AiPD: Autoinhibited Protein Database

Gene name	Pygb
Protein name	Glycogen phosphorylase, brain form
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:110078
EC number	2.4.1.1: Hexosyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-46 (Predicted disordered autoinhibitory region) PR

1-46 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8CI94-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3392234009	77	E>G	No	EVA
rs3392223525	78	R>Q	No	EVA
rs3388599803	97	Q>H	No	EVA
rs3388600361	100	M>V	No	EVA
rs3388595892	112	A>T	No	EVA
rs3392453673	136	G>A	No	EVA
rs3392420232	137	L>P	No	EVA
rs3388592356	148	M>I	No	EVA
rs3388596581	155	A>V	No	EVA
rs3388596626	161	R>Q	No	EVA
rs3388600989	166	I>N	No	EVA
rs3388597642	174	G>V	No	EVA
rs3388592383	183	W>S	No	EVA
rs3392326457	195	P>A	No	EVA
rs3392406977	195	P>Q	No	EVA
rs3392355167	214	V>A	No	EVA
rs3392399256	216	W>L	No	EVA
rs3392381893	218	D>N	No	EVA
rs3388597570	244	L>F	No	EVA
rs3388597549	254	K>R	No	EVA
rs3388590830	323	V>M	No	EVA
rs3388600378	334	V>I	No	EVA
rs3388592358	344	A>T	No	EVA
rs3388593807	348	P>T	No	EVA
rs3388603220	397	L>F	No	EVA
rs262222061	518	Q>H	No	EVA
rs3388599764	520	K>R	No	EVA
rs233534878	521	K>R	No	EVA
rs3388590801	561	A>G	No	EVA
rs3388593844	567	H>R	No	EVA
rs3388600951	598	A>T	No	EVA
rs3388590849	615	H>Q	No	EVA
rs3388595956	641	L>V	No	EVA
rs3388600964	664	S>P	No	EVA
rs3412459739	693	M>I	No	EVA
rs3392326442	694	D>H	No	EVA
rs3388590806	728	N>D	No	EVA
rs3392372282	738	E>Q	No	EVA
rs3388597592	746	I>F	No	EVA
rs3388592406	749	G>S	No	EVA
rs258288147	762	V>M	No	EVA
rs46413053	766	L>M	No	EVA
rs3388593770	784	C>S	No	EVA
rs27372628	790	R>H	No	EVA
rs3388593780	808	C>Y	No	EVA
rs3388597696	843	D>E	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8CI94

		Description
EC Number	2.4.1.1	Hexosyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
carbohydrate binding	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
glycogen phosphorylase activity	Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate.
identical protein binding	Binding to an identical protein or proteins.
linear malto-oligosaccharide phosphorylase activity	Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide.
organic cyclic compound binding	Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
pyridoxal phosphate binding	Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
SHG alpha-glucan phosphorylase activity	Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan.

Name	Definition
glycogen catabolic process	The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
glycogen metabolic process	The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P06738	GPH1	Glycogen phosphorylase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q0VCM4	PYGL	Glycogen phosphorylase, liver form	Bos taurus (Bovine)	PR
P06737	PYGL	Glycogen phosphorylase, liver form	Homo sapiens (Human)	PR
P11217	PYGM	Glycogen phosphorylase, muscle form	Homo sapiens (Human)	PR
P11216	PYGB	Glycogen phosphorylase, brain form	Homo sapiens (Human)	PR
Q9ET01	Pygl	Glycogen phosphorylase, liver form	Mus musculus (Mouse)	PR
Q9WUB3	Pygm	Glycogen phosphorylase, muscle form	Mus musculus (Mouse)	PR
P04045		Alpha-1,4 glucan phosphorylase L-1 isozyme, chloroplastic/amyloplastic	Solanum tuberosum (Potato)	PR
P53535	STP-1	Alpha-1,4 glucan phosphorylase L-2 isozyme, chloroplastic/amyloplastic	Solanum tuberosum (Potato)	PR
P32811		Alpha-glucan phosphorylase, H isozyme	Solanum tuberosum (Potato)	PR
P09812	Pygm	Glycogen phosphorylase, muscle form	Rattus norvegicus (Rat)	PR
P09811	Pygl	Glycogen phosphorylase, liver form	Rattus norvegicus (Rat)	PR
Q9LIB2	PHS1	Alpha-glucan phosphorylase 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SD76	PHS2	Alpha-glucan phosphorylase 2, cytosolic	Arabidopsis thaliana (Mouse-ear cress)	PR