Q9SD76
PR
Gene name |
PHS2 (At3g46970, F13I12.20) |
Protein name |
Alpha-glucan phosphorylase 2, cytosolic |
Names |
AtPHS2, Alpha-glucan phosphorylase, H isozyme, Starch phosphorylase H |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G46970 |
EC number |
2.4.1.1: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q9SD76
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4BQE | X-ray | 170 A | A/B | 1-841 | PDB |
| 4BQF | X-ray | 235 A | A/B | 1-841 | PDB |
| 4BQI | X-ray | 190 A | A/B | 1-841 | PDB |
| AF-Q9SD76-F1 | Predicted | AlphaFoldDB |
63 variants for Q9SD76
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_17306108_C_T | 2 | A>T | No | 1000Genomes | |
| ENSVATH00404386 | 6 | G>R | No | 1000Genomes | |
| ENSVATH12590411 | 12 | L>I | No | 1000Genomes | |
| ENSVATH00404385 | 13 | P>L | No | 1000Genomes | |
| ENSVATH12590410 | 20 | A>V | No | 1000Genomes | |
| tmp_3_17306025_C_A | 29 | E>D | No | 1000Genomes | |
| ENSVATH00404384 | 47 | L>S | No | 1000Genomes | |
| tmp_3_17305940_T_A | 58 | T>S | No | 1000Genomes | |
| ENSVATH12590408 | 62 | L>F | No | 1000Genomes | |
| tmp_3_17305916_G_A | 66 | L>F | No | 1000Genomes | |
| tmp_3_17305553_T_A | 125 | I>L | No | 1000Genomes | |
| tmp_3_17305349_C_T | 165 | R>K | No | 1000Genomes | |
| tmp_3_17305318_C_A | 175 | K>N | No | 1000Genomes | |
| tmp_3_17305164_A_C | 200 | V>G | No | 1000Genomes | |
| tmp_3_17304894_T_A | 239 | T>S | No | 1000Genomes | |
| ENSVATH06254479 | 244 | S>N | No | 1000Genomes | |
| ENSVATH00404380 | 273 | L>F | No | 1000Genomes | |
| ENSVATH02457079 | 282 | T>I | No | 1000Genomes | |
| ENSVATH02457078 | 292 | N>S | No | 1000Genomes | |
| ENSVATH12590354 | 298 | L>V | No | 1000Genomes | |
| tmp_3_17304326_A_G | 313 | I>T | No | 1000Genomes | |
| tmp_3_17304320_C_A | 315 | R>I | No | 1000Genomes | |
| ENSVATH02457072 | 316 | F>Y | No | 1000Genomes | |
| ENSVATH12590348 | 317 | H>R | No | 1000Genomes | |
| ENSVATH06254462 | 322 | T>I | No | 1000Genomes | |
| ENSVATH02457071 | 322 | T>P | No | 1000Genomes | |
| ENSVATH06254461 | 325 | S>N | No | 1000Genomes | |
| tmp_3_17304278_G_A | 329 | S>L | No | 1000Genomes | |
| tmp_3_17304267_T_C | 333 | S>G | No | 1000Genomes | |
| ENSVATH14388051 | 360 | G>R | No | 1000Genomes | |
| tmp_3_17304005_A_G | 392 | S>P | No | 1000Genomes | |
| tmp_3_17303863_G_C | 415 | T>S | No | 1000Genomes | |
| ENSVATH14388050 | 417 | R>C | No | 1000Genomes | |
| tmp_3_17303842_T_A | 422 | D>V | No | 1000Genomes | |
| tmp_3_17303814_G_T | 431 | S>R | No | 1000Genomes | |
| tmp_3_17303794_T_G | 438 | Q>P | No | 1000Genomes | |
| tmp_3_17303790_C_T,G | 439 | K>N | No | 1000Genomes | |
| ENSVATH00404368 | 518 | D>H | No | 1000Genomes | |
| tmp_3_17303460_C_G | 520 | D>H | No | 1000Genomes | |
| tmp_3_17303439_G_C | 527 | Q>E | No | 1000Genomes | |
| tmp_3_17303342_C_T | 532 | E>K | No | 1000Genomes | |
| ENSVATH06254436 | 544 | A>T | No | 1000Genomes | |
| ENSVATH14388049 | 547 | K>E | No | 1000Genomes | |
| ENSVATH06254425 | 601 | E>D | No | 1000Genomes | |
| ENSVATH06254421 | 636 | V>I | No | 1000Genomes | |
| ENSVATH06254400 | 650 | V>I | No | 1000Genomes | |
| ENSVATH14388040 | 658 | T>S | No | 1000Genomes | |
| ENSVATH14388039 | 689 | A>T | No | 1000Genomes | |
| tmp_3_17302337_T_C | 696 | I>V | No | 1000Genomes | |
| ENSVATH14388037 | 712 | E>K | No | 1000Genomes | |
| tmp_3_17302246_G_A | 726 | P>L | No | 1000Genomes | |
| ENSVATH12590242 | 727 | R>Q | No | 1000Genomes | |
| tmp_3_17302046_G_A | 742 | R>W | No | 1000Genomes | |
| ENSVATH06254390 | 759 | D>A | No | 1000Genomes | |
| tmp_3_17301985_G_A | 762 | P>L | No | 1000Genomes | |
| tmp_3_17301980_G_C | 764 | L>V | No | 1000Genomes | |
| tmp_3_17301966_C_G | 768 | E>D | No | 1000Genomes | |
| ENSVATH12590204 | 771 | T>R | No | 1000Genomes | |
| ENSVATH06254387 | 797 | E>V | No | 1000Genomes | |
| ENSVATH06254383 | 802 | R>Q | No | 1000Genomes | |
| tmp_3_17301731_T_C | 807 | K>R | No | 1000Genomes | |
| ENSVATH14388035 | 824 | T>S | No | 1000Genomes | |
