O60573
PR
Gene name |
EIF4E2 |
Protein name |
Eukaryotic translation initiation factor 4E type 2 |
Names |
eIF-4E type 2, eIF4E type 2, Eukaryotic translation initiation factor 4E homologous protein, Eukaryotic translation initiation factor 4E-like 3, eIF4E-like protein 4E-LP, mRNA cap-binding protein 4EHP, h4EHP, mRNA cap-binding protein type 3 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:9470 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
8 structures for O60573
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2JGB | X-ray | 170 A | A | 45-234 | PDB |
| 2JGC | X-ray | 240 A | A | 45-234 | PDB |
| 5NVK | X-ray | 290 A | A/C/E/G | 52-234 | PDB |
| 5NVL | X-ray | 230 A | A/C | 52-234 | PDB |
| 5NVM | X-ray | 200 A | A/C | 52-234 | PDB |
| 5NVN | X-ray | 190 A | A/C | 52-234 | PDB |
| 5XLN | X-ray | 190 A | A | 45-234 | PDB |
| AF-O60573-F1 | Predicted | AlphaFoldDB |
145 variants for O60573
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA66977034 rs1000310952 |
2 | N>D | No |
ClinGen TOPMed |
|
|
rs376291567 CA2169233 |
2 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs370961236 CA66977040 |
3 | N>K | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs746185124 CA2169234 |
4 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746185124 CA351025553 |
4 | K>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351025557 rs1488539412 |
4 | K>T | No |
ClinGen TOPMed |
|
|
CA351025567 rs1559309972 |
5 | F>L | No |
ClinGen Ensembl |
|
|
rs1263897796 CA351025595 |
7 | A>V | No |
ClinGen Ensembl |
|
| TCGA novel | 15 | D>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA351026497 rs1484283179 |
16 | H>N | No |
ClinGen gnomAD |
|
|
rs764241412 CA2169268 |
18 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA351026555 rs1446106738 |
23 | S>N | No |
ClinGen gnomAD |
|
| TCGA novel | 25 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs374300851 CA66979620 |
27 | D>V | No |
ClinGen ESP TOPMed |
|
|
rs1391957620 CA351026593 |
28 | G>A | No |
ClinGen TOPMed gnomAD |
|
|
CA351026592 rs1391957620 |
28 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA351026589 rs1166735631 |
28 | G>S | No |
ClinGen gnomAD |
|
|
CA66979628 rs200634717 |
31 | E>G | No |
ClinGen Ensembl |
|
|
rs750915667 CA2169272 |
33 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA2169273 rs377735542 |
33 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA351026638 rs370171571 |
35 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs149079029 CA2169276 COSM300867 |
35 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed |
|
CA351026644 rs1280343327 |
36 | D>Y | No |
ClinGen TOPMed |
|
|
CA2169278 rs747719438 |
37 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351026655 rs1343680411 |
37 | K>N | No |
ClinGen TOPMed |
|
|
CA351026674 rs1282778546 |
40 | S>G | No |
ClinGen TOPMed |
|
|
CA351026690 rs1342239129 |
42 | S>G | No |
ClinGen gnomAD |
|
|
rs1229847307 CA351026703 COSM3798751 |
43 | K>N | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs969802613 CA66979667 |
44 | R>G | No |
ClinGen TOPMed |
|
|
CA351026753 rs1270201270 |
48 | V>A | No |
ClinGen gnomAD |
|
|
CA2169300 rs148255880 |
51 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2169301 rs148255880 |
51 | P>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2169303 rs370882938 |
52 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs769552669 CA2169305 |
55 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2169306 rs774592191 |
59 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs367941662 CA2169307 |
60 | Y>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2169308 rs772130461 |
61 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA66980240 rs919552473 |
63 | W>C | No |
ClinGen TOPMed |
|
|
CA351026845 rs1468847558 |
63 | W>R | No |
ClinGen gnomAD |
|
|
rs1483687915 CA351026890 |
69 | P>R | No |
ClinGen TOPMed |
|
|
rs754375724 CA351026977 |
70 | G>C | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 70 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs754375724 CA2169312 |
70 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351026994 rs1450895082 |
71 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
CA351027004 rs1350302193 |
72 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA351027002 rs1350302193 |
72 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA351027036 rs758136547 |
74 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2169316 rs758136547 |
74 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs896597825 CA66980263 |
77 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
CA351027108 rs1559314210 |
78 | Y>C | No |
ClinGen Ensembl |
