O81482

PR
Gene name
Protein name
Eukaryotic translation initiation factor isoform 4E-2
Names
eIF(iso)-4E-2, eIF(iso)4E-2, eIF-(iso)4F 25 kDa subunit, eIF-(iso)4F p28 subunit, mRNA cap-binding protein
Species
Zea mays (Maize)
KEGG Pathway
zma:541708
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O81482

Entry ID Method Resolution Chain Position Source
AF-O81482-F1 Predicted AlphaFoldDB

6 variants for O81482

Variant ID(s) Position Change Description Diseaes Association Provenance
PZE0529617868 16 A>S No EnsemblPlants
PZE0529617856 20 T>P No EnsemblPlants
PZE0529614092 94 N>S No EnsemblPlants
PZE0529613794 154 I>V No EnsemblPlants
PZE0529613776 160 A>S No EnsemblPlants
PZE0529613012 190 D>H No EnsemblPlants

No associated diseases with O81482

3 regional properties for O81482

Type Name Position InterPro Accession
domain Target SNARE coiled-coil homology domain 190 - 282 IPR000727
domain Syntaxin, N-terminal domain 27 - 230 IPR006011
conserved_site Syntaxin/epimorphin, conserved site 201 - 240 IPR006012

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.

2 GO annotations of molecular function

Name Definition
RNA 7-methylguanosine cap binding Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q03389 Eukaryotic translation initiation factor isoform 4E-2 Triticum aestivum (Wheat) PR
P07260 CDC33 Eukaryotic translation initiation factor 4E Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A6NMX2 EIF4E1B Eukaryotic translation initiation factor 4E type 1B Homo sapiens (Human) PR
P06730 EIF4E Eukaryotic translation initiation factor 4E Homo sapiens (Human) PR
P63073 Eif4e Eukaryotic translation initiation factor 4E Mus musculus (Mouse) PR
O61955 ife-3 Eukaryotic translation initiation factor 4E-3 Caenorhabditis elegans PR
Q9C7P6 EIF4E3 Eukaryotic translation initiation factor 4E-3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAEVEAPATA VEAPAAAVAT TTPEVAAPEA GAATEAKGPH KLHRQWTFWY DIQTKTKSGA
70 80 90 100 110 120
AWGTSLKKAY TFDTVEEFWS MYDQIFRPSK LSGNADFHLF KAGVEPKWED PECANGGKWT
130 140 150 160 170 180
VPCNRKATFE TMWLETLMAL IGEQFDETED ICGIVASVRA RGDKLALWTR TASNEAVQVN
190 200 210
IGKKWKDVID YNDKITYTFH DDSKRDKPSR GGRYTV