Q701R0
Gene name |
ST6GAL2 |
Protein name |
Beta-galactoside alpha-2,6-sialyltransferase 2 |
Names |
Alpha 2,6-ST 2, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2, ST6Gal II, ST6GalII, Sialyltransferase 2 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:403122 |
EC number |
2.4.3.1: Sialyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q701R0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q701R0-F1 | Predicted | AlphaFoldDB |
No variants for Q701R0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q701R0 | |||||
No associated diseases with Q701R0
No regional properties for Q701R0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q701R0 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.3.1 | Sialyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi cisterna membrane | The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-galactoside alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
| sialylation | The covalent attachment of sialic acid to a substrate molecule. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q92184 | ST6GALNAC2 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Gallus gallus (Chicken) | PR |
| Q92182 | ST6GAL1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Gallus gallus (Chicken) | PR |
| P15907 | ST6GAL1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Homo sapiens (Human) | PR |
| Q9UJ37 | ST6GALNAC2 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Homo sapiens (Human) | PR |
| Q9BVH7 | ST6GALNAC5 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | Homo sapiens (Human) | PR |
| Q96JF0 | ST6GAL2 | Beta-galactoside alpha-2,6-sialyltransferase 2 | Homo sapiens (Human) | PR |
| Q64685 | St6gal1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Mus musculus (Mouse) | PR |
| Q9QYJ1 | St6galnac5 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | Mus musculus (Mouse) | PR |
| P70277 | St6galnac2 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Mus musculus (Mouse) | PR |
| P13721 | St6gal1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q9SGD2 | GALT29A | Beta-1,6-galactosyltransferase GALT29A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKPNLKQWKQ | LMLFGIFAWG | LLFLVIFIYF | TDSNSAEPVP | SSFSYIETKR | LLPLQGKQRV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IMGAIHDPSF | SEAIDGNEVL | LNEDLLDTFK | SETGSIKKWT | DLEDAFRSED | EFFPSQIGRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SKSAFYQVND | DYLFAAGQPM | SHNSFQEIAK | FISADEDNPK | ESILQNNWSR | QRRMRRRSTK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HRRSQMLDES | DDWDGLYSTM | SKSFLYKLWK | GDVSSKMLNP | RLQKAMKDYL | STNKHGVRFK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GKRNSKLTGD | QLFCELKERV | DVKTIDGKEA | PFSTLGWEKH | VPQIPLGKLY | THGFGSCAVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MSAGAILNSS | LGDEIDSHDA | VLRFNSAPTR | GYEKDVGNKT | TMRIINSQIL | TNPNHHFVDS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SLYKDVILVA | WDPAPYSANL | NWYKKPDYNL | FTPYVQHRKK | NPNQPFYILH | PKFIWQLWDI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IQENTKEKIQ | PNPPSSGFIG | ILIMMSMCNE | VHVYEYIPSV | RQTDLCHYHE | LYYDAACTLG |
| 490 | 500 | 510 | 520 | ||
| AYHPLLYEKL | LVQRMNKGLQ | DDLYRKGKVI | LPGFKSVKCP | ERNNFPPL |