Q91YT8
Gene name |
Tmem63a (Kiaa0792) |
Protein name |
CSC1-like protein 1 |
Names |
Transmembrane protein 63A |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:208795 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91YT8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91YT8-F1 | Predicted | AlphaFoldDB |
39 variants for Q91YT8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs32737187 | 18 | R>H | No | EVA | |
| rs3388516150 | 34 | N>Y | No | EVA | |
| rs3388523040 | 42 | L>F | No | EVA | |
| rs3391069282 | 47 | F>L | No | EVA | |
| rs3388522142 | 52 | T>S | No | EVA | |
| rs3388522883 | 109 | E>D | No | EVA | |
| rs3388519735 | 153 | S>C | No | EVA | |
| rs3388522114 | 173 | D>E | No | EVA | |
| rs3388522024 | 184 | N>K | No | EVA | |
| rs3388516513 | 235 | P>H | No | EVA | |
| rs3388516480 | 242 | T>S | No | EVA | |
| rs3388516473 | 247 | F>L | No | EVA | |
| rs224033894 | 248 | R>Q | No | EVA | |
| rs3388523043 | 305 | Q>L | No | EVA | |
| rs3388520276 | 334 | I>N | No | EVA | |
| rs240542123 | 354 | R>C | No | EVA | |
| rs32737691 | 361 | Y>H | No | EVA | |
| rs3388516066 | 398 | F>I | No | EVA | |
| rs3388516066 | 398 | F>L | No | EVA | |
| rs3388523053 | 417 | W>R | No | EVA | |
| rs3388522121 | 449 | N>I | No | EVA | |
| rs3388522839 | 461 | V>I | No | EVA | |
| rs3388522858 | 469 | L>F | No | EVA | |
| rs3388522018 | 481 | I>T | No | EVA | |
| rs3388524305 | 488 | L>P | No | EVA | |
| rs265463243 | 512 | M>T | No | EVA | |
| rs3388520392 | 581 | T>I | No | EVA | |
| rs3388519817 | 585 | I>T | No | EVA | |
| rs3388521791 | 611 | A>T | No | EVA | |
| rs3388518468 | 620 | I>F | No | EVA | |
| rs3388521848 | 666 | A>V | No | EVA | |
| rs3388521818 | 687 | L>V | No | EVA | |
| rs3388523406 | 688 | R>S | No | EVA | |
| rs3388516461 | 753 | P>S | No | EVA | |
| rs3388524317 | 769 | Q>* | No | EVA | |
| rs3388518291 | 772 | Q>* | No | EVA | |
| rs3412880412 | 778 | R>H | No | EVA | |
| rs3388522007 | 794 | S>N | No | EVA | |
| rs239194651 | 795 | G>D | No | EVA |
No associated diseases with Q91YT8
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| centriolar satellite | A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium activated cation channel activity | Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. |
| mechanosensitive ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress. |
| nucleic acid binding | Binding to a nucleic acid. |
| osmolarity-sensing cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5T3F8 | TMEM63B | CSC1-like protein 2 | Homo sapiens (Human) | PR |
| Q9P1W3 | TMEM63C | Calcium permeable stress-gated cation channel 1 | Homo sapiens (Human) | PR |
| O94886 | TMEM63A | CSC1-like protein 1 | Homo sapiens (Human) | PR |
| Q94A87 | At1g10090 | CSC1-like protein At1g10090 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B5TYT3 | At1g11960 | CSC1-like protein At1g11960 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4IBD7 | RXW8 | CSC1-like protein RXW8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4HYR3 | At1g62320 | CSC1-like protein At1g62320 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9XEA1 | OSCA1 | Protein OSCA1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5XEZ5 | CSC1 | Calcium permeable stress-gated cation channel 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSSPFLDPW | PSKAVFVRER | LGLGERPNDS | YCYNSAKNST | VLQGVTFGGI | PTVLLLDVSC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLFLILVFSI | IRRRFWDYGR | IALVSEAGSE | ARFQRLSSSS | SGQQDFENEL | GCCPWLTAIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLHDDQILEW | CGEDAIHYLS | FQRHIIFLLV | VISFLSLCVI | LPVNLSGDLL | GKDPYSFGRT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TIANLQTDND | LLWLHTVFSV | IYLFLTVGFM | WHHTRSIRYK | EESLVRQTLF | ITGLPREARK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ETVESHFRDA | YPTCEVVDVQ | LCYSVAKLIY | LCKERKKTEK | SLTYYTNLQA | KTGRRTLINP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPCGQFCCCE | VQGCEREDAI | SYYTRMNDSL | LERITAEESR | VQDQPLGMAF | VTFREKSMAT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YILKDFNACK | CQGLRCKGEP | QPSSYSRELC | VSKWTVTFAS | YPEDICWKNL | SIQGVRWWLQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WLGINFSLFV | VLFFLTTPSI | IMSTMDKFNV | TKPIHALNNP | VISQFFPTLL | LWSFSALLPS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IVYYSTLLES | HWTRSGENRI | MVSKVYIFLI | FMVLILPSLG | LTSLDFFFRW | LFDKTSSETS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IRLECVFLPD | QGAFFVNYVI | ASAFIGSGME | LLRLPGLILY | TFRMIMAKTA | ADRRNVKQNQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AFEYEFGAMY | AWMLCVFTVI | MAYSITCPII | VPFGLIYILL | KHMVDRHNLY | FAYLPAKLEK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RIHFAAVNQA | LAAPILCLFW | LFFFSFLRLG | LTAPATLFTF | LVVLLTILAC | LLYTCFGCFK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HLSPWNYKTE | ESASDKGSEA | EAHVPPPFTP | YVPRILNGLA | SERTALSPQQ | QQTYGAIRNI |
| 790 | 800 | ||||
| SGTLPGQPVA | QDPSGTAAYA | YQES |