P15907
PR
Gene name |
ST6GAL1 (SIAT1) |
Protein name |
Beta-galactoside alpha-2,6-sialyltransferase 1 |
Names |
Alpha 2,6-ST 1, B-cell antigen CD75, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1, ST6Gal I, ST6GalI, Sialyltransferase 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:6480 |
EC number |
2.4.3.1: Sialyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for P15907
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4JS1 | X-ray | 209 A | A | 89-406 | PDB |
| 4JS2 | X-ray | 230 A | A | 89-406 | PDB |
| 6QVS | X-ray | 160 A | A/B | 132-406 | PDB |
| 6QVT | X-ray | 170 A | A/B | 132-406 | PDB |
| AF-P15907-F1 | Predicted | AlphaFoldDB |
293 variants for P15907
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs754480789 CA89906366 |
4 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA2748067 rs754480789 |
4 | T>N | No |
ClinGen ExAC gnomAD |
|
|
rs1336912082 CA355846958 |
5 | N>H | No |
ClinGen gnomAD |
|
|
CA355846962 rs1483350433 |
5 | N>S | No |
ClinGen gnomAD |
|
|
CA2748068 rs781047841 |
6 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1579351552 CA355846974 |
7 | K>R | No |
ClinGen Ensembl |
|
|
CA2748069 rs747797139 |
8 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA355846981 rs1560173325 |
8 | K>R | No |
ClinGen Ensembl |
|
|
CA355846998 rs1173064800 |
10 | F>C | No |
ClinGen TOPMed |
|
| TCGA novel | 12 | C>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs770801889 CA355847025 |
14 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770801889 CA2748073 |
14 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770801889 CA89906367 |
14 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA355847030 rs1173327620 |
15 | L>V | No |
ClinGen gnomAD |
|
|
CA2748074 rs774309227 |
16 | V>F | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 18 | L>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1460870059 CA355847049 |
18 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA2748075 rs747110392 |
21 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776908493 CA2748077 |
23 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1435899723 CA355847081 |
23 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
rs538219161 CA2748076 |
23 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1367190687 CA355847083 |
24 | C>R | No |
ClinGen gnomAD |
|
|
rs372532525 CA2748078 |
24 | C>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2748079 rs765387130 |
25 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765387130 CA89906369 |
25 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 28 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA355847133 rs1333293311 |
30 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA355847130 rs1312535523 |
30 | K>R | No |
ClinGen gnomAD |
|
|
CA355847146 rs1211853675 |
32 | G>A | No |
ClinGen gnomAD |
|
|
rs1560173399 CA355847144 |
32 | G>R | No |
ClinGen Ensembl |
|
|
CA548799922 rs1258582790 |
34 | Y>* | No |
ClinGen gnomAD |
|
|
rs905099697 CA89906370 |
35 | Y>N | No |
ClinGen TOPMed |
|
|
CA355847166 rs1208739712 |
35 | Y>S | No |
ClinGen gnomAD |
|
|
rs1446756819 CA355847171 |
36 | D>N | No |
ClinGen TOPMed |
|
|
rs1250447742 CA355847186 |
38 | F>L | No |
ClinGen gnomAD |
|
|
CA89906371 rs1003490678 |
39 | K>I | No |
ClinGen TOPMed |
|
|
rs1453072162 CA355847199 |
39 | K>N | No |
ClinGen gnomAD |
|
| TCGA novel | 39 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1193426631 CA355847207 |
41 | Q>K | No |
ClinGen gnomAD |
|
|
rs376769275 CA2748082 |
43 | K>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA355847252 rs1468378068 |
46 | Q>H | No |
ClinGen TOPMed |
|
|
CA89906372 rs1034480430 |
46 | Q>R | No |
ClinGen Ensembl |
|
|
rs1230779156 CA355847272 |
49 | K>N | No |
ClinGen TOPMed |
|
|
rs766835893 CA2748084 |
50 | S>I | No |
ClinGen ExAC gnomAD |
|
|
CA355847282 rs1322593876 |
51 | L>V | No |
ClinGen gnomAD |
|
|
rs752093218 CA2748085 |
54 | L>S | No |
ClinGen ExAC gnomAD |
|
|
rs373712458 CA2748086 |
55 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2748088 rs752196419 |
56 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA2748087 rs767139133 |
56 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA2748089 rs755850692 |
57 | G>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 58 | S>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs142344871 CA2748090 |