| ENSVATH00404353 | 834 | N>K | No | 1000Genomes |
No associated diseases with Q9SD76
1 regional properties for Q9SD76
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Phosphorylase pyridoxal-phosphate attachment site | 679 - 691 | IPR035090 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.1 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1,4-alpha-oligoglucan phosphorylase activity | Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. |
| glycogen phosphorylase activity | Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. |
| linear malto-oligosaccharide phosphorylase activity | Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| SHG alpha-glucan phosphorylase activity | Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glycogen catabolic process | The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. |
| response to water deprivation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P06738 | GPH1 | Glycogen phosphorylase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q0VCM4 | PYGL | Glycogen phosphorylase, liver form | Bos taurus (Bovine) | PR |
| P11216 | PYGB | Glycogen phosphorylase, brain form | Homo sapiens (Human) | PR |
| P06737 | PYGL | Glycogen phosphorylase, liver form | Homo sapiens (Human) | PR |
| P11217 | PYGM | Glycogen phosphorylase, muscle form | Homo sapiens (Human) | PR |
| Q8CI94 | Pygb | Glycogen phosphorylase, brain form | Mus musculus (Mouse) | PR |
| Q9ET01 | Pygl | Glycogen phosphorylase, liver form | Mus musculus (Mouse) | PR |
| Q9WUB3 | Pygm | Glycogen phosphorylase, muscle form | Mus musculus (Mouse) | PR |
| P04045 | Alpha-1,4 glucan phosphorylase L-1 isozyme, chloroplastic/amyloplastic | Solanum tuberosum (Potato) | PR | |
| P53535 | STP-1 | Alpha-1,4 glucan phosphorylase L-2 isozyme, chloroplastic/amyloplastic | Solanum tuberosum (Potato) | PR |
| P32811 | Alpha-glucan phosphorylase, H isozyme | Solanum tuberosum (Potato) | PR | |
| P09811 | Pygl | Glycogen phosphorylase, liver form | Rattus norvegicus (Rat) | PR |
| P09812 | Pygm | Glycogen phosphorylase, muscle form | Rattus norvegicus (Rat) | PR |
| Q9LIB2 | PHS1 | Alpha-glucan phosphorylase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANANGKAAT | SLPEKISAKA | NPEADDATEI | AGNIVYHAKY | SPHFSPLKFG | PEQALYATAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLRDRLIQLW | NETYVHFNKV | DPKQTYYLSM | EYLQGRALTN | AIGNLNLQGP | YADALRTLGY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELEEIAEQEK | DAALGNGGLG | RLASCFLDSM | ATLNLPAWGY | GLRYRHGLFK | QIITKKGQEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IPEDWLEKFS | PWEIVRHDVV | FPVRFFGKVQ | VNPDGSRKWV | DGDVVQALAY | DVPIPGYGTK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NTISLRLWEA | KARAEDLDLF | QFNEGEYELA | AQLHSRAQQI | CTVLYPGDAT | ENGKLLRLKQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QFFLCSASLQ | DIISRFHERS | TTEGSRKWSE | FPSKVAVQMN | DTHPTLAIPE | LMRLLMDDNG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGWDEAWDVT | SKTVAYTNHT | VLPEALEKWS | QSLMWKLLPR | HMEIIEEIDK | RFVQTIRDTR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VDLEDKISSL | SILDNNPQKP | VVRMANLCVV | SSHTVNGVAQ | LHSDILKAEL | FADYVSIWPN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KFQNKTNGIT | PRRWLRFCSP | ELSDIITKWL | KTDKWITDLD | LLTGLRQFAD | NEELQSEWAS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AKTANKKRLA | QYIERVTGVS | IDPTSLFDIQ | VKRIHEYKRQ | LMNILGVVYR | FKKLKEMKPE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ERKKTVPRTV | MIGGKAFATY | TNAKRIVKLV | NDVGDVVNSD | PEVNEYLKVV | FVPNYNVTVA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EMLIPGSELS | QHISTAGMEA | SGTSNMKFAL | NGCLIIGTLD | GANVEIREEV | GEENFFLFGA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TADQVPRLRK | EREDGLFKPD | PRFEEAKQFV | KSGVFGSYDY | GPLLDSLEGN | TGFGRGDYFL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VGYDFPSYMD | AQAKVDEAYK | DRKGWLKMSI | LSTAGSGKFS | SDRTIAQYAK | EIWNIEACPV |
| P |