Q0VCM4

PR
Gene name
PYGL
Protein name
Glycogen phosphorylase, liver form
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:505472
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0VCM4

Entry ID Method Resolution Chain Position Source
AF-Q0VCM4-F1 Predicted AlphaFoldDB

138 variants for Q0VCM4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs452248696 6 T>P No EVA
rs440164414 13 Q>R No EVA
rs473004206 15 S>R No EVA
rs454517017 16 I>L No EVA
rs436069571 17 R>C No EVA
rs436069571 17 R>S No EVA
rs469030965 18 G>C No EVA
rs465675620 19 I>M No EVA
rs431918217 19 I>S No EVA
rs447126983 20 V>A No EVA
rs467965139 22 V>M No EVA
rs449437572 23 E>G No EVA
rs482398594 25 V>G No EVA
rs463831278 28 L>R No EVA
rs438791361 29 K>N No EVA
rs478199811 32 F>C No EVA
rs440252611 35 H>Q No EVA
rs458722429 35 H>R No EVA
rs473042973 39 T>A No EVA
rs473042973 39 T>P No EVA
rs442583682 41 V>A No EVA
rs442583682 41 V>G No EVA
rs456982984 42 K>T No EVA
rs464960507 46 V>A No EVA
rs431962106 46 V>L No EVA
rs453669340 47 A>P No EVA
rs435062480 48 T>P No EVA
rs468001335 50 R>L No EVA
rs433736796 51 D>E No EVA
rs449410365 53 F>L No EVA
rs470272365 61 R>L No EVA
rs466855877 62 D>Y No EVA
rs445323393 63 H>P No EVA
rs478292574 65 V>G No EVA
rs459566789 66 G>W No EVA
rs446726929 67 R>L No EVA
rs479537073 68 W>C No EVA
rs461046290 80 P>L No EVA
rs447420383 103 L>R No EVA
rs442775873 119 D>G No EVA
rs474929438 122 E>G No EVA
rs456369187 123 L>V No EVA
rs479687312 143 C>W No EVA
rs461135512 148 M>R No EVA
rs442558340 150 T>P No EVA
rs719324977 151 L>V No EVA
rs438424166 153 L>P No EVA
rs453671236 157 G>R No EVA
rs441479739 158 Y>* No EVA
rs455941072 161 R>L No EVA
rs470121887 162 Y>D No EVA
rs433196309 166 I>M No EVA
rs446740107 168 N>K No EVA
rs479772658 169 Q>K No EVA
rs467614279 170 K>N No EVA
rs449072343 171 I>L No EVA
rs463488418 172 R>Q No EVA
rs211238111 217 T>I No EVA
rs442486181 224 A>D No EVA
rs475394035 229 T>A No EVA
rs110486343 326 A>V No EVA
rs472449443 354 F>L No EVA
rs439471927 354 F>Y No EVA
rs460195768 355 V>M No EVA
rs441718808 362 W>* No EVA
rs456062512 363 S>F No EVA
rs474515467 363 S>T No EVA
rs437631540 364 K>E No EVA
rs470583974 364 K>R No EVA
rs464012713 368 I>V No EVA
rs439031247 372 T>A No EVA
rs453414744 390 V>A No EVA
rs434864721 391 E>K No EVA
rs474075603 394 E>A No EVA
rs455577655 402 Q>L No EVA
rs437149847 405 Y>S No EVA
rs469350216 412 L>I No EVA
rs799209096 424 D>N No EVA
rs478550332 428 R>S No EVA
rs459836820 460 H>P No EVA
rs441414905 465 K>N No EVA
rs480600402 466 T>I No EVA
rs462117109 467 Q>E No EVA
rs443710366 467 Q>R No EVA
rs476713536 468 V>I No EVA
rs462054942 469 F>S No EVA
rs443529905 472 F>V No EVA
rs476488499 472 F>Y No EVA
rs439324085 473 S>I No EVA
rs457947689 473 S>R No EVA
rs472146771 474 E>K No EVA
rs453679179 475 L>R No EVA
rs441592765 478 D>G No EVA
rs474392294 479 K>R No EVA
rs456030312 480 F>I No EVA
rs464777302 482 N>D No EVA
rs452684751 483 K>T No EVA
rs434157746 484 T>S No EVA
rs448583542 486 G>V No EVA
rs467114011 486 G>W No EVA
rs481479915 490 R>S No EVA
rs469425917 491 R>S No EVA
rs450751053 492 W>L No EVA
rs482978374 497 N>H No EVA
rs457959401 497 N>K No EVA
rs439413712 500 L>R No EVA
rs460108737 503 L>V No EVA
rs478276149 507 K>E No EVA
rs480561700 508 I>M No EVA
rs447755785 508 I>V No EVA
rs462248688 512 Y>* No EVA
rs443625056 513 V>G No EVA
rs476624846 518 Q>E No EVA
rs438743959 530 I>V No EVA
rs443293118 547 S>Y No EVA
rs454259690 551 E>D No EVA
rs472906343 610 A>V No EVA
rs455090659 659 P>A No EVA
rs475908982 665 E>* No EVA
rs457210630 665 E>D No EVA
rs433837172 684 L>Q No EVA
rs461033203 687 A>T No EVA
rs466753030 688 L>Q No EVA
rs481188596 693 M>R No EVA
rs469094248 705 G>W No EVA
rs450565547 706 E>V No EVA
rs476981777 717 E>D No EVA
rs458494910 722 L>* No EVA
rs440763222 723 D>N No EVA
rs480102211 723 D>V No EVA
rs461515772 724 K>E No EVA
rs443002480 724 K>R No EVA
rs438650519 774 V>I No EVA
rs471605550 781 Y>* No EVA
rs385539463 784 C>* No EVA
rs468303859 796 K>E No EVA
rs449820834 813 S>A No EVA
rs482605802 819 K>E No EVA