58 | S>Y | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs749074261 CA2748091 |
60 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1269422200 CA355847354 |
62 | S>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 63 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs983899606 CA89906374 |
64 | S>F | No |
ClinGen TOPMed |
|
|
rs757051175 CA2748092 |
66 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1405425072 CA355847378 |
66 | S>R | No |
ClinGen gnomAD |
|
|
CA2748094 rs778777723 |
68 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA2748095 rs771931718 |
68 | T>I | Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA2748093 rs778777723 |
68 | T>S | No |
ClinGen ExAC gnomAD |
|
|
rs748178562 CA2748097 |
70 | D>G | No |
ClinGen ExAC |
|
|
rs368632124 CA2748098 |
71 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs774730961 CA2748100 |
72 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773452361 CA2748099 |
72 | H>R | No |
ClinGen ExAC gnomAD |
|
|
rs1201863290 CA355847428 |
74 | G>V | No |
ClinGen TOPMed |
|
|
rs151284888 CA2748101 COSM1042391 |
75 | R>C | Variant assessed as Somatic; 4.623e-05 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs558830065 CA2748102 |
75 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA355847442 rs1164064322 |
77 | T>A | No |
ClinGen gnomAD |
|
|
rs140438545 CA2748103 |
78 | L>F | No |
ClinGen ESP ExAC gnomAD |
|
|
rs768086412 CA355847450 |
78 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768086412 CA2748104 |
78 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1335084072 CA355847453 |
79 | G>D | No |
ClinGen TOPMed |
|
|
rs150410379 CA2748106 |
79 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA89906379 rs763884230 |
80 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2748109 rs370846354 |
80 | S>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2748108 rs370846354 |
80 | S>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2748107 rs763884230 |
80 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA355847482 rs1322169974 |
84 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
rs778776277 CA355847479 |
84 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750130755 CA2748111 |
86 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs758356511 CA2748112 |
86 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201339364 CA89906380 |
87 | A>D | No |
ClinGen Ensembl |
|
|
CA355847502 rs1323988775 |
88 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
rs1579352073 CA355847523 |
91 | A>T | No |
ClinGen Ensembl |
|
|
CA355847531 rs1232712342 |
92 | S>F | No |
ClinGen gnomAD |
|
|
CA89906381 rs200149315 |
92 | S>P | No |
ClinGen gnomAD |
|
|
CA355847536 rs1444990041 |
93 | F>V | No |
ClinGen TOPMed |
|
|
rs748266782 CA2748114 |
94 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs767740098 CA89906383 |
95 | V>L | No |
ClinGen Ensembl |
|
|
rs1260365970 CA355847560 |
96 | W>* | No |
ClinGen TOPMed |
|
| TCGA novel | 96 | W>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA355847585 rs1474927008 |
99 | D>E | No |
ClinGen gnomAD |
|
|
rs1560173635 CA355847591 COSM1042393 |
100 | S>N | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
CA355847611 rs1182448647 |
103 | K>I | No |
ClinGen gnomAD |
|
|
CA2748115 rs769842676 |
106 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA355847637 rs1406972256 |
107 | P>S | No |
ClinGen gnomAD |
|
|
CA2748116 rs777923061 |
110 | Q>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 111 | K>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA89906384 rs575421483 |
112 | I>T | No |
ClinGen Ensembl |
|
|
rs987759918 CA89906385 |
117 | L>Q | No |
ClinGen TOPMed |
|
|
rs935522265 CA89906387 |
118 | S>I | No |
ClinGen TOPMed |
|
|
CA89906388 rs770999685 |
119 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2748118 rs770999685 |
119 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA89906390 rs946491486 |
122 | Y>* | No |
ClinGen TOPMed gnomAD |
|
|
rs893553458 CA89906389 |
122 | Y>F | No |
ClinGen TOPMed |
|
|
CA2748119 rs774799258 |
123 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA355847759 rs1324920923 |
124 | V>A | No |
ClinGen TOPMed |
|
|
rs1274545122 CA355847756 |
124 | V>L | No |
ClinGen gnomAD |
|
|
rs1274545122 CA355847755 |
