Q9LIB2
PR
Gene name |
PHS1 (At3g29320, MUO10.17) |
Protein name |
Alpha-glucan phosphorylase 1 |
Names |
AtPHS1, Alpha-glucan phosphorylase, L isozyme, Starch phosphorylase L |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G29320 |
EC number |
2.4.1.1: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LIB2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LIB2-F1 | Predicted | AlphaFoldDB |
127 variants for Q9LIB2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05976511 | 4 | M>L | No | 1000Genomes | |
| tmp_3_11252887_T_C | 6 | I>T | No | 1000Genomes | |
| ENSVATH11230704 | 9 | V>E | No | 1000Genomes | |
| tmp_3_11252901_A_T | 11 | T>S | No | 1000Genomes | |
| ENSVATH00364179 | 12 | G>R | No | 1000Genomes | |
| ENSVATH02253493 | 14 | E>D | No | 1000Genomes | |
| ENSVATH02253494 | 15 | V>I | No | 1000Genomes | |
| tmp_3_11252918_A_T | 16 | L>F | No | 1000Genomes | |
| ENSVATH11230755 | 17 | I>T | No | 1000Genomes | |
| ENSVATH11230756 | 21 | S>C | No | 1000Genomes | |
| tmp_3_11252947_T_A | 26 | V>D | No | 1000Genomes | |
| ENSVATH11230757 | 32 | D>E | No | 1000Genomes | |
| ENSVATH02253495 | 34 | K>Q | No | 1000Genomes | |
| ENSVATH02253496 | 34 | K>R | No | 1000Genomes | |
| ENSVATH05976514 | 35 | W>L | No | 1000Genomes | |
| ENSVATH05976515 | 37 | T>M | No | 1000Genomes | |
| ENSVATH05976517 | 45 | R>G | No | 1000Genomes | |
| tmp_3_11253004_G_A | 45 | R>K | No | 1000Genomes | |
| ENSVATH00364180 | 46 | D>N | No | 1000Genomes | |
| tmp_3_11253011_G_C | 47 | L>F | No | 1000Genomes | |
| ENSVATH02253499 | 49 | P>T | No | 1000Genomes | |
| ENSVATH02253500 | 57 | L>F | No | 1000Genomes | |
| tmp_3_11253051_T_G | 61 | S>A | No | 1000Genomes | |
| ENSVATH02253501 | 62 | I>V | No | 1000Genomes | |
| ENSVATH00364181 | 68 | A>S | No | 1000Genomes | |
| ENSVATH14076835 | 69 | K>R | No | 1000Genomes | |
| ENSVATH02253504 | 70 | V>A | No | 1000Genomes | |
| ENSVATH00364183 | 94 | A>D | No | 1000Genomes | |
| ENSVATH02253509 | 121 | F>Y | No | 1000Genomes | |
| ENSVATH05976527 | 126 | Q>L | No | 1000Genomes | |
| ENSVATH05976528 | 145 | R>K | No | 1000Genomes | |
| ENSVATH11230764 | 147 | N>D | No | 1000Genomes | |
| tmp_3_11253444_A_T | 150 | Q>H | No | 1000Genomes | |
| ENSVATH00364190 | 175 | S>N | No | 1000Genomes | |
| ENSVATH05976529 | 192 | A>T | No | 1000Genomes | |
| ENSVATH05976530 | 218 | T>S | No | 1000Genomes | |
| tmp_3_11253940_T_G | 239 | I>M | No | 1000Genomes | |
| tmp_3_11254171_T_C | 276 | V>A | No | 1000Genomes | |
| tmp_3_11254179_T_A | 279 | S>T | No | 1000Genomes | |
| tmp_3_11254189_A_G | 282 | K>R | No | 1000Genomes | |
| ENSVATH05976537 | 292 | V>A | No | 1000Genomes | |
| ENSVATH00364194 | 294 | V>I | No | 1000Genomes | |
| tmp_3_11254294_A_G | 317 | K>R | No | 1000Genomes | |
| ENSVATH05976543 | 333 | H>Q | No | 1000Genomes | |
| tmp_3_11254359_G_T | 339 | A>S | No | 1000Genomes | |