No associated diseases with Q0VCM4

1 regional properties for Q0VCM4

Type Name Position InterPro Accession
conserved_site Phosphorylase pyridoxal-phosphate attachment site 673 - 685 IPR035090

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
glycogen phosphorylase activity Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate.
linear malto-oligosaccharide phosphorylase activity Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
SHG alpha-glucan phosphorylase activity Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan.

1 GO annotations of biological process

Name Definition
glycogen catabolic process The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P06738 GPH1 Glycogen phosphorylase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P11217 PYGM Glycogen phosphorylase, muscle form Homo sapiens (Human) PR
P11216 PYGB Glycogen phosphorylase, brain form Homo sapiens (Human) PR
P06737 PYGL Glycogen phosphorylase, liver form Homo sapiens (Human) PR
Q9WUB3 Pygm Glycogen phosphorylase, muscle form Mus musculus (Mouse) PR
Q8CI94 Pygb Glycogen phosphorylase, brain form Mus musculus (Mouse) PR
Q9ET01 Pygl Glycogen phosphorylase, liver form Mus musculus (Mouse) PR
P04045 Alpha-1,4 glucan phosphorylase L-1 isozyme, chloroplastic/amyloplastic Solanum tuberosum (Potato) PR
P53535 STP-1 Alpha-1,4 glucan phosphorylase L-2 isozyme, chloroplastic/amyloplastic Solanum tuberosum (Potato) PR
P32811 Alpha-glucan phosphorylase, H isozyme Solanum tuberosum (Potato) PR
P09812 Pygm Glycogen phosphorylase, muscle form Rattus norvegicus (Rat) PR
P09811 Pygl Glycogen phosphorylase, liver form Rattus norvegicus (Rat) PR
Q9LIB2 PHS1 Alpha-glucan phosphorylase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SD76 PHS2 Alpha-glucan phosphorylase 2, cytosolic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAKPLTDQEK RRQISIRGIV GVENVAELKK GFNRHLHFTL VKDRNVATPR DYFFALAHTV
70 80 90 100 110 120
RDHLVGRWIR TQQYYYEKCP KRVYYLSLEF YMGRTLQNTM INLGLQNACD EAIYQLGLDM
130 140 150 160 170 180
EELEEIEEDA GLGNGGLGRL AACFLDSMAT LGLAAYGYGI RYEYGIFNQK IRDGWQIEEA
190 200 210 220 230 240
DDWLRHGNPW EKARPEFMLP VHFYGRVEHT EAGTKWTDTQ VVLALPYDTP VPGYLNNTVN
250 260 270 280 290 300
TMRLWSARAP NDFNLRDFNV GDYIQAVLDR NLAENISRVL YPNDNFFEGK ELRLKQEYFV
310 320 330 340 350 360
VAATLQDVIR RFKASKFDSS NSTKTAFDAF PDQVAIQLND THPSLAIPEL MRIFVDIEKL
370 380 390 400 410 420
PWSKAWEITQ KTFAYTNHTV LPEALERWPV ELVEKLLPRH LQIIYEINQK HLDKIAALFP
430 440 450 460 470 480
KDVDRLRRMS LIEEEGGKRI NMAHLCIVGS HAVNGVAKIH SDIVKTQVFK DFSELEPDKF
490 500 510 520 530 540
QNKTNGITPR RWLLLCNPGL AELIAEKIGE DYVKDLSQLT KLNSFLGDDI FLREISNVKQ
550 560 570 580 590 600
ENKLKFSQFL EKEYKVKINP SSMFDVQVKR IHEYKRQLLN CLHVVTMYNR IKKDPKKLFV
610 620 630 640 650 660
PRTVIIGGKA APGYYMAKLI IKLITSVAEV VNNDPVVGSK LKLIFLENYR VSLAEKVIPA
670 680 690 700 710 720
TDLSEQISTA GTEASGTGNM KFMLNGALTI GTMDGANVEM AEEAGEENLF IFGMRIEDVA
730 740 750 760 770 780
ALDKKGYEAK EYYEALPELK LAIDQIDKGF FSPKQPDLFK DLVNMLFYHD RFKVFADYEA
790 800 810 820 830 840
YVKCQEKVSQ LYMNPKAWNI MVLKNIAASG KFSSDRTIKE YARDIWNMEP SDIKISLSSD
850
PSGGANKANG K