124 | V>M | No |
ClinGen gnomAD |
|
|
CA2748121 rs772743022 |
127 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA355847798 rs1239339370 |
130 | G>A | No |
ClinGen gnomAD |
|
|
rs1404750320 CA355847812 |
133 | I>L | No |
ClinGen TOPMed |
|
|
rs142229283 CA355847838 |
136 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs142229283 CA2748123 |
136 | S>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs146159160 CA2748124 COSM1042394 |
137 | A>T | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA355847846 rs1474195377 |
137 | A>V | No |
ClinGen TOPMed |
|
|
rs1036404925 CA89906394 |
139 | A>S | No |
ClinGen gnomAD |
|
|
CA355847855 rs1036404925 |
139 | A>T | No |
ClinGen gnomAD |
|
|
CA2748125 rs138824619 |
141 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs761543274 CA2748126 |
141 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA355847867 rs761543274 |
141 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs377510121 CA2748127 |
143 | H>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2748130 rs149308342 |
145 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA2748129 COSM3719366 rs527877833 |
145 | R>W | Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs1366467487 CA355847916 |
149 | N>D | No |
ClinGen gnomAD |
|
|
CA2748131 rs751485938 |
151 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs754842583 CA2748132 |
153 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs968006280 CA89906399 |
157 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
rs771215054 CA89906398 |
157 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771215054 CA2748135 |
157 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771215054 CA355847968 |
157 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1435592154 CA355847987 |
160 | F>L | No |
ClinGen TOPMed |
|
|
CA2748136 rs778969734 |
161 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA355847998 rs778969734 |
161 | N>T | No |
ClinGen ExAC gnomAD |
|
|
rs746281001 CA2748137 |
162 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs144486229 CA2748139 |
164 | E>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2748140 rs747527436 |
165 | W>R | No |
ClinGen ExAC gnomAD |
|
|
rs768988754 CA2748141 |
166 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs776230435 CA2748142 |
167 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1172858109 CA355848038 |
167 | G>V | No |
ClinGen gnomAD |
|
|
CA2748143 rs761190193 |
170 | P>H | No |
ClinGen ExAC gnomAD |
|
|
CA89906401 rs935622576 |
170 | P>S | No |
ClinGen TOPMed |
|
|
CA355848064 rs1398454149 |
171 | K>N | No |
ClinGen gnomAD |
|
|
CA355848060 rs1579352449 |
171 | K>R | No |
ClinGen Ensembl |
|
|
CA2748144 rs764983228 |
172 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200865084 CA2748145 |
173 | S>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA355848079 rs1560173813 |
174 | I>L | No |
ClinGen Ensembl |
|
|
rs751297612 CA2748148 |
177 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2748149 rs754929372 |
179 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs753987883 CA2748151 |
180 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA89906402 rs1033386410 |
180 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA355848127 rs1247829228 COSM1227679 |
181 | W>* | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed |
| TCGA novel | 183 | R>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA355848142 rs1268900006 |
183 | R>S | No |
ClinGen gnomAD |
|
|
rs1227899080 CA355848136 |
183 | R>W | No |
ClinGen gnomAD |
|
|
CA355848145 rs1579352509 |
184 | C>G | No |
ClinGen Ensembl |
|
|
CA355848174 rs1331287018 |
188 | S>L | No |
ClinGen TOPMed gnomAD |
|
|
rs746081323 CA2748154 |
192 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs1320276116 CA355848214 |
195 | S>Y | No |
ClinGen TOPMed |
|
|
CA355848222 rs1471375432 |
196 | S>F | No |
ClinGen gnomAD |
|
|
CA355848225 rs1218753084 |
197 | Q>* | No |
ClinGen TOPMed |
|
|
rs747333324 CA2748157 |
199 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA355848241 rs1368453583 |
200 | R>G | No |
ClinGen TOPMed |
|
| TCGA novel | 201 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs769241343 | 202 | I>= | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA355849175 rs748717915 |
203 | D>E | No |
ClinGen gnomAD |
|
|
CA89906406 rs200944757 |
