Q92184
Gene name |
ST6GALNAC2 (SIAT7B) |
Protein name |
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
Names |
Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase, GalNAc alpha-2,6-sialyltransferase II, ST6GalNAc II, ST6GalNAcII, Sialyltransferase 7B, SIAT7-B |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:396159 |
EC number |
2.4.3.3: Sialyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q92184
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q92184-F1 | Predicted | AlphaFoldDB |
No variants for Q92184
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q92184 | |||||
No associated diseases with Q92184
No regional properties for Q92184
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q92184 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.3.3 | Sialyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. |
| transferase activity | Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein O-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. |
| protein sialylation | A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q92182 | ST6GAL1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Gallus gallus (Chicken) | PR |
| Q701R0 | ST6GAL2 | Beta-galactoside alpha-2,6-sialyltransferase 2 | Gallus gallus (Chicken) | PR |
| P15907 | ST6GAL1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Homo sapiens (Human) | PR |
| Q96JF0 | ST6GAL2 | Beta-galactoside alpha-2,6-sialyltransferase 2 | Homo sapiens (Human) | PR |
| Q9BVH7 | ST6GALNAC5 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | Homo sapiens (Human) | PR |
| Q9UJ37 | ST6GALNAC2 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Homo sapiens (Human) | PR |
| Q64685 | St6gal1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Mus musculus (Mouse) | PR |
| Q9QYJ1 | St6galnac5 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | Mus musculus (Mouse) | PR |
| P70277 | St6galnac2 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Mus musculus (Mouse) | PR |
| P13721 | St6gal1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q9SGD2 | GALT29A | Beta-1,6-galactosyltransferase GALT29A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGSPRWKRFC | FLLLAAFTSS | LLLYGHYYAT | VDVRSGPRVV | TSLLQPELLF | LVRPDTPHPD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NSHHKELRGT | VKSREFFSQP | SSELEKPKPS | GKQPTPCPRS | VAATAKADPT | FGELFQFDIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLMWDQHFNP | ETWDRLKARR | VPYGWQGLSQ | AAVGSTLRLL | NTSSNTRLFD | RHLFPGGCIR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CAVVGNGGIL | NGSRQGRAID | AHDLVFRLNG | AITKGFEEDV | GSKVSFYGFT | VNTMKNSLIA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YEAYGFTRTP | QGKDLKYIFI | PSDARDYIML | RSAIQGSPVP | EGLDKGDEPQ | KYFGLEASAE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KFKLLHPDFL | HYLTTRFLRS | ELLDMQYGHL | YMPSTGALML | LTALHTCDQV | SAYGFITANY |
| 370 | 380 | 390 | 400 | ||
| EQFSDHYYEP | EKKPLVFYAN | HDMLLEAELW | RSLHRAGIME | LYQR |