Q9LRZ5
PR
Gene name |
PLDZETA1 |
Protein name |
Phospholipase D zeta 1 |
Names |
PLDzeta1, Phospholipase D p1, AtPLDp1, Phospholipase D1 PHOX and PX-containing domain protein |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G16785 |
EC number |
3.1.4.4: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LRZ5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LRZ5-F1 | Predicted | AlphaFoldDB |
41 variants for Q9LRZ5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02153872 | 12 | G>S | No | 1000Genomes | |
| ENSVATH00327825 | 21 | P>S | No | 1000Genomes | |
| tmp_3_5711937_G_A | 98 | A>T | No | 1000Genomes | |
| tmp_3_5711966_A_T | 107 | E>D | No | 1000Genomes | |
| tmp_3_5712168_G_C | 130 | V>L | No | 1000Genomes | |
| ENSVATH13932688 | 147 | A>S | No | 1000Genomes | |
| tmp_3_5712747_G_T | 211 | E>D | No | 1000Genomes | |
| tmp_3_5712775_A_G | 221 | I>V | No | 1000Genomes | |
| tmp_3_5712843_T_G | 243 | C>W | No | 1000Genomes | |
| ENSVATH05846122 | 246 | C>Y | No | 1000Genomes | |
| ENSVATH00327835 | 295 | I>V | No | 1000Genomes | |
| ENSVATH05846135 | 308 | R>Q | No | 1000Genomes | |
| ENSVATH00327838 | 327 | S>G | No | 1000Genomes | |
| ENSVATH05846154 | 416 | S>L | No | 1000Genomes | |
| ENSVATH02153885 | 425 | N>Y | No | 1000Genomes | |
| tmp_3_5714391_A_G | 429 | Q>R | No | 1000Genomes | |
| tmp_3_5714611_G_A | 454 | R>H | No | 1000Genomes | |
| tmp_3_5714897_A_T | 495 | I>F | No | 1000Genomes | |
| tmp_3_5715309_C_T | 564 | P>S | No | 1000Genomes | |
| tmp_3_5715537_A_C,G | 613 | D>A | No | 1000Genomes | |
| tmp_3_5715537_A_C,G | 613 | D>G | No | 1000Genomes | |
| ENSVATH13932694 | 622 | S>R | No | 1000Genomes | |
| tmp_3_5715606_C_T | 636 | S>L | No | 1000Genomes | |
| ENSVATH05846179 | 673 | F>L | No | 1000Genomes | |
| tmp_3_5715738_C_A | 680 | P>Q | No | 1000Genomes | |
| ENSVATH00327843 | 701 | V>L | No | 1000Genomes | |
| ENSVATH05846181 | 706 | S>T | No | 1000Genomes | |
| tmp_3_5715819_A_T,G | 707 | N>I | No | 1000Genomes | |
| tmp_3_5715819_A_T,G | 707 | N>S | No | 1000Genomes | |
| tmp_3_5715831_C_T | 711 | S>L | No | 1000Genomes | |
| tmp_3_5716185_C_A | 766 | S>Y | No | 1000Genomes | |
| ENSVATH05846186 | 771 | A>S | No | 1000Genomes | |
| ENSVATH02153899 | 802 | K>R | No | 1000Genomes | |
| tmp_3_5716871_G_A | 806 | R>H | No | 1000Genomes | |
| ENSVATH07964068 | 859 | N>S | No | 1000Genomes | |
| ENSVATH13932730 | 862 | N>T | No | 1000Genomes | |
| tmp_3_5717409_C_T | 906 | R>C | No | 1000Genomes | |
| tmp_3_5718171_G_T | 992 | A>S | No | 1000Genomes | |
| tmp_3_5718259_A_C | 995 | N>H | No | 1000Genomes | |
| tmp_3_5718523_G_A | 1040 | E>K | No | 1000Genomes | |
| ENSVATH10727287 | 1087 | E>A | No | 1000Genomes |
No associated diseases with Q9LRZ5
4 regional properties for Q9LRZ5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phospholipase D/Transphosphatidylase | 477 - 504 | IPR001736-1 |
| domain | Phospholipase D/Transphosphatidylase | 892 - 919 | IPR001736-2 |
| domain | Pleckstrin homology domain | 215 - 344 | IPR001849 |
| domain | Phospholipase D-like domain | 766 - 939 | IPR025202 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.4 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| N-acylphosphatidylethanolamine-specific phospholipase D activity | Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). |
