443 CA131883384 rs750550082	67	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1169456790 CA362266925	69	A>V		No	ClinGen gnomAD
rs780623437 CA3572444	71	W>*		No	ClinGen ExAC TOPMed gnomAD
rs1297442648 CA362266950	71	W>*		No	ClinGen gnomAD
rs1397748831 CA362267010	74	K>E		No	ClinGen gnomAD
CA3572445 rs752064162	74	K>M		No	ClinGen ExAC TOPMed gnomAD
rs752064162 CA362267015	74	K>R		No	ClinGen ExAC TOPMed gnomAD
CA131883399 rs199787356	77	R>C		No	ClinGen ExAC gnomAD
CA3572447 rs373687912	77	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199787356 CA3572446	77	R>S		No	ClinGen ExAC gnomAD
TCGA novel	79	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA131883405 rs756896801	79	R>Q		No	ClinGen TOPMed gnomAD
rs765322594 CA3572448	79	R>W	Variant assessed as Somatic; 0.0001427 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA362267115 rs1561910913	80	A>S		No	ClinGen Ensembl
rs982779454 CA131883409	80	A>V		No	ClinGen TOPMed
rs1352978214 CA362267142	82	Q>K		No	ClinGen TOPMed
CA3572449 rs367830438	82	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1581187065 CA362267160	83	D>G		No	ClinGen Ensembl
rs1483840642 CA362267170	84	N>Y		No	ClinGen gnomAD
CA3572450 rs777342115	85	L>M		No	ClinGen ExAC gnomAD
CA362267192 rs1420205702	85	L>Q		No	ClinGen TOPMed
CA3572452 rs770409222	86	H>N		No	ClinGen ExAC gnomAD
CA362267205 rs770409222	86	H>Y		No	ClinGen ExAC gnomAD
CA131883425 rs367869260	87	L>V		No	ClinGen Ensembl
rs1189346100 CA362267229	88	V>I		No	ClinGen gnomAD
CA362267256 rs1156603792	89	T>I		No	ClinGen TOPMed
CA131883426 rs561940055	90	K>N		No	ClinGen 1000Genomes
COSM3365992 rs1408455034 CA362267281	91	V>M	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
CA3572453 rs773912010	92	D>N		No	ClinGen ExAC gnomAD
TCGA novel	93	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3572455 rs772113105	94	V>A		No	ClinGen ExAC TOPMed gnomAD
CA362267367 rs1382029630	95	E>K		No	ClinGen gnomAD
CA3572458 rs765558809	96	D>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	97	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362267498 rs750551455	99	A>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs750551455 CA3572459	99	A>V		No	ClinGen ExAC TOPMed gnomAD
rs980489223 CA131884139	100	L>I		No	ClinGen TOPMed gnomAD
rs1428374253 CA362267714	101	Y>C		No	ClinGen gnomAD
CA362267749 rs1472838264	102	S>N		No	ClinGen gnomAD
rs1161270162 CA362267765	103	H>R		No	ClinGen gnomAD
rs1399585413 CA362267799	105	Q>*		No	ClinGen gnomAD
CA362267850 rs1351215062	107	A>V		No	ClinGen gnomAD
rs759570203 CA3572486	109	K>R		No	ClinGen ExAC gnomAD
rs368584564 CA3572487	110	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs752001341 CA131884158	110	L>P		No	ClinGen TOPMed
rs1420028464 CA362267945	113	G>S		No	ClinGen TOPMed
TCGA novel	115	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362268031 rs1349208093 COSM1731802	117	A>T	liver NS [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs756611934 CA362268046	118	L>F		No	ClinGen ExAC gnomAD
rs756611934 CA3572489	118	L>V		No	ClinGen ExAC gnomAD
CA131884859 rs867836421	121	D>G		No	ClinGen Ensembl
rs1561911416 CA362268226	122	G>A		No	ClinGen Ensembl
rs368333419 CA362268255	124	Q>*		No	ClinGen TOPMed gnomAD
rs368333419 CA131884880	124	Q>E		No	ClinGen TOPMed gnomAD
CA362268289 rs1182486166	125	P>S		No	ClinGen gnomAD
rs578195752 CA131884884	126	M>I		No	ClinGen 1000Genomes
CA362268334 rs1395419592	127	W>C		No	ClinGen TOPMed gnomAD
CA3572508 rs761219911	128	E>D		No	ClinGen ExAC gnomAD
CA362268395 rs764616658	130	S>I		No	ClinGen ExAC gnomAD
CA3572509 rs764616658	130	S>N		No	ClinGen ExAC gnomAD
TCGA novel	132	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3572511 rs576924607	134	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs879776215 CA131884937	134	R>W		No	ClinGen TOPMed gnomAD
rs1333271712 CA362268470	135	G>D		No	ClinGen gnomAD
CA362268495 rs1450516793	137	R>C		No	ClinGen gnomAD
CA3572513 rs750156083	137	R>H		No	ClinGen ExAC gnomAD
CA362268508 rs750156083	137	R>L		No	ClinGen ExAC gnomAD
rs1229898905 CA362268537	139	L>P		No	ClinGen gnomAD
CA362268535 rs1366153462	139	L>V		No	ClinGen gnomAD
CA362268557 rs1581187757	140	V>G		No	ClinGen Ensembl
rs1268141705 CA362268544	140	V>I		No	ClinGen gnomAD
rs1268141705 CA362268546	140	V>L		No	ClinGen gnomAD
rs1338494487 CA362268599	143	A>T		No	ClinGen gnomAD
rs758116063 CA362268643	144	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1203004622 CA362268649	145	Q>E		No	ClinGen TOPMed
CA362268675 rs1264890847	146	Q>*		No	ClinGen TOPMed gnomAD
rs867316543 CA131884984	147	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA3572517 rs115365515	147	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs867316543 CA362268697	147	R>S		No	ClinGen TOPMed gnomAD
rs1298658023 CA362268724	148	H>R		No	ClinGen TOPMed
rs1429857091 CA362268787	150	E>D		No	ClinGen gnomAD
