Q9C7P6

PR
Gene name
EIF4E3
Protein name
Eukaryotic translation initiation factor 4E-3
Names
eIF-4E-3, eIF4E-3, mRNA cap-binding protein
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G29550
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9C7P6

Entry ID Method Resolution Chain Position Source
AF-Q9C7P6-F1 Predicted AlphaFoldDB

11 variants for Q9C7P6

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04665686 26 S>N No 1000Genomes
ENSVATH04665687 27 P>S No 1000Genomes
tmp_1_10330653_A_C 47 K>T No 1000Genomes
ENSVATH12297568 50 K>Q No 1000Genomes
tmp_1_10330761_A_G 83 N>S No 1000Genomes
tmp_1_10331356_G_A 147 M>I No 1000Genomes
tmp_1_10331379_G_T 155 C>F No 1000Genomes
ENSVATH04665700 218 T>K No 1000Genomes
ENSVATH12297642 222 I>L No 1000Genomes
ENSVATH04665702 226 D>E No 1000Genomes
ENSVATH04665703 231 D>G No 1000Genomes

No associated diseases with Q9C7P6

No regional properties for Q9C7P6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9C7P6

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
RNA 7-methylguanosine cap binding Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
response to virus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q03389 Eukaryotic translation initiation factor isoform 4E-2 Triticum aestivum (Wheat) PR
P07260 CDC33 Eukaryotic translation initiation factor 4E Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A6NMX2 EIF4E1B Eukaryotic translation initiation factor 4E type 1B Homo sapiens (Human) PR
P06730 EIF4E Eukaryotic translation initiation factor 4E Homo sapiens (Human) PR
O81482 Eukaryotic translation initiation factor isoform 4E-2 Zea mays (Maize) PR
P63073 Eif4e Eukaryotic translation initiation factor 4E Mus musculus (Mouse) PR
O61955 ife-3 Eukaryotic translation initiation factor 4E-3 Caenorhabditis elegans PR
10 20 30 40 50 60
MVVTDSPVSG IMADQNIDPN TTTSPSPKEK HVSAIKAISG DEKAPSKEKK NYASKKSTTV
70 80 90 100 110 120
IQKSHCFQNS WTFWFDNPSS KSNQVIWGSS LRSLYTFGTI EEFWSLYNNI HPPTKWVSGA
130 140 150 160 170 180
DLYCFKDKIE PKWEDPICAN GGKWSMMFPK ATLECNWLNT LLALVGEQFD QGDEICGAVL
190 200 210 220 230
NFRARGDRIS LWTKNAANEE AQLSIGKQWK ELLGYNETIG FIVHEDAKTL DRDAKRRYTV