P70277

PR
Gene name
St6galnac2 (Siat7, Siat7b)
Protein name
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Names
Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase, GalNAc alpha-2,6-sialyltransferase II, ST6GalNAc II, ST6GalNAcII, Sialyltransferase 7B, SIAT7-B
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20446
EC number
2.4.3.3: Sialyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-167 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P70277

Entry ID Method Resolution Chain Position Source
AF-P70277-F1 Predicted AlphaFoldDB

27 variants for P70277

Variant ID(s) Position Change Description Diseaes Association Provenance
rs254162370 24 M>L No EVA
rs27029074 63 R>Q No EVA
rs3389209208 68 S>* No EVA
rs3389155485 73 I>S No EVA
rs3389182062 84 D>E No EVA
rs262656205 121 I>V No EVA
rs245601272 132 E>G No EVA
rs29443155 139 A>T No EVA
rs241872583 170 A>D No EVA
rs228869588 187 R>H No EVA
rs3389155545 201 N>S No EVA
rs3389235250 224 L>M No EVA
rs3402757707 234 R>S No EVA
rs3402434491 236 Y>* No EVA
rs3401584672 237 L>R No EVA
rs3389195834 252 P>H No EVA
rs3413051004 253 D>E No EVA
rs265850741 295 R>L No EVA
rs265850741 295 R>Q No EVA
rs3389218393 306 A>V No EVA
rs3402942428 317 D>H No EVA
rs1133394557 325 I>M No EVA
rs3389189689 328 N>D No EVA
rs1134683392 328 N>K No EVA
rs3389220012 330 Q>* No EVA
rs3389214737 348 A>T No EVA
rs3389223985 374 R>D No EVA

No associated diseases with P70277

No regional properties for P70277

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P70277

Functions

Description
EC Number 2.4.3.3 Sialyltransferases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

3 GO annotations of biological process

Name Definition
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
protein O-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.
protein sialylation A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q92182 ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 Gallus gallus (Chicken) PR
Q701R0 ST6GAL2 Beta-galactoside alpha-2,6-sialyltransferase 2 Gallus gallus (Chicken) PR
Q92184 ST6GALNAC2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Gallus gallus (Chicken) PR
P15907 ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 Homo sapiens (Human) PR
Q96JF0 ST6GAL2 Beta-galactoside alpha-2,6-sialyltransferase 2 Homo sapiens (Human) PR
Q9BVH7 ST6GALNAC5 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Homo sapiens (Human) PR
Q9UJ37 ST6GALNAC2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Homo sapiens (Human) PR
Q64685 St6gal1 Beta-galactoside alpha-2,6-sialyltransferase 1 Mus musculus (Mouse) PR
Q9QYJ1 St6galnac5 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Mus musculus (Mouse) PR
P13721 St6gal1 Beta-galactoside alpha-2,6-sialyltransferase 1 Rattus norvegicus (Rat) PR
Q9SGD2 GALT29A Beta-1,6-galactosyltransferase GALT29A Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDLPRRWLFR MLLLVATSSG ILLMLYSSAG QQSPETQVPA RNMAYPRAFF DPKPPNSENR
70 80 90 100 110 120
KSRLCQHSLS LAIQKDRRFR SLFDLSTPVL LWEGLFTQEL WNNLSQHKVP YGWQGLSHEV
130 140 150 160 170 180
IASTLRLLKS PESGELFGAP RKLPLSCIRC AVVGNGGILN GSRQGQKIDA HDYVFRLNGA
190 200 210 220 230 240
ITEGFERDVG TKTSFYGFTV NTMKNSLISY AKLGFTSVPQ GQNLRYIFIP SSIRDYLMLR
250 260 270 280 290 300
SAILGVPVPE GPDKGDRPHT YFGPETSASK FKLLHPDFIS YLTERFLKSK LINTRFGDMY
310 320 330 340 350 360
MPSTGALMLL TALHTCDQVS AYGFITNNYQ KYSDHYFERE KKPLIFYANH DLSLEASLWR
370
DLHNAGILWL YQR