CA3572518 rs746491387	151	L>V		No	ClinGen ExAC gnomAD
rs754894044 CA3572519	152	D>H		No	ClinGen ExAC gnomAD
rs369337202 CA3572521	153	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3572520 rs762675292	153	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA362268872 rs1336091367	155	W>C		No	ClinGen gnomAD
rs75547884 CA131885021	155	W>G		No	ClinGen Ensembl
rs1385786428 CA362268914	157	E>G		No	ClinGen gnomAD
CA3572522 rs201024089	158	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs370738911 CA3572550	159	L>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs199835250 CA3572552	161	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs974918867 CA131885272	163	I>F		No	ClinGen gnomAD
CA3572553 rs770398185	163	I>M		No	ClinGen ExAC TOPMed gnomAD
CA3572554 rs773730956 CA362269121	164	G>R		No	ClinGen ExAC TOPMed gnomAD
CA3572555 rs763370432	164	G>V		No	ClinGen ExAC gnomAD
CA362269123 rs773730956	164	G>W		No	ClinGen ExAC TOPMed gnomAD
rs766132677 CA3572556	165	E>G		No	ClinGen ExAC gnomAD
rs1423729008 CA362269127	165	E>Q		No	ClinGen gnomAD
rs1375393924 CA362269199	168	E>*		No	ClinGen gnomAD
rs534960290 CA3572557	168	E>D		No	ClinGen ExAC
CA362269223 rs1389609779	169	E>K		No	ClinGen gnomAD
rs202006112 CA3572559	170	H>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3572558 rs759107650	170	H>Y		No	ClinGen ExAC gnomAD
rs756099664 CA3572561	172	R>*		No	ClinGen ExAC TOPMed gnomAD
rs756099664 CA131885299 COSM1205140	172	R>G	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA131885303 rs954932855	176	G>E		No	ClinGen Ensembl
CA3572563 rs753638257	177	A>S		No	ClinGen ExAC gnomAD
rs756991362 CA3572564	178	V>I		No	ClinGen ExAC gnomAD
CA362269403 rs1250509685	179	V>I		No	ClinGen TOPMed gnomAD
rs778668845 CA3572565	182	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1395285185 CA362269491	184	K>T		No	ClinGen TOPMed
rs1404364899 CA362269508	185	G>R		No	ClinGen gnomAD
CA3572569 rs201530441	186	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA362269516 rs755120311	186	D>N		No	ClinGen ExAC TOPMed gnomAD
rs755120311 CA3572568	186	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1036553652 CA131885360	187	K>E		No	ClinGen TOPMed
CA362269562 rs1297537373	189	A>D		No	ClinGen gnomAD
CA131885374 rs796378834	189	A>T		No	ClinGen Ensembl
rs1406791263 CA362269565	190	V>M		No	ClinGen gnomAD
CA131885390 rs994577136	191	W>C		No	ClinGen TOPMed
rs937813392 CA131885379	191	W>R		No	ClinGen Ensembl
rs1454100556 CA362269596	192	T>M		No	ClinGen gnomAD
rs770455070 CA3572571	193	R>G		No	ClinGen ExAC gnomAD
rs773788240 CA3572573	193	R>S		No	ClinGen ExAC TOPMed gnomAD
CA362269601 rs1220821576	193	R>T		No	ClinGen TOPMed gnomAD
CA362269633 rs1296660855	195	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA362269679 rs1353665250	198	Q>E		No	ClinGen TOPMed
rs368686706 CA3572575	199	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs759283330 COSM3786926 CA3572576	199	A>V	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1048115730 COSM1436180 CA131885489	201	V>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA3572580 rs116717121	204	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3572606 rs182336246	206	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3572607 rs369631741	206	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA3572608 rs369631741	206	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA362270465 rs1581188357	208	Y>C		No	ClinGen Ensembl
rs752860930 CA131886008	211	R>C		No	ClinGen gnomAD
CA3572609 rs756399527	211	R>H		No	ClinGen ExAC TOPMed gnomAD
CA3572612 rs757870734	213	G>D		No	ClinGen ExAC gnomAD
CA3572611 rs753922679	213	G>S		No	ClinGen ExAC gnomAD
rs757870734 CA362270527	213	G>V		No	ClinGen ExAC gnomAD
rs779221982 CA3572613	218	T>I		No	ClinGen ExAC gnomAD
CA3572614 rs746260963	220	I>T		No	ClinGen ExAC TOPMed gnomAD
rs772381239 CA362270629 CA3572615	221	G>R		No	ClinGen ExAC gnomAD
rs1405183279 CA362270650	222	Y>F		No	ClinGen gnomAD
CA362270679 rs1581188400	224	A>P		No	ClinGen Ensembl
rs780464331 CA3572616	224	A>V		No	ClinGen ExAC gnomAD
CA362270697 rs1426925480	225	H>P		No	ClinGen gnomAD
rs746706986 CA3572618	226	A>E		No	ClinGen ExAC gnomAD
rs746706986 CA3572617	226	A>V		No	ClinGen ExAC gnomAD
CA131886057 VAR_044209 rs13163938	227	D>Y		No	ClinGen UniProt Ensembl dbSNP
TCGA novel	229	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362270749 rs1281293464	230	T>I		No	ClinGen gnomAD
TCGA novel	231	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3572620 rs543131273	232	S>G		No	ClinGen 1000Genomes ExAC gnomAD
rs761268817 CA3572621	238	N>D		No	ClinGen ExAC TOPMed gnomAD
CA362270827 rs1361923332	238	N>S		No	ClinGen gnomAD
rs1219914553 CA362270851	240	F>Y		No	ClinGen gnomAD
rs13183830 CA131886078	242	V>G		No	ClinGen Ensembl
CA362270868 rs1288916888	242	V>M		No	ClinGen TOPMed gnomAD
rs1561912090 CA564461632	243	V>L		No	ClinGen Ensembl