| ENSVATH00364198 | 357 | T>A | No | 1000Genomes | |
| ENSVATH02253542 | 361 | A>S | No | 1000Genomes | |
| ENSVATH00364200 | 379 | V>I | No | 1000Genomes | |
| ENSVATH11230819 | 383 | E>G | No | 1000Genomes | |
| ENSVATH05976552 | 388 | G>E | No | 1000Genomes | |
| tmp_3_11254760_G_A | 388 | G>R | No | 1000Genomes | |
| tmp_3_11254824_C_T | 409 | T>I | No | 1000Genomes | |
| tmp_3_11254844_A_T | 416 | M>L | No | 1000Genomes | |
| ENSVATH14076865 | 424 | G>R | No | 1000Genomes | |
| tmp_3_11255113_G_A | 456 | E>K | No | 1000Genomes | |
| tmp_3_11255137_C_T | 464 | R>C | No | 1000Genomes | |
| ENSVATH05976558 | 466 | V>E | No | 1000Genomes | |
| ENSVATH05976559 | 474 | E>D | No | 1000Genomes | |
| ENSVATH05976560 | 478 | R>C | No | 1000Genomes | |
| ENSVATH05976560 | 478 | R>S | No | 1000Genomes | |
| ENSVATH05976561 | 484 | Y>F | No | 1000Genomes | |
| tmp_3_11255281_A_T | 486 | T>S | No | 1000Genomes | |
| ENSVATH00364208 | 487 | A>V | No | 1000Genomes | |
| ENSVATH02253562 | 494 | E>* | No | 1000Genomes | |
| ENSVATH00364209 | 494 | E>A | No | 1000Genomes | |
| tmp_3_11255343_G_C | 506 | E>D | No | 1000Genomes | |
| tmp_3_11255371_G_T | 516 | V>L | No | 1000Genomes | |
| ENSVATH11230875 | 521 | K>N | No | 1000Genomes | |
| ENSVATH11230876 | 522 | P>S | No | 1000Genomes | |
| ENSVATH14076869 | 526 | K>R | No | 1000Genomes | |
| tmp_3_11255408_C_T | 528 | A>V | No | 1000Genomes | |
| tmp_3_11255415_T_G | 530 | N>K | No | 1000Genomes | |
| ENSVATH00364210 | 534 | T>A | No | 1000Genomes | |
| tmp_3_11255438_A_T | 538 | E>V | No | 1000Genomes | |
| tmp_3_11255444_A_G | 540 | K>R | No | 1000Genomes | |
| ENSVATH05976563 | 543 | G>R | No | 1000Genomes | |
| ENSVATH05976564 | 547 | E>D | No | 1000Genomes | |
| ENSVATH05976565 | 548 | D>A | No | 1000Genomes | |
| ENSVATH02253566 | 548 | D>E | No | 1000Genomes | |
| ENSVATH11230878 | 554 | P>R | No | 1000Genomes | |
| tmp_3_11255485_C_A | 554 | P>T | No | 1000Genomes | |
| ENSVATH05976566 | 557 | E>K | No | 1000Genomes | |
| ENSVATH02253567 | 558 | P>L | No | 1000Genomes | |
| ENSVATH05976567 | 558 | P>T | No | 1000Genomes | |
| tmp_3_11255516_T_C | 564 | M>T | No | 1000Genomes | |
| ENSVATH02253569 | 570 | V>A | No | 1000Genomes | |
| ENSVATH05976570 | 571 | G>A | No | 1000Genomes | |
| tmp_3_11255575_G_A | 584 | E>K | No | 1000Genomes | |
| tmp_3_11255589_G_C | 588 | Q>H | No | 1000Genomes | |
| tmp_3_11255601_T_A | 592 | N>K | No | 1000Genomes | |
| ENSVATH05976573 | 625 | I>V | No | 1000Genomes | |
| ENSVATH02253575 | 632 | T>A | No | 1000Genomes | |
| tmp_3_11255819_C_G | 634 | D>E | No | 1000Genomes | |
| ENSVATH05976574 | 640 | E>A | No | 1000Genomes | |
| ENSVATH11230880 | 640 | E>K | No | 1000Genomes | |
| ENSVATH00364214 | 642 | V>L | No | 1000Genomes | |
| ENSVATH05976575 | 643 | A>G | No | 1000Genomes | |
| ENSVATH05976576 | 644 | E>Q | No | 1000Genomes | |
| tmp_3_11255956_A_T | 651 | N>I | No | 1000Genomes | |