203 | D>N | No |
ClinGen TOPMed |
|
|
CA355849181 rs1339877596 |
204 | D>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA355849185 rs1452041754 |
204 | D>V | No |
ClinGen TOPMed |
|
|
CA2748181 rs777284898 |
205 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2748183 rs770609191 |
207 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA2748184 rs770609191 |
207 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA355849286 rs1423883787 |
212 | N>D | No |
ClinGen gnomAD |
|
|
rs1190289289 CA355849297 |
213 | G>R | No |
ClinGen gnomAD |
|
|
rs1169572938 CA355849392 |
220 | Q>H | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 221 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs775286088 CA2748187 |
222 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA355849435 rs1464772600 |
223 | V>A | No |
ClinGen gnomAD |
|
| TCGA novel | 223 | V>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1302448225 CA355849445 |
224 | G>D | No |
ClinGen gnomAD |
|
|
CA355849453 rs1403092268 |
225 | T>A | No |
ClinGen gnomAD |
|
|
rs928510292 CA89907290 |
225 | T>R | No |
ClinGen Ensembl |
|
|
rs938592708 CA89907291 |
227 | T>A | No |
ClinGen Ensembl |
|
| TCGA novel | 227 | T>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs760546808 CA2748188 |
227 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1314791158 CA355849490 |
228 | T>I | No |
ClinGen gnomAD |
|
|
CA355849511 rs1273664154 |
229 | I>M | No |
ClinGen TOPMed |
|
|
CA355849504 rs368367142 |
229 | I>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2748189 rs368367142 |
229 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2748190 COSM1421543 rs750567016 |
230 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs763097294 CA2748191 |
230 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs139818568 CA89907293 |
231 | L>V | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA355849559 rs1399980138 |
232 | M>T | No |
ClinGen TOPMed |
|
|
rs144459039 CA89907294 |
232 | M>V | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs1171853961 CA355849586 |
233 | N>I | No |
ClinGen TOPMed |
|
|
rs1411806588 CA355849601 |
234 | S>C | No |
ClinGen TOPMed |
|
|
CA89909837 rs1051120305 |
238 | T>I | No |
ClinGen Ensembl |
|
|
rs746832232 CA2748224 |
242 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2748225 rs371896958 |
242 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1199677566 CA355850396 |
243 | F>I | No |
ClinGen TOPMed |
|
|
rs748102251 CA2748227 |
245 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA89909839 rs753190955 |
248 | L>S | No |
ClinGen Ensembl |
|
|
CA2748229 rs758711603 |
250 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2748230 rs146167852 |
250 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2748231 rs139875975 |
251 | E>K | No |
ClinGen ESP ExAC |
|
|
CA89909840 rs952657126 |
255 | I>M | No |
ClinGen Ensembl |
|
|
rs761091147 CA2748233 |
257 | W>C | No |
ClinGen ExAC gnomAD |
|
|
CA2748234 rs576354653 |
259 | P>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs757780443 CA2748236 |
261 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA89909841 rs757780443 |
261 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2748237 rs182664343 |
263 | H>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA89909842 rs879095466 |
263 | H>Y | No |
ClinGen Ensembl |
|
|
CA355848353 rs1314188249 |
265 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
CA355848355 rs1403131028 |
266 | I>F | No |
ClinGen TOPMed |
|
|
CA2748238 rs749944927 |
267 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA89909843 rs749944927 |
267 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA355848385 rs1376302261 |
269 | W>R | No |
ClinGen TOPMed |
|
|
rs1321936658 CA355848397 |
270 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs997278239 CA89909972 |
272 | N>H | No |
ClinGen gnomAD |
|
|
COSM43058 CA2748257 rs750933745 |
273 | P>L | Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA355848420 rs750933745 |
273 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765918670 CA2748259 |
277 | F>C | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 277 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2748261 rs148527071 |
280 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1186598845 CA355848481 |
281 | Y>* | No |
