Q9ET01
PR
Gene name |
Pygl |
Protein name |
Glycogen phosphorylase, liver form |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:110095 |
EC number |
2.4.1.1: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9ET01
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9ET01-F1 | Predicted | AlphaFoldDB |
42 variants for Q9ET01
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389228609 | 5 | L>* | No | EVA | |
| rs3389239817 | 6 | T>S | No | EVA | |
| rs3389238679 | 7 | D>A | No | EVA | |
| rs3389238620 | 8 | Q>R | No | EVA | |
| rs3389175844 | 49 | P>L | No | EVA | |
| rs3389245031 | 73 | Q>* | No | EVA | |
| rs3389212039 | 158 | Y>* | No | EVA | |
| rs3403323829 | 166 | I>S | No | EVA | |
| rs242768811 | 212 | T>K | No | EVA | |
| rs3403415140 | 231 | V>M | No | EVA | |
| rs3389202421 | 240 | N>K | No | EVA | |
| rs3389244863 | 255 | L>F | No | EVA | |
| rs3389238925 | 275 | N>I | No | EVA | |
| rs3403323826 | 285 | N>H | No | EVA | |
| rs1132394584 | 292 | L>F | No | EVA | |
| rs3389175877 | 300 | V>M | No | EVA | |
| rs3389215964 | 323 | M>I | No | EVA | |
| rs13467444 | 323 | M>V | No | EVA | |
| rs3389175851 | 325 | T>A | No | EVA | |
| rs3389238907 | 334 | V>A | No | EVA | |
| rs3389202455 | 431 | L>I | No | EVA | |
| rs3389252173 | 457 | A>S | No | EVA | |
| rs3389235937 | 508 | I>L | No | EVA | |
| rs253943490 | 530 | I>L | No | EVA | |
| rs1132546303 | 536 | A>V | No | EVA | |
| rs3389242464 | 571 | I>F | No | EVA | |
| rs3389245030 | 590 | R>L | No | EVA | |
| rs3389235927 | 618 | K>E | No | EVA | |
| rs3389228574 | 620 | I>F | No | EVA | |
| rs3389238975 | 628 | A>T | No | EVA | |
| rs3389202451 | 642 | K>R | No | EVA | |
| rs3389238905 | 698 | V>G | No | EVA | |
| rs3389235993 | 699 | E>V | No | EVA | |
| rs3389250787 | 737 | P>T | No | EVA | |
| rs3402081068 | 748 | N>T | No | EVA | |
| rs3389256995 | 751 | F>L | No | EVA | |
| rs3389239848 | 752 | S>P | No | EVA | |
| rs236953113 | 754 | N>S | No | EVA | |
| rs3389228631 | 759 | F>I | No | EVA | |
| rs3389252144 | 767 | F>L | No | EVA | |
| rs259361037 | 795 | Q>H | No | EVA | |
| rs3389244851 | 804 | K>E | No | EVA |
No associated diseases with Q9ET01
1 regional properties for Q9ET01
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Phosphorylase pyridoxal-phosphate attachment site | 673 - 685 | IPR035090 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.1 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
12 GO annotations of molecular function
| Name | Definition |
|---|---|
| AMP binding | Binding to AMP, adenosine monophosphate. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| bile acid binding | Binding to a bile acid, a steroid carboxylic acids occurring in bile. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| glucose binding | Binding to D- or L-enantiomers of glucose. |
| glycogen phosphorylase activity | Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. |
| identical protein binding | Binding to an identical protein or proteins. |
| linear malto-oligosaccharide phosphorylase activity | Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide. |
| purine nucleobase binding | Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| SHG alpha-glucan phosphorylase activity | Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan. |
| vitamin binding | Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| 5-phosphoribose 1-diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. |
| glucose homeostasis | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. |
| glycogen catabolic process | The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. |
| glycogen metabolic process | The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. |
| necroptotic process | A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P06738 | GPH1 | Glycogen phosphorylase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q0VCM4 | PYGL | Glycogen phosphorylase, liver form | Bos taurus (Bovine) | PR |
| P11217 | PYGM | Glycogen phosphorylase, muscle form | Homo sapiens (Human) | PR |
| P11216 | PYGB | Glycogen phosphorylase, brain form | Homo sapiens (Human) | PR |
| P06737 | PYGL | Glycogen phosphorylase, liver form | Homo sapiens (Human) | PR |
| Q8CI94 | Pygb | Glycogen phosphorylase, brain form | Mus musculus (Mouse) | PR |
| Q9WUB3 | Pygm | Glycogen phosphorylase, muscle form | Mus musculus (Mouse) | PR |
| P04045 | Alpha-1,4 glucan phosphorylase L-1 isozyme, chloroplastic/amyloplastic | Solanum tuberosum (Potato) | PR | |
| P53535 | STP-1 | Alpha-1,4 glucan phosphorylase L-2 isozyme, chloroplastic/amyloplastic | Solanum tuberosum (Potato) | PR |
| P32811 | Alpha-glucan phosphorylase, H isozyme | Solanum tuberosum (Potato) | PR | |
| P09812 | Pygm | Glycogen phosphorylase, muscle form | Rattus norvegicus (Rat) | PR |
| P09811 | Pygl | Glycogen phosphorylase, liver form | Rattus norvegicus (Rat) | PR |
| Q9LIB2 | PHS1 | Alpha-glucan phosphorylase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SD76 | PHS2 | Alpha-glucan phosphorylase 2, cytosolic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKPLTDQEK | RRQISIRGIV | GVENVAELKK | GFNRHLHFTL | VKDRNVATPR | DYYFALAHTV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RDHLVGRWIR | TQQHYYDKCP | KRVYYLSLEF | YMGRTLQNTM | INLGLQNACD | EAIYQLGLDM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EELEEIEEDA | GLGNGGLGRL | AACFLDSMAT | LGLAAYGYGI | RYEYGIFNQK | IREGWQVEEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DDWLRHGNPW | EKARPEFMLP | VHFYGRVEHT | QTGTKWVDTQ | VVLALPYDTP | VPGYMNNTVN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TMRLWSARAP | NDFNLQDFNV | GDYIQAVLDR | NLAENISRVL | YPNDNFFEGK | ELRLKQEYFV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VAATLQDVIR | RFKASKFGSK | DGMGTVFDAF | PDQVAIQLND | THPALAIPEL | MRIFVDIEKL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PWAKAWEITK | KTFAYTNHTV | LPEALERWPV | ELVEKLLPRH | LEIIYEINQK | HLDRIVALFP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KDISRMRRMS | LIEEEGGKRI | NMAHLCIVGC | HAVNGVAKIH | SDIVKTQVFK | DFSELEPDKF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QNKTNGITPR | RWLLLCNPGL | ADLIAEKIGE | DYVKDLSQLT | KLHSFVSDDI | FLREIAKVKQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ENKLKFSQFL | EKEYKVKINP | SSMFDVHVKR | IHEYKRQLLN | CLHVITMYNR | IKKDPKKFFV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PRTVIIGGKA | APGYHMAKMI | IKLITSVAEV | VNNDPMVGSK | LKVIFLENYR | VSLAEKVIPA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TDLSEQISTA | GTEASGTGNM | KFMLNGALTI | GTMDGANVEM | AEEAGEENLF | IFGMRVDDVA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ALDKKGYEAK | EYYEALPELK | LVIDQIDNGF | FSPNQPDLFK | DIINMLFYHD | RFKVFADYEA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YVKCQEKVSQ | LYMNQKAWNT | MVLKNIAASG | KFSSDRTIKE | YAKDIWNMEP | SDLKISLSNE |
| SSNGVSANGK |