| ENSVATH00364217 | 655 | Q>R | No | 1000Genomes | |
| ENSVATH05976579 | 663 | K>R | No | 1000Genomes | |
| ENSVATH05976581 | 667 | L>W | No | 1000Genomes | |
| tmp_3_11256023_C_G | 673 | I>M | No | 1000Genomes | |
| ENSVATH11230881 | 684 | D>N | No | 1000Genomes | |
| tmp_3_11256259_T_G | 707 | I>S | No | 1000Genomes | |
| ENSVATH00364223 | 709 | Y>H | No | 1000Genomes | |
| ENSVATH05976592 | 712 | K>R | No | 1000Genomes | |
| tmp_3_11256277_A_C | 713 | K>T | No | 1000Genomes | |
| ENSVATH05976594 | 727 | V>A | No | 1000Genomes | |
| tmp_3_11256429_A_C | 764 | I>L | No | 1000Genomes | |
| tmp_3_11256581_A_G | 771 | I>V | No | 1000Genomes | |
| tmp_3_11256978_G_T | 825 | V>F | No | 1000Genomes | |
| ENSVATH00364232 | 845 | Q>E | No | 1000Genomes | |
| ENSVATH02253586 | 872 | G>R | No | 1000Genomes | |
| ENSVATH11231020 | 875 | V>I | No | 1000Genomes | |
| ENSVATH05976631 | 877 | G>S | No | 1000Genomes | |
| ENSVATH02253587 | 880 | S>N | No | 1000Genomes | |
| ENSVATH05976633 | 886 | G>A | No | 1000Genomes | |
| ENSVATH05976632 | 886 | G>R | No | 1000Genomes | |
| ENSVATH11231021 | 896 | R>Q | No | 1000Genomes | |
| ENSVATH14076926 | 904 | K>E | No | 1000Genomes | |
| tmp_3_11257335_A_G | 914 | E>G | No | 1000Genomes | |
| tmp_3_11257338_A_G | 915 | K>R | No | 1000Genomes | |
| ENSVATH05976634 | 921 | R>L | No | 1000Genomes | |
| ENSVATH05976634 | 921 | R>Q | No | 1000Genomes | |
| tmp_3_11257540_G_C | 948 | E>Q | No | 1000Genomes | |
| ENSVATH02253591 | 959 | V>M | No | 1000Genomes |
No associated diseases with Q9LIB2
1 regional properties for Q9LIB2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Phosphorylase pyridoxal-phosphate attachment site | 800 - 812 | IPR035090 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.1 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plastid | Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1,4-alpha-oligoglucan phosphorylase activity | Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. |
| glycogen phosphorylase activity | Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. |
| linear malto-oligosaccharide phosphorylase activity | Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| SHG alpha-glucan phosphorylase activity | Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| glycogen catabolic process | The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. |
| response to temperature stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. |
| response to water deprivation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P06738 | GPH1 | Glycogen phosphorylase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q0VCM4 | PYGL | Glycogen phosphorylase, liver form | Bos taurus (Bovine) | PR |
| P11216 | PYGB | Glycogen phosphorylase, brain form | Homo sapiens (Human) | PR |
| P06737 | PYGL | Glycogen phosphorylase, liver form | Homo sapiens (Human) | PR |