ClinGen TOPMed |
|
|
rs1206800132 CA355848476 |
281 | Y>H | No |
ClinGen gnomAD |
|
|
CA2748262 rs780959619 |
282 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs752587119 CA2748263 |
283 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1270515322 CA355848504 |
285 | R>C | No |
ClinGen gnomAD |
|
|
rs192611052 CA2748266 |
285 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2748265 rs192611052 |
285 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs770711814 CA2748267 |
287 | L>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 290 | N>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2748268 rs780126474 |
290 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2748269 rs747048020 |
292 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA89909973 rs980098029 |
296 | L>I | No |
ClinGen TOPMed |
|
|
COSM141071 CA2748270 rs768908134 |
298 | P>S | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs1353471716 CA355848598 |
299 | Q>R | No |
ClinGen TOPMed |
|
|
CA355848604 rs1282723398 |
300 | M>L | No |
ClinGen TOPMed |
|
|
CA355848613 rs1305203863 |
301 | P>H | No |
ClinGen gnomAD |
|
|
rs776814172 CA2748271 |
301 | P>S | No |
ClinGen ExAC |
|
|
rs541483340 CA2748274 |
307 | I>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs763531128 CA2748275 |
308 | L>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA355848699 rs1293528570 |
313 | P>L | No |
ClinGen gnomAD |
|
|
CA2748278 rs147654981 |
313 | P>S | No |
ClinGen ESP ExAC gnomAD |
|
|
rs945262217 CA89909974 |
316 | I>M | No |
ClinGen TOPMed |
|
|
CA355848752 rs1186121445 |
321 | P>S | No |
ClinGen gnomAD |
|
|
rs1445625280 CA355848767 |
323 | S>F | No |
ClinGen gnomAD |
|
|
rs1162392277 CA355848780 |
325 | M>I | No |
ClinGen TOPMed |
|
|
rs756982737 CA2748302 |
328 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA2748301 rs753704231 |
328 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1415193030 CA355848814 |
329 | I>F | No |
ClinGen TOPMed |
|
|
CA2748303 rs765219640 |
329 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA2748304 rs750360040 |
330 | I>V | No |
ClinGen ExAC |
|
|
rs141298571 CA2748305 |
331 | M>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 332 | M>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs200351600 CA2748306 |
333 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2748310 rs749717895 |
337 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs1284232707 CA903968583 |
343 | F>* | No |
ClinGen TOPMed |
|
|
rs1271500275 CA355848938 |
347 | K>E | No |
ClinGen TOPMed |
|
|
CA2748312 rs774789937 |
347 | K>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA2748313 rs746386986 |
348 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA89910078 rs950997257 |
348 | R>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA355848948 rs1485375974 |
349 | K>E | No |
ClinGen gnomAD |
|
|
rs1198391239 CA355848952 |
349 | K>R | No |
ClinGen gnomAD |
|
|
CA355848961 rs1430159840 |
350 | T>I | No |
ClinGen gnomAD |
|
|
CA2748316 rs7629263 CA2748315 |
351 | D>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2748318 rs776137095 |
352 | V>E | No |
ClinGen ExAC gnomAD |
|
|
rs763859098 CA355848969 |
352 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA2748317 rs763859098 |
352 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA355849038 rs1383703578 |
361 | D>Y | No |
ClinGen TOPMed |
|
|
CA355849071 rs1480448619 |
365 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
CA89910080 rs1039794599 |
366 | M>T | No |
ClinGen Ensembl |
|
|
rs1450021505 CA355849086 |
368 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA2748323 rs766265524 |
370 | H>L | No |
ClinGen ExAC gnomAD |
|
|
CA2748324 rs752864034 |
371 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs756132824 CA2748325 |
371 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA355849116 rs757496249 |
373 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757496249 CA2748328 |
373 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA355849135 rs1481462626 |
375 | E>D | No |
ClinGen gnomAD |
|
|
rs779438137 CA2748330 |
375 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs766603901 CA2748332 |
385 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA355849273 rs1418484317 |
387 | D>Y | No |
ClinGen gnomAD |
|
|
rs775836421 CA2748333 |
