Q22888
Gene name |
ife-4 (C05D9.5) |
Protein name |
Eukaryotic translation initiation factor 4E-4 |
Names |
eIF-4E-4, eIF4E-4, eIF-4F 25 kDa subunit, mRNA cap-binding protein |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C05D9.5 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q22888
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q22888-F1 | Predicted | AlphaFoldDB |
No variants for Q22888
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q22888 | |||||
No associated diseases with Q22888
4 regional properties for Q22888
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Signal recognition particle, SRP54 subunit, GTPase domain | 101 - 296 | IPR000897 |
| domain | AAA+ ATPase domain | 100 - 277 | IPR003593 |
| domain | Signal recognition particle, SRP54 subunit, M-domain | 326 - 431 | IPR004125 |
| domain | Signal recognition particle SRP54, helical bundle | 2 - 87 | IPR013822 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| eukaryotic translation initiation factor 4F complex | The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA 7-methylguanosine cap binding | Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A3RCV9 | NCBP | Eukaryotic translation initiation factor NCBP | Triticum aestivum (Wheat) | PR |
| O60573 | EIF4E2 | Eukaryotic translation initiation factor 4E type 2 | Homo sapiens (Human) | PR |
| Q8BMB3 | Eif4e2 | Eukaryotic translation initiation factor 4E type 2 | Mus musculus (Mouse) | PR |
| Q10NQ9 | NCBP | Eukaryotic translation initiation factor NCBP | Oryza sativa subsp japonica (Rice) | PR |
| O61955 | ife-3 | Eukaryotic translation initiation factor 4E-3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAETSTQEV | VKQVKNLPIL | MEDAPVGSDD | HQLQYSYTFS | YFMRPTGKFD | PEDYASYVQP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGIMKSVEQF | WSIMVHFKRP | TEMCDKADIH | FFKTGVKPVW | EDPANCKGGK | WIIRLKKGLS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TRIWENLLMA | IIGEQFLVGD | ELCGAVCSIR | NQEDIISLWN | RNADDTPVTN | RIRETLRSVL |
| 190 | 200 | 210 | |||
| QLPQNTVLEY | KRHDDCLRDQ | SSYRHTTKNI | CK |