|
|
rs912300763 CA66980268 |
80 | Q>* | No |
ClinGen TOPMed |
|
| TCGA novel | 82 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs200177620 CA66980269 |
86 | G>D | No |
ClinGen 1000Genomes |
|
|
rs554396964 CA66980275 |
87 | T>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2169321 rs554396964 |
87 | T>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA66980273 rs554396964 |
87 | T>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA66980277 rs1039939878 |
90 | S>F | No |
ClinGen TOPMed |
|
| TCGA novel | 90 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1340125618 CA351028187 |
92 | E>* | No |
ClinGen gnomAD |
|
|
CA351028210 rs1230584101 |
94 | F>Y | No |
ClinGen gnomAD |
|
|
CA66982991 rs1019418374 |
96 | R>G | No |
ClinGen TOPMed |
|
|
CA351028255 rs1275231663 |
98 | Y>C | No |
ClinGen gnomAD |
|
|
CA2169349 rs745875029 |
99 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2169350 rs376155648 |
101 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2169351 rs142409429 COSM1017846 |
103 | R>C | endometrium [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs921725664 CA66982995 |
103 | R>H | No |
ClinGen gnomAD |
|
|
CA2169354 rs774733717 |
107 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 113 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs868260001 CA66983002 |
114 | H>N | No |
ClinGen Ensembl |
|
| TCGA novel | 115 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs199658288 CA66983005 |
115 | L>P | No |
ClinGen 1000Genomes |
|
|
rs1161757288 CA351028437 |
116 | F>S | No |
ClinGen gnomAD |
|
|
rs767095876 CA2169356 |
118 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs373307064 CA2169357 |
120 | I>T | No |
ClinGen ESP ExAC gnomAD |
|
|
CA2169367 rs781558692 |
128 | A>E | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 131 | N>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2169368 rs746001988 |
132 | G>D | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 135 | W>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs749786793 COSM1017848 CA2169371 |
140 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA2169370 rs374014488 |
140 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351028640 rs1462990064 |
143 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1356634902 CA351028647 |
144 | A>V | No |
ClinGen TOPMed |
|
|
CA351028649 rs1340876805 |
145 | S>P | No |
ClinGen gnomAD |
|
|
rs770708405 CA2169372 |
146 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770708405 CA351028655 |
146 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2169373 rs572423747 |
146 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs770708405 CA351028654 |
146 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA66984138 rs1052606617 |
147 | C>* | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 148 | W>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2169375 rs771772092 |
154 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA2169376 rs772833654 |
155 | M>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA2169377 rs371244654 |
163 | G>E | No |
ClinGen ESP ExAC gnomAD |
|
|
CA351028774 rs1181822248 |
163 | G>W | No |
ClinGen gnomAD |
|
|
CA2169378 rs765905383 |
169 | A>S | No |
ClinGen ExAC gnomAD |
|
|
COSM1482866 rs375938541 CA66984163 |
169 | A>V | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP NCI-TCGA TOPMed |
|
rs541446786 CA2169379 |
173 | V>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 174 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1334361342 CA351028875 |
176 | Q>H | No |
ClinGen TOPMed |
|
|
CA66984288 rs985378904 |
179 | I>V | No |
ClinGen Ensembl |
|
|
rs1030157287 CA66984289 |
181 | S>L | No |
ClinGen TOPMed |
|
|
rs1228378612 CA351028980 |
183 | W>* | No |
ClinGen gnomAD |
|
|
CA351029001 rs1207114203 |
184 | N>K | No |
ClinGen Ensembl |
|
|
CA2169405 rs756415940 |
187 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA66984296 rs758776611 |
188 | S>G | No |
ClinGen gnomAD |
|
| TCGA novel | 190 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA66984302 rs369451659 |
191 | A>T | No |
ClinGen ESP TOPMed |
|
|
rs753926454 CA2169407 |
194 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs374189895 CA2169408 |
195 | R>* | No |
ClinGen ESP ExAC gnomAD |
|
|
CA66984313 rs964360849 COSM1017849 |
195 | R>Q | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
rs1253747485 CA351029122 |
197 | R>Q | No |
ClinGen gnomAD |
|
|
CA351029161 rs1391895774 |
201 | R>Q | No |
ClinGen gnomAD |
|
|
CA66984324 rs925320031 |
201 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA2169409 rs779332394 |
204 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1288877022 CA351029236 |
