P09811

PR
Gene name
Pygl
Protein name
Glycogen phosphorylase, liver form
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:64035
EC number
2.4.1.1: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P09811

Entry ID Method Resolution Chain Position Source
AF-P09811-F1 Predicted AlphaFoldDB

No variants for P09811

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P09811

No associated diseases with P09811

1 regional properties for P09811

Type Name Position InterPro Accession
conserved_site Phosphorylase pyridoxal-phosphate attachment site 673 - 685 IPR035090

Functions

Description
EC Number 2.4.1.1 Hexosyltransferases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

12 GO annotations of molecular function

Name Definition
AMP binding Binding to AMP, adenosine monophosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
bile acid binding Binding to a bile acid, a steroid carboxylic acids occurring in bile.
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
glucose binding Binding to D- or L-enantiomers of glucose.
glycogen phosphorylase activity Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate.
identical protein binding Binding to an identical protein or proteins.
linear malto-oligosaccharide phosphorylase activity Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide.
purine nucleobase binding Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
SHG alpha-glucan phosphorylase activity Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan.
vitamin binding Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

6 GO annotations of biological process

Name Definition
5-phosphoribose 1-diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.
glucose homeostasis Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
glycogen catabolic process The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
necroptotic process A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P06738 GPH1 Glycogen phosphorylase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q0VCM4 PYGL Glycogen phosphorylase, liver form Bos taurus (Bovine) PR
P11217 PYGM Glycogen phosphorylase, muscle form Homo sapiens (Human) PR
P11216 PYGB Glycogen phosphorylase, brain form Homo sapiens (Human) PR
P06737 PYGL Glycogen phosphorylase, liver form Homo sapiens (Human) PR
Q9WUB3 Pygm Glycogen phosphorylase, muscle form Mus musculus (Mouse) PR
Q8CI94 Pygb Glycogen phosphorylase, brain form Mus musculus (Mouse) PR
Q9ET01 Pygl Glycogen phosphorylase, liver form Mus musculus (Mouse) PR
P04045 Alpha-1,4 glucan phosphorylase L-1 isozyme, chloroplastic/amyloplastic Solanum tuberosum (Potato) PR
P53535 STP-1 Alpha-1,4 glucan phosphorylase L-2 isozyme, chloroplastic/amyloplastic Solanum tuberosum (Potato) PR
P32811 Alpha-glucan phosphorylase, H isozyme Solanum tuberosum (Potato) PR
P09812 Pygm Glycogen phosphorylase, muscle form Rattus norvegicus (Rat) PR
Q9LIB2 PHS1 Alpha-glucan phosphorylase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SD76 PHS2 Alpha-glucan phosphorylase 2, cytosolic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAKPLTDQEK RRQISIRGIV GVENVAELKK GFNRHLHFTL VKDRNVATPR DYYFALAHTV
70 80 90 100 110 120
RDHLVGRWIR TQQHYYDKCP KRVYYLSLEF YMGRTLQNTM INLGLQNACD EAIYQLGLDM
130 140 150 160 170 180
EELEEIEEDA GLGNGGLGRL AACFLDSMAT LGLAAYGYGI RYEYGIFNQK IREGWQVEEA
190 200 210 220 230 240
DDWLRHGNPW EKARPEFMLP VHFYGRVEHT QAGTKWVDTQ VVLALPYDTP VPGYMNNTVN
250 260 270 280 290 300
TMRLWSARAP NDFNLQDFNV GDYIQAVLDR NLAENISRVL YPNDNFFEGK ELRLKQEYFV
310 320 330 340 350 360
VAATLQDVIR RFKASKFGSK DGVGTVFDAF PDQVAIQLND THPALAIPEL MRIFVDIEKL
370 380 390 400 410 420
PWSKAWEITK KTFAYTNHTV LPEALERWPV DLVEKLLPRH LQIIYEINQK HLDRIVALFP
430 440 450 460 470 480
KDIDRMRRMS LIEEEGGKRI NMAHLCIVGC HAVNGVAKIH SDIVKTQVFK DFSELEPDKF
490 500 510 520 530 540
QNKTNGITPR RWLLLCNPGL ADLIAEKIGE DYVKDLSQLT KLHSFVGDDI FLREIAKVKQ
550 560 570 580 590 600
ENKLKFSQFL EKEYKVKINP SSMFDVHVKR IHEYKRQLLN CLHVITMYNR IKKDPKKFFV
610 620 630 640 650 660
PRTVIIGGKA APGYHMAKMI IKLVTSVAEV VNNDPMVGSK LKVIFLENYR VSLAEKVIPA
670 680 690 700 710 720
TDLSEQISTA GTEASGTGNM KFMLNGALTI GTMDGANVEM AEEAGEENLF IFGMRVDDVA
730 740 750 760 770 780
ALDKKGYEAK EYYEALPELK LVIDQIDNGF FSPNQPDLFK DIINMLFYHD RFKVFADYEA
790 800 810 820 830 840
YVKCQEKVSQ LYMNQKAWNT MVLRNIAASG KFSSDRTIRE YAKDIWNMEP SDLKISLSKE
SSNGVNANGK