| P11217 | PYGM | Glycogen phosphorylase, muscle form | Homo sapiens (Human) | PR |
| Q8CI94 | Pygb | Glycogen phosphorylase, brain form | Mus musculus (Mouse) | PR |
| Q9ET01 | Pygl | Glycogen phosphorylase, liver form | Mus musculus (Mouse) | PR |
| Q9WUB3 | Pygm | Glycogen phosphorylase, muscle form | Mus musculus (Mouse) | PR |
| P04045 | Alpha-1,4 glucan phosphorylase L-1 isozyme, chloroplastic/amyloplastic | Solanum tuberosum (Potato) | PR | |
| P53535 | STP-1 | Alpha-1,4 glucan phosphorylase L-2 isozyme, chloroplastic/amyloplastic | Solanum tuberosum (Potato) | PR |
| P09811 | Pygl | Glycogen phosphorylase, liver form | Rattus norvegicus (Rat) | PR |
| P09812 | Pygm | Glycogen phosphorylase, muscle form | Rattus norvegicus (Rat) | PR |
| Q9SD76 | PHS2 | Alpha-glucan phosphorylase 2, cytosolic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDTMRISGVS | TGAEVLIQCN | SLSSLVSRRC | DDGKWRTRMF | PARNRDLRPS | PTRRSFLSVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SISSEPKAKV | TDAVLDSEQE | VFISSMNPFA | PDAASVASSI | KYHAEFTPLF | SPEKFELPKA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FFATAQSVRD | ALIMNWNATY | EYYNRVNVKQ | AYYLSMEFLQ | GRALSNAVGN | LGLNSAYGDA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKRLGFDLES | VASQEPDPAL | GNGGLGRLAS | CFLDSMATLN | YPAWGYGLRY | KYGLFKQRIT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KDGQEEAAED | WLELSNPWEI | VRNDVSYPIK | FYGKVVFGSD | GKKRWIGGED | IVAVAYDVPI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PGYKTKTTIN | LRLWSTKAPS | EDFDLSSYNS | GKHTEAAEAL | FNAEKICFVL | YPGDESTEGK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALRLKQQYTL | CSASLQDIVA | RFETRSGGNV | NWEEFPEKVA | VQMNDTHPTL | CIPELMRILM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DLKGLSWEDA | WKITQRTVAY | TNHTVLPEAL | EKWSLELMEK | LLPRHVEIIE | KIDEELVRTI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VSEYGTADPD | LLEEKLKAMR | ILENVELPSA | FADVIVKPVN | KPVTAKDAQN | GVKTEQEEEK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TAGEEEEDEV | IPEPTVEPPK | MVRMANLAVV | GGHAVNGVAE | IHSEIVKQDV | FNDFVQLWPE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KFQNKTNGVT | PRRWIRFCNP | YLSDIITNWI | GTEDWVLNTE | KVAELRKFAD | NEDLQSEWRA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AKKKNKLKVV | SLIKERTGYT | VSPDAMFDIQ | IKRIHEYKRQ | LLNILGIVYR | YKKMKEMSAS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EREKAFVPRV | CIFGGKAFAT | YVQAKRIVKF | ITDVASTINH | DPEIGDLLKV | IFVPDYNVSV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AELLIPASEL | SQHISTAGME | ASGTSNMKFS | MNGCVLIGTL | DGANVEIREE | VGEENFFLFG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AKADQIVNLR | KERAEGKFVP | DPTFEEVKKF | VGSGVFGSNS | YDELIGSLEG | NEGFGRADYF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LVGKDFPSYI | ECQEKVDEAY | RDQKRWTRMS | IMNTAGSFKF | SSDRTIHEYA | KDIWNIKQVE |
| LP |