Q9M9W8
PR
Gene name |
PLPZETA2 |
Protein name |
Phospholipase D zeta 2 |
Names |
PLDzeta2, Phospholipase D p2, AtPLDp2, Phospholipase D2 PHOX and PX-containing domain protein |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G05630 |
EC number |
3.1.4.4: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9M9W8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M9W8-F1 | Predicted | AlphaFoldDB |
68 variants for Q9M9W8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05777188 | 25 | A>T | No | 1000Genomes | |
| ENSVATH02116017 | 32 | S>Y | No | 1000Genomes | |
| tmp_3_1636259_C_T | 162 | R>C | No | 1000Genomes | |
| ENSVATH02116024 | 183 | L>F | No | 1000Genomes | |
| ENSVATH02116026 | 220 | G>E | No | 1000Genomes | |
| ENSVATH00307707 | 229 | D>N | No | 1000Genomes | |
| ENSVATH02116027 | 247 | F>I | No | 1000Genomes | |
| ENSVATH05777199 | 249 | G>R | No | 1000Genomes | |
| ENSVATH10509189 | 280 | V>M | No | 1000Genomes | |
| tmp_3_1636882_G_C | 311 | G>R | No | 1000Genomes | |
| ENSVATH00307708 | 319 | R>Q | No | 1000Genomes | |
| tmp_3_1636945_A_G | 332 | K>E | No | 1000Genomes | |
| tmp_3_1636960_G_A | 337 | A>T | No | 1000Genomes | |
| tmp_3_1636979_G_A | 343 | C>Y | No | 1000Genomes | |
| ENSVATH02116028 | 359 | T>K | No | 1000Genomes | |
| ENSVATH10509190 | 387 | S>L | No | 1000Genomes | |
| ENSVATH05777204 | 402 | L>F | No | 1000Genomes | |
| ENSVATH05777205 | 410 | P>Q | No | 1000Genomes | |
| ENSVATH05777206 | 438 | I>V | No | 1000Genomes | |
| ENSVATH05777207 | 442 | I>L | No | 1000Genomes | |
| ENSVATH02116050 | 499 | R>W | No | 1000Genomes | |
| ENSVATH02116052 | 504 | E>D | No | 1000Genomes | |
| tmp_3_1637919_G_C | 549 | W>C | No | 1000Genomes | |
| ENSVATH10509305 | 581 | P>L | No | 1000Genomes | |
| ENSVATH05777219 | 605 | E>Q | No | 1000Genomes | |
| ENSVATH02116071 | 609 | I>V | No | 1000Genomes | |
| ENSVATH02116072 | 610 | A>V | No | 1000Genomes | |
| tmp_3_1638179_C_T | 611 | A>V | No | 1000Genomes | |
| ENSVATH02116073 | 612 | A>V | No | 1000Genomes | |
| tmp_3_1638185_A_G | 613 | K>R | No | 1000Genomes | |
| ENSVATH05777220 | 621 | P>R | No | 1000Genomes | |
| tmp_3_1638262_A_G | 639 | I>V | No | 1000Genomes | |
| ENSVATH02116078 | 648 | D>N | No | 1000Genomes | |
| ENSVATH13874376 | 649 | A>E | No | 1000Genomes | |
| ENSVATH05777221 | 650 | D>N | No | 1000Genomes | |
| ENSVATH02116079 | 653 | G>S | No | 1000Genomes | |
| tmp_3_1638331_G_A | 662 | G>S | No | 1000Genomes | |
| ENSVATH02116080 | 663 | A>S | No | 1000Genomes | |
| ENSVATH02116081 | 668 | G>E | No | 1000Genomes | |
| tmp_3_1638359_C_A | 671 | S>* | No | 1000Genomes | |
| tmp_3_1638358_T_A | 671 | S>T | No | 1000Genomes | |
| ENSVATH05777222 | 677 | D>Y | No | 1000Genomes | |
| tmp_3_1638405_G_C | 686 | Q>H | No | 1000Genomes | |
| ENSVATH05777224 | 691 | S>R | No | 1000Genomes | |
| tmp_3_1638428_G_T | 694 | R>L | No | 1000Genomes | |
| ENSVATH10509307 | 726 | A>V | No | 1000Genomes | |
| ENSVATH02116083 | 730 | I>V | No | 1000Genomes | |
| ENSVATH00307712 | 736 | F>L | No | 1000Genomes | |
| ENSVATH02116085 | 744 | E>D | No | 1000Genomes | |
| tmp_3_1638689_G_A | 751 | V>I | No | 1000Genomes | |
| ENSVATH02116086 | 772 | V>M | No | 1000Genomes | |
| tmp_3_1638756_T_C | 773 | I>T | No | 1000Genomes | |
| ENSVATH05777227 | 780 | G>E | No | 1000Genomes | |
| tmp_3_1638919_C_A | 802 | R>S | No | 1000Genomes | |
| ENSVATH05777229 | 807 | E>G | No | 1000Genomes | |
| tmp_3_1639031_T_A | 839 | F>Y | No | 1000Genomes | |
| ENSVATH05777231 | 861 | R>W | No | 1000Genomes | |
| tmp_3_1639239_A_G | 883 | I>V | No | 1000Genomes | |
| ENSVATH10509309 | 907 | F>L | No | 1000Genomes | |
| tmp_3_1639330_G_A | 913 | C>Y | No | 1000Genomes | |
| ENSVATH00307713 | 924 | A>T | No | 1000Genomes | |
| ENSVATH02116105 | 927 | I>M | No | 1000Genomes | |
| ENSVATH02116110 | 955 | N>D | No | 1000Genomes | |
| ENSVATH10509399 | 974 | H>Q | No | 1000Genomes | |
| ENSVATH02116113 | 986 | T>I | No | 1000Genomes | |
| ENSVATH07954020 | 1000 | C>S | No | 1000Genomes | |
| tmp_3_1639972_A_T | 1003 | D>V | No | 1000Genomes | |
| ENSVATH02116114 | 1021 | Q>H | No | 1000Genomes |
No associated diseases with Q9M9W8
4 regional properties for Q9M9W8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phospholipase D/Transphosphatidylase | 472 - 499 | IPR001736-1 |