No associated diseases with A6NMX2

1 regional properties for A6NMX2

Type	Name	Position	InterPro Accession
conserved_site	Eukaryotic translation initiation factor 4E (eIF-4E), conserved site	115 - 138	IPR019770

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
eukaryotic translation initiation factor 4F complex	The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
mRNA cap binding complex	Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.

2 GO annotations of molecular function

Name	Definition
RNA 7-methylguanosine cap binding	Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
translation initiation factor activity	Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q03389		Eukaryotic translation initiation factor isoform 4E-2	Triticum aestivum (Wheat)	PR
P07260	CDC33	Eukaryotic translation initiation factor 4E	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q8N5X7	EIF4E3	Eukaryotic translation initiation factor 4E type 3	Homo sapiens (Human)	PR
O60573	EIF4E2	Eukaryotic translation initiation factor 4E type 2	Homo sapiens (Human)	PR
P06730	EIF4E	Eukaryotic translation initiation factor 4E	Homo sapiens (Human)	PR
O81482		Eukaryotic translation initiation factor isoform 4E-2	Zea mays (Maize)	PR
P63073	Eif4e	Eukaryotic translation initiation factor 4E	Mus musculus (Mouse)	PR
O61955	ife-3	Eukaryotic translation initiation factor 4E-3	Caenorhabditis elegans	PR
Q9C7P6	EIF4E3	Eukaryotic translation initiation factor 4E-3	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MLAVEVSEAE	GGIREWEEEE	KEEEAAERTP	TGEKSPNSPR	TLLSLRGKAR	TGGPMEVKLE
70	80	90	100	110	120
LHPLQNRWAL	WFFKNDRSRA	WQDNLHLVTK	VDTVEDFWAL	YSHIQLASKL	SSGCDYALFK
130	140	150	160	170	180
DGIQPMWEDS	RNKRGGRWLV	SLAKQQRHIE	LDRLWLETLL	CLIGESFEEH	SREVCGAVVN
190	200	210	220	230	240
IRTKGDKIAV	WTREAENQAG	VLHVGRVYKE	RLGLSPKTII	GYQAHADTAT	KSNSLAKNKF

VV