O61955
Gene name |
ife-3 |
Protein name |
Eukaryotic translation initiation factor 4E-3 |
Names |
eIF-4E-3, eIF4E-3, eIF-4F 25 kDa subunit, mRNA cap-binding protein |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_B0348.6 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for O61955
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5ABX | X-ray | 166 A | A | 30-215 | PDB |
| 5ABY | X-ray | 195 A | A/C/E | 30-215 | PDB |
| AF-O61955-F1 | Predicted | AlphaFoldDB |
No variants for O61955
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O61955 | |||||
No associated diseases with O61955
2 regional properties for O61955
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | UbiE/COQ5 methyltransferase, conserved site | 36 - 51 | IPR023576-1 |
| conserved_site | UbiE/COQ5 methyltransferase, conserved site | 158 - 172 | IPR023576-2 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| eukaryotic translation initiation factor 4F complex | The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| RNA cap binding complex | Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. |
| translation initiation complex | A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA 7-methylguanosine cap binding | Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| 21U-RNA metabolic process | The chemical reactions and pathways involving 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome. |
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q03389 | Eukaryotic translation initiation factor isoform 4E-2 | Triticum aestivum (Wheat) | PR | |
| P07260 | CDC33 | Eukaryotic translation initiation factor 4E | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A6NMX2 | EIF4E1B | Eukaryotic translation initiation factor 4E type 1B | Homo sapiens (Human) | PR |
| P06730 | EIF4E | Eukaryotic translation initiation factor 4E | Homo sapiens (Human) | PR |
| O81482 | Eukaryotic translation initiation factor isoform 4E-2 | Zea mays (Maize) | PR | |
| P63073 | Eif4e | Eukaryotic translation initiation factor 4E | Mus musculus (Mouse) | PR |
| Q22888 | ife-4 | Eukaryotic translation initiation factor 4E-4 | Caenorhabditis elegans | PR |
| Q9C7P6 | EIF4E3 | Eukaryotic translation initiation factor 4E-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTSVAENKA | LSASGDVNAS | DASVPPELLT | RHPLQNRWAL | WYLKADRNKE | WEDCLKMVSL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FDTVEDFWSL | YNHIQSAGGL | NWGSDYYLFK | EGIKPMWEDV | NNVQGGRWLV | VVDKQKLQRR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TQLLDHYWLE | LLMAIVGEQF | DEYGDYICGA | VVNVRQKGDK | VSLWTRDATR | DDVNLRIGQV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKQKLSIPDT | EILRYEVHKD | SSARTSSTVK | PRICLPAKDP | APVKEKGPAA | TTSPSNPGTE |
| 250 | |||||
| ATGTSPATPT | P |