| domain | Phospholipase D/Transphosphatidylase | 847 - 874 | IPR001736-2 |
| domain | Pleckstrin homology domain | 215 - 345 | IPR001849 |
| domain | Phospholipase D-like domain | 720 - 894 | IPR025202 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.4 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| N-acylphosphatidylethanolamine-specific phospholipase D activity | Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). |
| phospholipase D activity | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to nitrogen starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. |
| cellular response to phosphate starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. |
| galactolipid biosynthetic process | The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine. |
| inositol lipid-mediated signaling | The series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. |
| lipid biosynthetic process | The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| phosphatidic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
| phospholipid catabolic process | The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| regulation of vesicle-mediated transport | Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. |
| response to auxin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. |
| root development | The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0V8L6 | PLD2 | Phospholipase D2 | Bos taurus (Bovine) | PR |
| O14939 | PLD2 | Phospholipase D2 | Homo sapiens (Human) | PR |
| Q13393 | PLD1 | Phospholipase D1 | Homo sapiens (Human) | PR |
| P97813 | Pld2 | Phospholipase D2 | Mus musculus (Mouse) | PR |
| Q9Z280 | Pld1 | Phospholipase D1 | Mus musculus (Mouse) | PR |
| P70498 | Pld2 | Phospholipase D2 | Rattus norvegicus (Rat) | PR |
| P70496 | Pld1 | Phospholipase D1 | Rattus norvegicus (Rat) | PR |
| P58766 | PLDALPHA3 | Phospholipase D alpha 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRZ5 | PLDZETA1 | Phospholipase D zeta 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C5Y0 | PLDDELTA | Phospholipase D delta | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTDKLLLPN | GVKSDGVIRM | TRADAAAAAA | SSSLGGGSQI | FDELPKAAIV | SVSRPDTTDF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SPLLLSYTLE | LQYKQFKWTL | QKKASQVLYL | HFALKKRLII | EELHDKQEQV | REWLHSLGIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DMQGSVVQDD | EEPDDGALPL | HYTEDSIKNR | NVPSRAALPI | IRPTIGRSET | VVDRGRTAMQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GYLSLFLGNL | DIVNSKEVCK | FLEVSRLSFA | REYGSKMKEG | YVTVKHLRDV | PGSDGVRCCL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PTHCLGFFGT | SWTKVWAVLK | PGFLALLEDP | FSGKLLDIMV | FDTLGLQGTK | ESSEQPRLAE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QVKEHNPLRF | GFKVTSGDRT | VRLRTTSSRK | VKEWVKAVDE | AGCYSPHRFG | SFAPPRGLTS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DGSQAQWFVD | GHTAFEAIAF | AIQNATSEIF | MTGWWLCPEL | YLKRPFEDHP | SLRLDALLET |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KAKQGVKIYI | LLYKEVQIAL | KINSLYSKKR | LQNIHKNVKV | LRYPDHLSSG | IYLWSHHEKI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VIVDYQVCFI | GGLDLCFGRY | DTAEHKIGDC | PPYIWPGKDY | YNPRESEPNS | WEETMKDELD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RRKYPRMPWH | DVHCALWGPP | CRDVARHFVQ | RWNHSKRNKA | PNEQTIPLLM | PHHHMVLPHY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LGTREIDIIA | AAKPEEDPDK | PVVLARHDSF | SSASPPQEIP | LLLPQETDAD | FAGRGDLKLD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SGARQDPGET | SEESDLDEAV | NDWWWQIGKQ | SDCRCQIIRS | VSQWSAGTSQ | PEDSIHRAYC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SLIQNAEHFI | YIENQFFISG | LEKEDTILNR | VLEALYRRIL | KAHEENKCFR | VVIVIPLLPG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FQGGIDDFGA | ATVRALMHWQ | YRTISREGTS | ILDNLNALLG | PKTQDYISFY | GLRSYGRLFE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DGPIATSQIY | VHSKLMIVDD | RIAVIGSSNI | NDRSLLGSRD | SEIGVVIEDK | EFVESSMNGM |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KWMAGKFSYS | LRCSLWSEHL | GLHAGEIQKI | EDPIKDATYK | DLWMATAKKN | TDIYNQVFSC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IPNEHIRSRA | ALRHNMALCK | DKLGHTTIDL | GIAPERLESC | GSDSWEILKE | TRGNLVCFPL |
| 1030 | 1040 | ||||
| QFMCDQEDLR | PGFNESEFYT | APQVFH |