Q9QYJ1
Gene name |
St6galnac5 (Siat7e) |
Protein name |
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 |
Names |
GD1 alpha synthase, GalNAc alpha-2,6-sialyltransferase V, ST6GalNAc V, ST6GalNAcV, Sialyltransferase 7E, SIAT7-E |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:26938 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9QYJ1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QYJ1-F1 | Predicted | AlphaFoldDB |
2 variants for Q9QYJ1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 48 | Q>del | strain: C57BL/6J [UniProt] | No | ||
| 49 | Q>del | strain: C57BL/6N and C57BL/6J [UniProt] | No |
No associated diseases with Q9QYJ1
No regional properties for Q9QYJ1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9QYJ1 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. |
| sialyltransferase activity | Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| ganglioside biosynthetic process | The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. |
| glycosphingolipid biosynthetic process | The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. |
| oligosaccharide biosynthetic process | The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. |
| oligosaccharide metabolic process | The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q92184 | ST6GALNAC2 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Gallus gallus (Chicken) | PR |
| Q92182 | ST6GAL1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Gallus gallus (Chicken) | PR |
| Q701R0 | ST6GAL2 | Beta-galactoside alpha-2,6-sialyltransferase 2 | Gallus gallus (Chicken) | PR |
| P15907 | ST6GAL1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Homo sapiens (Human) | PR |
| Q9UJ37 | ST6GALNAC2 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Homo sapiens (Human) | PR |
| Q96JF0 | ST6GAL2 | Beta-galactoside alpha-2,6-sialyltransferase 2 | Homo sapiens (Human) | PR |
| Q9BVH7 | ST6GALNAC5 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | Homo sapiens (Human) | PR |
| Q64685 | St6gal1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Mus musculus (Mouse) | PR |
| P70277 | St6galnac2 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Mus musculus (Mouse) | PR |
| P13721 | St6gal1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q9SGD2 | GALT29A | Beta-1,6-galactosyltransferase GALT29A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKTLMRHGLA | VCLVLTTMCT | SLLLVYSSLG | SQKERPPQQQ | QQQQQQQQQA | ATATGSTQLV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ESSPQPRRTA | PAGPRQLEGY | LGVADHKPLK | MHCKDCALVT | SSGHLLRSQQ | GPHIDQTECV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IRMNDAPTRG | YGLDVGNRTS | LRVIAHSSIQ | RILRNRHDLL | NVSQGTVFIF | WGPSSYMRRD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GKGQAYNNLQ | LLSQVLPRLK | AFMITRHRML | QFDELFKQET | GKDRKISNTW | LSTGWFTMTI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALELCDRIDV | YGMVPPDFCR | DPKHPSVPYH | YYEPSGPDEC | TMYLSHERGR | KGSHHRFITE |
| 310 | 320 | 330 | |||
| KRVFKNWART | FNIHFFQPDW | KPESPAVNHA | EGKPVF |