AiPD: Autoinhibited Protein Database

Gene name	OSCA1
Protein name	Protein OSCA1
Names	CSC1-like protein At4g04340, Hyperosmolality-gated Ca2+ permeable channel 1.1, AtOSCA1.1, Protein reduced hyperosmolality-induced [Ca(2+)]i increase 1
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G04340
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

662-772 (Predicted disordered autoinhibitory region) PR

662-772 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
6JPF	EM	352 A	A/B	1-772	PDB
8GRN	EM	250 A	A/B	1-772	PDB
AF-Q9XEA1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH06462206	20	I>L	No	1000Genomes
ENSVATH00461719	24	I>V	No	1000Genomes
ENSVATH00461720	55	G>D	No	1000Genomes
ENSVATH02650360	66	L>F	No	1000Genomes
ENSVATH02650359	66	L>W	No	1000Genomes
tmp_4_2123814_C_G	106	L>V	No	1000Genomes
ENSVATH10699836	110	A>S	No	1000Genomes
ENSVATH00461726	136	F>L	No	1000Genomes
ENSVATH06462219	186	N>T	No	1000Genomes
ENSVATH13927691	196	G>S	No	1000Genomes
tmp_4_2124313_C_T	211	P>L	No	1000Genomes
ENSVATH06462224	236	H>Y	No	1000Genomes
tmp_4_2124504_G_T	248	L>F	No	1000Genomes
tmp_4_2124566_A_G	269	N>S	No	1000Genomes
tmp_4_2124571_T_G	271	S>A	No	1000Genomes
tmp_4_2124586_A_T	276	I>L	No	1000Genomes
ENSVATH00461735	284	L>F	No	1000Genomes
ENSVATH10699887	320	V>I	No	1000Genomes
ENSVATH13927694	321	M>V	No	1000Genomes
ENSVATH13927735	341	T>R	No	1000Genomes
ENSVATH02650375	351	T>P	No	1000Genomes
tmp_4_2125055_T_G	377	L>W	No	1000Genomes
tmp_4_2125064_A_G	380	N>S	No	1000Genomes
tmp_4_2125317_C_T	434	A>V	No	1000Genomes
ENSVATH00461740	448	T>S	No	1000Genomes
ENSVATH06462236	499	P>A	No	1000Genomes
tmp_4_2125619_A_G	506	I>V	No	1000Genomes
ENSVATH06462240	546	N>S	No	1000Genomes
ENSVATH02650376	547	A>T	No	1000Genomes
tmp_4_2125768_C_T,A	555	D>E	No	1000Genomes
ENSVATH13927739	623	A>V	No	1000Genomes
tmp_4_2126096_C_G	635	A>G	No	1000Genomes
ENSVATH02650383	723	N>D	No	1000Genomes
ENSVATH10699939	727	G>S	No	1000Genomes
ENSVATH00461746	730	I>L	No	1000Genomes
ENSVATH00461746	730	I>V	No	1000Genomes
ENSVATH13927765	731	G>R	No	1000Genomes
ENSVATH06462253	737	V>G	No	1000Genomes
tmp_4_2126582_A_T	759	E>D	No	1000Genomes
tmp_4_2126587_C_A	761	S>Y	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	CSC1/OSCA1-like, 7TM region	375 - 647	IPR003864
domain	CSC1/OSCA1-like, cytosolic domain	201 - 364	IPR027815
domain	CSC1/OSCA1-like, N-terminal transmembrane domain	7 - 180	IPR032880

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
calcium activated cation channel activity	Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.
cation channel activity	Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

Name	Definition
cellular hyperosmotic response	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
protein tetramerization	The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
regulation of calcium ion import	Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
response to osmotic stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5T3F8	TMEM63B	CSC1-like protein 2	Homo sapiens (Human)	PR
Q9P1W3	TMEM63C	Calcium permeable stress-gated cation channel 1	Homo sapiens (Human)	PR
O94886	TMEM63A	CSC1-like protein 1	Homo sapiens (Human)	PR
Q91YT8	Tmem63a	CSC1-like protein 1	Mus musculus (Mouse)	PR
B5TYT3	At1g11960	CSC1-like protein At1g11960	Arabidopsis thaliana (Mouse-ear cress)	PR
F4HYR3	At1g62320	CSC1-like protein At1g62320	Arabidopsis thaliana (Mouse-ear cress)	PR
Q5XEZ5	CSC1	Calcium permeable stress-gated cation channel 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94A87	At1g10090	CSC1-like protein At1g10090	Arabidopsis thaliana (Mouse-ear cress)	PR
F4IBD7	RXW8	CSC1-like protein RXW8	Arabidopsis thaliana (Mouse-ear cress)	PR