Q5XEZ5

PR
Gene name
CSC1
Protein name
Calcium permeable stress-gated cation channel 1
Names
AtCSC1, Hyperosmolality-gated Ca2+ permeable channel 1.2, AtOSCA1.2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G22120
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-87 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q5XEZ5

Entry ID Method Resolution Chain Position Source
6IJZ EM 368 A A/B 1-771 PDB
6MGV EM 310 A A/B 1-771 PDB
6MGW EM 350 A A/B 1-771 PDB
8T56 EM 280 A A/B 1-771 PDB
AF-Q5XEZ5-F1 Predicted AlphaFoldDB

39 variants for Q5XEZ5

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_4_11719104_T_C 14 N>S No 1000Genomes
ENSVATH06749961 20 V>I No 1000Genomes
ENSVATH14277706 40 S>L No 1000Genomes
tmp_4_11718990_G_C 52 A>G No 1000Genomes
ENSVATH00530286 58 A>G No 1000Genomes
tmp_4_11718903_T_C 81 K>R No 1000Genomes
ENSVATH12134642 128 N>K No 1000Genomes
tmp_4_11718499_G_A 141 S>L No 1000Genomes
ENSVATH06749957 148 S>C No 1000Genomes
ENSVATH00530280 149 V>I No 1000Genomes
ENSVATH14277684 164 V>L No 1000Genomes
tmp_4_11718314_T_A 171 I>F No 1000Genomes
tmp_4_11717876_T_G 254 K>Q No 1000Genomes
tmp_4_11717826_G_T 270 N>K No 1000Genomes
ENSVATH12134639 341 Q>* No 1000Genomes
tmp_4_11717503_C_T 351 E>K No 1000Genomes
ENSVATH12134638 380 V>I No 1000Genomes
ENSVATH06749945 391 V>I No 1000Genomes
ENSVATH14277680 455 T>I No 1000Genomes
ENSVATH12134635 467 R>Q No 1000Genomes
ENSVATH06749938 476 V>L No 1000Genomes
tmp_4_11716991_T_C 491 N>S No 1000Genomes
tmp_4_11716973_G_A 497 S>F No 1000Genomes
ENSVATH14277679 541 F>C No 1000Genomes
ENSVATH14277678 546 A>T No 1000Genomes
ENSVATH06749934 557 E>K No 1000Genomes
ENSVATH12134573 563 S>C No 1000Genomes
tmp_4_11716765_A_T 566 F>L No 1000Genomes
tmp_4_11716653_C_T 604 V>I No 1000Genomes
tmp_4_11716517_A_T 623 F>Y No 1000Genomes
tmp_4_11716356_C_T 677 E>K No 1000Genomes
ENSVATH02906045 696 T>S No 1000Genomes
ENSVATH06749927 704 L>F No 1000Genomes
ENSVATH12134565 705 K>N No 1000Genomes
ENSVATH00530268 706 G>S No 1000Genomes
tmp_4_11716121_T_G 724 Y>S No 1000Genomes
tmp_4_11716086_C_T 736 E>K No 1000Genomes
ENSVATH00530263 759 D>E No 1000Genomes
tmp_4_11716001_A_T 764 L>* No 1000Genomes

No associated diseases with Q5XEZ5

3 regional properties for Q5XEZ5

Type Name Position InterPro Accession
domain CSC1/OSCA1-like, 7TM region 374 - 646 IPR003864
domain CSC1/OSCA1-like, cytosolic domain 201 - 363 IPR027815
domain CSC1/OSCA1-like, N-terminal transmembrane domain 7 - 180 IPR032880

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
calcium activated cation channel activity Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.
identical protein binding Binding to an identical protein or proteins.
mechanosensitive ion channel activity Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.

1 GO annotations of biological process

Name Definition
cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5T3F8 TMEM63B CSC1-like protein 2 Homo sapiens (Human) PR
Q9P1W3 TMEM63C Calcium permeable stress-gated cation channel 1 Homo sapiens (Human) PR
O94886 TMEM63A CSC1-like protein 1 Homo sapiens (Human) PR
Q91YT8 Tmem63a CSC1-like protein 1 Mus musculus (Mouse) PR
B5TYT3 At1g11960 CSC1-like protein At1g11960 Arabidopsis thaliana (Mouse-ear cress) PR
F4HYR3 At1g62320 CSC1-like protein At1g62320 Arabidopsis thaliana (Mouse-ear cress) PR
Q94A87 At1g10090 CSC1-like protein At1g10090 Arabidopsis thaliana (Mouse-ear cress) PR
Q9XEA1 OSCA1 Protein OSCA1 Arabidopsis thaliana (Mouse-ear cress) PR
F4IBD7 RXW8 CSC1-like protein RXW8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MATLQDIGVS AGINILSAFV FFIIFAVLRL QPFNDRVYFS KWYLKGLRSS PARGGAFAQR
70 80 90 100 110 120
FVNLDFRSYM KFLNWMPEAL KMPEPELIDH AGLDSVVYLR IYWLGLKIFT PIAVLAWAVL
130 140 150 160 170 180
VPVNWTNNTL EMAKQLRNVT SSDIDKLSVS NIPEYSMRFW THIVMAYAFT IWTCYVLMKE
190 200 210 220 230 240
YETIANMRLQ FVASEARRPD QFTVLVRNVP PDADESVSEL VEHFFLVNHP DHYLTHQVVC
250 260 270 280 290 300
NANKLADLVK KKKKLQNWLD YYQLKYARNN SQRIMVKLGF LGLWGQKVDA IEHYIAEIDK
310 320 330 340 350 360
ISKEISKERE EVVNDPKAIM PAAFVSFKTR WAAAVCAQTQ QTRNPTQWLT EWAPEPRDVF
370 380 390 400 410 420
WSNLAIPYVS LTVRRLIMHV AFFFLTFFFI VPIAFVQSLA TIEGIVKAAP FLKFIVDDKF
430 440 450 460 470 480
MKSVIQGFLP GIALKLFLAF LPSILMIMSK FEGFTSISSL ERRAAFRYYI FNLVNVFLAS
490 500 510 520 530 540
VIAGAAFEQL NSFLNQSANQ IPKTIGVAIP MKATFFITYI MVDGWAGVAG EILMLKPLIM
550 560 570 580 590 600
FHLKNAFLVK TDKDREEAMD PGSIGFNTGE PRIQLYFLLG LVYAPVTPML LPFILVFFAL
610 620 630 640 650 660
AYIVYRHQII NVYNQEYESA AAFWPDVHGR VIAALVISQL LLMGLLGTKH AALAAPFLIA
670 680 690 700 710 720
LPVLTIGFHH FCKGRYEPAF IRYPLQEAMM KDTLETAREP NLNLKGYLQN AYVHPVFKGD
730 740 750 760 770
EDDYDIDDKL GKFEDEAIIV PTKRQSRRNT PAPSIISGDD SPSLPFSGKL V