209 | N>S | No |
ClinGen TOPMed |
|
|
CA351029251 rs1559319463 |
211 | I>V | No |
ClinGen Ensembl |
|
|
rs1574671136 CA351029266 |
212 | M>R | No |
ClinGen Ensembl |
|
|
rs1363860370 CA351029303 |
215 | K>R | No |
ClinGen gnomAD |
|
|
CA66984338 rs918117025 |
219 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA351029792 rs1414468943 |
223 | M>T | No |
ClinGen TOPMed |
|
|
rs752842206 CA2169445 |
226 | R>M | No |
ClinGen ExAC gnomAD |
|
|
CA2169446 rs149648709 |
226 | R>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA351029817 rs1183575423 |
227 | L>P | No |
ClinGen TOPMed |
|
|
rs565444213 CA351029826 |
229 | P>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs565444213 CA2169447 |
229 | P>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA351029831 rs1408289634 |
230 | Q>E | No |
ClinGen gnomAD |
|
| TCGA novel | 230 | Q>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs140152833 CA2169448 |
231 | R>G | No |
ClinGen ESP ExAC gnomAD |
|
|
CA351029842 CA2169449 rs757664712 |
231 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1559320411 CA351029852 |
233 | L>P | No |
ClinGen Ensembl |
|
|
rs890432776 CA66985026 |
233 | L>V | No |
ClinGen Ensembl |
|
|
CA66985027 rs957127542 |
234 | F>L | No |
ClinGen TOPMed |
|
|
CA351029862 rs1218655810 |
235 | Q>* | No |
ClinGen gnomAD |
|
|
CA2169450 rs781636845 |
236 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1574673085 CA351029872 |
236 | N>T | No |
ClinGen Ensembl |
|
|
TCGA novel CA2169451 rs746156300 |
238 | W>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen ExAC TOPMed gnomAD |
|
CA2169453 rs779845297 |
240 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2169454 rs779845297 |
240 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2169452 rs755792001 |
240 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA2169457 rs201695304 |
241 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2169456 rs146216550 |
241 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2169458 rs771850406 |
242 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1309066936 CA351029917 |
243 | N>K | No |
ClinGen TOPMed |
|
|
CA2169460 rs760383477 |
244 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA2169459 rs773065194 |
244 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770061126 CA2169461 |
246 | P>W | No |
ClinGen ExAC gnomAD |
No associated diseases with O60573
1 regional properties for O60573
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Eukaryotic translation initiation factor 4E (eIF-4E), conserved site | 112 - 135 | IPR019770 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| eukaryotic translation initiation factor 4F complex | The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. |
| mRNA cap binding complex | Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. |
| P-body | A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA 7-methylguanosine cap binding | Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA cap binding | Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
| translation factor activity, RNA binding | Functions during translation by binding to RNA during polypeptide synthesis at the ribosome. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| miRNA-mediated gene silencing by inhibition of translation | An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs. |
| negative regulation of translation | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A3RCV9 | NCBP | Eukaryotic translation initiation factor NCBP | Triticum aestivum (Wheat) | PR |
| Q8N5X7 | EIF4E3 | Eukaryotic translation initiation factor 4E type 3 | Homo sapiens (Human) | PR |
| A6NMX2 | EIF4E1B | Eukaryotic translation initiation factor 4E type 1B | Homo sapiens (Human) | PR |
| P06730 | EIF4E | Eukaryotic translation initiation factor 4E | Homo sapiens (Human) | PR |
| Q8BMB3 | Eif4e2 | Eukaryotic translation initiation factor 4E type 2 | Mus musculus (Mouse) | PR |
| Q10NQ9 | NCBP | Eukaryotic translation initiation factor NCBP | Oryza sativa subsp japonica (Rice) | PR |
| Q22888 | ife-4 | Eukaryotic translation initiation factor 4E-4 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNNKFDALKD | DDSGDHDQNE | ENSTQKDGEK | EKTERDKNQS | SSKRKAVVPG | PAEHPLQYNY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TFWYSRRTPG | RPTSSQSYEQ | NIKQIGTFAS | VEQFWRFYSH | MVRPGDLTGH | SDFHLFKEGI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPMWEDDANK | NGGKWIIRLR | KGLASRCWEN | LILAMLGEQF | MVGEEICGAV | VSVRFQEDII |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SIWNKTASDQ | ATTARIRDTL | RRVLNLPPNT | IMEYKTHTDS | IKMPGRLGPQ | RLLFQNLWKP |
| RLNVP |