P13721

PR
Gene name
St6gal1 (Siat1)
Protein name
Beta-galactoside alpha-2,6-sialyltransferase 1
Names
Alpha 2,6-ST 1, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1, ST6Gal I, ST6GalI, Sialyltransferase 1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25197
EC number
2.4.3.1: Sialyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P13721

Entry ID Method Resolution Chain Position Source
4MPS X-ray 240 A A/B 95-403 PDB
AF-P13721-F1 Predicted AlphaFoldDB

No variants for P13721

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P13721

No associated diseases with P13721

No regional properties for P13721

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P13721

Functions

Description
EC Number 2.4.3.1 Sialyltransferases
Subcellular Localization
  • Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein
  • Secreted
  • Membrane-bound form in trans cisternae of Golgi
  • Secreted into the body fluid
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.
Golgi medial cisterna The middle Golgi cisterna (or cisternae).
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
Golgi trans cisterna The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
beta-galactoside alpha-2,6-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine.
protein homodimerization activity Binding to an identical protein to form a homodimer.
sialyltransferase activity Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.

10 GO annotations of biological process

Name Definition
N-acetylneuraminate metabolic process The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid.
negative regulation of chemotaxis Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
negative regulation of macrophage apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process.
positive regulation of mononuclear cell proliferation Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
protein N-linked glycosylation via asparagine The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.
protein sialylation A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein.
regulation of substrate adhesion-dependent cell spreading Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading.
response to ethanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
sialylation The covalent attachment of sialic acid to a substrate molecule.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q92184 ST6GALNAC2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Gallus gallus (Chicken) PR
Q701R0 ST6GAL2 Beta-galactoside alpha-2,6-sialyltransferase 2 Gallus gallus (Chicken) PR
Q92182 ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 Gallus gallus (Chicken) PR
Q9UJ37 ST6GALNAC2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Homo sapiens (Human) PR
Q96JF0 ST6GAL2 Beta-galactoside alpha-2,6-sialyltransferase 2 Homo sapiens (Human) PR
Q9BVH7 ST6GALNAC5 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Homo sapiens (Human) PR
P15907 ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 Homo sapiens (Human) PR
Q9QYJ1 St6galnac5 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Mus musculus (Mouse) PR
P70277 St6galnac2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Mus musculus (Mouse) PR
Q64685 St6gal1 Beta-galactoside alpha-2,6-sialyltransferase 1 Mus musculus (Mouse) PR
Q9SGD2 GALT29A Beta-1,6-galactosyltransferase GALT29A Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MIHTNLKKKF SLFILVFLLF AVICVWKKGS DYEALTLQAK EFQMPKSQEK VAMGSASQVV
70 80 90 100 110 120
FSNSKQDPKE DIPILSYHRV TAKVKPQPSF QVWDKDSTYS KLNPRLLKIW RNYLNMNKYK
130 140 150 160 170 180
VSYKGPGPGV KFSVEALRCH LRDHVNVSMI EATDFPFNTT EWEGYLPKEN FRTKVGPWQR
190 200 210 220 230 240
CAVVSSAGSL KNSQLGREID NHDAVLRFNG APTDNFQQDV GSKTTIRLMN SQLVTTEKRF
250 260 270 280 290 300
LKDSLYTEGI LIVWDPSVYH ADIPKWYQKP DYNFFETYKS YRRLNPSQPF YILKPQMPWE
310 320 330 340 350 360
LWDIIQEISA DLIQPNPPSS GMLGIIIMMT LCDQVDIYEF LPSKRKTDVC YYHQKFFDSA
370 380 390 400
CTMGAYHPLL FEKNMVKHLN EGTDEDIYLF GKATLSGFRN IRC