388 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1346806548 CA355849340 |
391 | Y>N | No |
ClinGen gnomAD |
|
|
CA89910082 rs933095746 |
391 | Y>S | No |
ClinGen TOPMed |
|
|
rs776144488 CA2748336 |
396 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1004769428 CA89910083 |
396 | A>P | No |
ClinGen Ensembl |
|
|
CA2748337 rs188879099 |
397 | T>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1335673967 CA355849450 |
400 | G>C | No |
ClinGen TOPMed |
|
|
rs368118201 CA2748339 |
402 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA2748338 rs769388229 |
402 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
No associated diseases with P15907
No regional properties for P15907
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P15907 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.3.1 | Sialyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi cisterna membrane | The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. |
| Golgi medial cisterna | The middle Golgi cisterna (or cisternae). |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| Golgi trans cisterna | The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-galactoside alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| sialyltransferase activity | Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| humoral immune response | An immune response mediated through a body fluid. |
| N-acetylneuraminate metabolic process | The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. |
| negative regulation of chemotaxis | Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. |
| negative regulation of macrophage apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process. |
| O-glycan processing | The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. |
| positive regulation of mononuclear cell proliferation | Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. |
| protein N-linked glycosylation via asparagine | The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. |
| protein sialylation | A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein. |
| regulation of substrate adhesion-dependent cell spreading | Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading. |
| response to ethanol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
| sialylation | The covalent attachment of sialic acid to a substrate molecule. |
| viral protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q92184 | ST6GALNAC2 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Gallus gallus (Chicken) | PR |
| Q701R0 | ST6GAL2 | Beta-galactoside alpha-2,6-sialyltransferase 2 | Gallus gallus (Chicken) | PR |
| Q92182 | ST6GAL1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Gallus gallus (Chicken) | PR |
| Q9UJ37 | ST6GALNAC2 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Homo sapiens (Human) | PR |
| Q9BVH7 | ST6GALNAC5 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | Homo sapiens (Human) | PR |
| Q96JF0 | ST6GAL2 | Beta-galactoside alpha-2,6-sialyltransferase 2 | Homo sapiens (Human) | PR |
| Q9QYJ1 | St6galnac5 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | Mus musculus (Mouse) | PR |
| P70277 | St6galnac2 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Mus musculus (Mouse) | PR |
| Q64685 | St6gal1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Mus musculus (Mouse) | PR |
| P13721 | St6gal1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q9SGD2 | GALT29A | Beta-1,6-galactosyltransferase GALT29A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIHTNLKKKF | SCCVLVFLLF | AVICVWKEKK | KGSYYDSFKL | QTKEFQVLKS | LGKLAMGSDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QSVSSSSTQD | PHRGRQTLGS | LRGLAKAKPE | ASFQVWNKDS | SSKNLIPRLQ | KIWKNYLSMN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KYKVSYKGPG | PGIKFSAEAL | RCHLRDHVNV | SMVEVTDFPF | NTSEWEGYLP | KESIRTKAGP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WGRCAVVSSA | GSLKSSQLGR | EIDDHDAVLR | FNGAPTANFQ | QDVGTKTTIR | LMNSQLVTTE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KRFLKDSLYN | EGILIVWDPS | VYHSDIPKWY | QNPDYNFFNN | YKTYRKLHPN | QPFYILKPQM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PWELWDILQE | ISPEEIQPNP | PSSGMLGIII | MMTLCDQVDI | YEFLPSKRKT | DVCYYYQKFF |
| 370 | 380 | 390 | 400 | ||
| DSACTMGAYH | PLLYEKNLVK | HLNQGTDEDI | YLLGKATLPG | FRTIHC |