AiPD: Autoinhibited Protein Database

Gene name	At1g11960 (F12F1.17)
Protein name	CSC1-like protein At1g11960
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G11960
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

19-88 (Predicted disordered autoinhibitory region) PR

19-88 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-B5TYT3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_1_4043095_T_C	17	T>A	No	1000Genomes
ENSVATH04561600	19	I>T	No	1000Genomes
tmp_1_4042974_A_C	57	L>R	No	1000Genomes
ENSVATH00018848	77	P>S	No	1000Genomes
tmp_1_4042047_G_A	258	L>F	No	1000Genomes
ENSVATH13882768	265	Y>H	No	1000Genomes
ENSVATH11018084	271	H>Q	No	1000Genomes
tmp_1_4041862_G_T	292	H>N	No	1000Genomes
tmp_1_4041844_C_G	298	E>Q	No	1000Genomes
tmp_1_4041838_A_T	300	L>I	No	1000Genomes
ENSVATH01038653	305	M>L	No	1000Genomes
ENSVATH04561588	308	R>K	No	1000Genomes
ENSVATH04561587	333	A>V	No	1000Genomes
ENSVATH00018845	335	S>C	No	1000Genomes
ENSVATH01038651	361	S>P	No	1000Genomes
ENSVATH04561585	365	I>V	No	1000Genomes
tmp_1_4041527_A_G	377	M>T	No	1000Genomes
tmp_1_4041167_T_A	471	N>Y	No	1000Genomes
ENSVATH04561581	490	D>N	No	1000Genomes
ENSVATH01038648	517	T>S	No	1000Genomes
tmp_1_4040913_T_C	527	I>V	No	1000Genomes
tmp_1_4040823_C_T	557	A>T	No	1000Genomes
tmp_1_4040673_G_C	607	Q>E	No	1000Genomes
ENSVATH11018079	626	V>A	No	1000Genomes
tmp_1_4040427_A_C	632	S>A	No	1000Genomes
ENSVATH04561570	651	A>V	No	1000Genomes
ENSVATH00018840	674	R>W	No	1000Genomes
ENSVATH00018839	679	F>L	No	1000Genomes
ENSVATH04561566	704	K>R	No	1000Genomes
tmp_1_4040061_T_C	709	K>R	No	1000Genomes
tmp_1_4040030_G_T	719	N>K	No	1000Genomes
ENSVATH11018077	732	Y>S	No	1000Genomes
tmp_1_4039975_C_G	738	D>H	No	1000Genomes
tmp_1_4039944_C_T	748	R>H	No	1000Genomes
ENSVATH04561565	749	Q>R	No	1000Genomes
ENSVATH04561564	753	N>I	No	1000Genomes
ENSVATH00018835	762	R>H	No	1000Genomes
ENSVATH00018834	766	R>C	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	CSC1/OSCA1-like, 7TM region	373 - 645	IPR003864
domain	CSC1/OSCA1-like, cytosolic domain	200 - 362	IPR027815
domain	CSC1/OSCA1-like, N-terminal transmembrane domain	7 - 179	IPR032880

		Description
EC Number
Subcellular Localization	Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
calcium activated cation channel activity	Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.
calcium channel activity	Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

Name	Definition
PAMP-triggered immunity signalling pathway	The series of molecular signals initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
stomatal movement	The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata).

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5T3F8	TMEM63B	CSC1-like protein 2	Homo sapiens (Human)	PR
Q9P1W3	TMEM63C	Calcium permeable stress-gated cation channel 1	Homo sapiens (Human)	PR
O94886	TMEM63A	CSC1-like protein 1	Homo sapiens (Human)	PR
Q91YT8	Tmem63a	CSC1-like protein 1	Mus musculus (Mouse)	PR
F4HYR3	At1g62320	CSC1-like protein At1g62320	Arabidopsis thaliana (Mouse-ear cress)	PR
Q5XEZ5	CSC1	Calcium permeable stress-gated cation channel 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94A87	At1g10090	CSC1-like protein At1g10090	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9XEA1	OSCA1	Protein OSCA1	Arabidopsis thaliana (Mouse-ear cress)	PR
F4IBD7	RXW8	CSC1-like protein RXW8	Arabidopsis thaliana (Mouse-ear cress)	PR