Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q03389
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q03389-F1 | Predicted | AlphaFoldDB |
1 variants for Q03389
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 22 | G>S | No |
No associated diseases with Q03389
1 regional properties for Q03389
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Eukaryotic translation initiation factor 4E (eIF-4E), conserved site | 89 - 112 | IPR019770 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| eukaryotic translation initiation factor 4F complex | The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA 7-methylguanosine cap binding | Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| response to stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A3RCV9 | NCBP | Eukaryotic translation initiation factor NCBP | Triticum aestivum (Wheat) | PR |
| P07260 | CDC33 | Eukaryotic translation initiation factor 4E | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P06730 | EIF4E | Eukaryotic translation initiation factor 4E | Homo sapiens (Human) | PR |
| A6NMX2 | EIF4E1B | Eukaryotic translation initiation factor 4E type 1B | Homo sapiens (Human) | PR |
| O81482 | Eukaryotic translation initiation factor isoform 4E-2 | Zea mays (Maize) | PR | |
| P63073 | Eif4e | Eukaryotic translation initiation factor 4E | Mus musculus (Mouse) | PR |
| O61955 | ife-3 | Eukaryotic translation initiation factor 4E-3 | Caenorhabditis elegans | PR |
| Q9C7P6 | EIF4E3 | Eukaryotic translation initiation factor 4E-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEVEAALPV | AATETPEVAA | EGDAGAAEAK | GPHKLQRQWT | FWYDIQTKPK | PGAAWGTSLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KGYTFDTVEE | FWCLYDQIFR | PSKLVGSADF | HLFKAGVEPK | WEDPECANGG | KWTVISSRKT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLDTMWLETC | MALIGEQFDE | SQEICGVVAS | VRQRQDKLSL | WTKTASNEAV | QVDIGKKWKE |
| 190 | 200 | ||||
| VIDYNDKMVY | SFHDDSRSQK | PSRGGRYTV |