| phospholipase D activity | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| inositol lipid-mediated signaling | The series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. |
| lipid biosynthetic process | The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| phosphatidic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
| phospholipid catabolic process | The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| root development | The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0V8L6 | PLD2 | Phospholipase D2 | Bos taurus (Bovine) | PR |
| O14939 | PLD2 | Phospholipase D2 | Homo sapiens (Human) | PR |
| Q13393 | PLD1 | Phospholipase D1 | Homo sapiens (Human) | PR |
| P97813 | Pld2 | Phospholipase D2 | Mus musculus (Mouse) | PR |
| Q9Z280 | Pld1 | Phospholipase D1 | Mus musculus (Mouse) | PR |
| P70498 | Pld2 | Phospholipase D2 | Rattus norvegicus (Rat) | PR |
| P70496 | Pld1 | Phospholipase D1 | Rattus norvegicus (Rat) | PR |
| P58766 | PLDALPHA3 | Phospholipase D alpha 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M9W8 | PLPZETA2 | Phospholipase D zeta 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C5Y0 | PLDDELTA | Phospholipase D delta | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASEQLMSPA | SGGGRYFQMQ | PEQFPSMVSS | LFSFAPAPTQ | ETNRIFEELP | KAVIVSVSRP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DAGDISPVLL | SYTIECQYKQ | FKWQLVKKAS | QVFYLHFALK | KRAFIEEIHE | KQEQVKEWLQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLGIGDHPPV | VQDEDADEVP | LHQDESAKNR | DVPSSAALPV | IRPLGRQQSI | SVRGKHAMQE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YLNHFLGNLD | IVNSREVCRF | LEVSMLSFSP | EYGPKLKEDY | IMVKHLPKFS | KSDDDSNRCC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GCCWFCCCND | NWQKVWGVLK | PGFLALLEDP | FDAKLLDIIV | FDVLPVSNGN | DGVDISLAVE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKDHNPLRHA | FKVTSGNRSI | RIRAKNSAKV | KDWVASINDA | ALRPPEGWCH | PHRFGSYAPP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RGLTDDGSQA | QWFVDGGAAF | AAIAAAIENA | KSEIFICGWW | VCPELYLRRP | FDPHTSSRLD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NLLENKAKQG | VQIYILIYKE | VALALKINSV | YSKRRLLGIH | ENVRVLRYPD | HFSSGVYLWS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HHEKLVIVDN | QVCFIGGLDL | CFGRYDTFEH | KVGDNPSVTW | PGKDYYNPRE | SEPNTWEDAL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KDELERKKHP | RMPWHDVHCA | LWGPPCRDVA | RHFVQRWNYA | KRNKAPYEDS | IPLLMPQHHM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VIPHYMGRQE | ESDIESKKEE | DSIRGIRRDD | SFSSRSSLQD | IPLLLPHEPV | DQDGSSGGHK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ENGTNNRNGP | FSFRKSKIEP | VDGDTPMRGF | VDDRNGLDLP | VAKRGSNAID | SEWWETQDHD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YQVGSPDETG | QVGPRTSCRC | QIIRSVSQWS | AGTSQVEESI | HSAYRSLIDK | AEHFIYIENQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FFISGLSGDD | TVKNRVLEAL | YKRILRAHNE | KKIFRVVVVI | PLLPGFQGGI | DDSGAASVRA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IMHWQYRTIY | RGHNSILTNL | YNTIGVKAHD | YISFYGLRAY | GKLSEDGPVA | TSQVYVHSKI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| MIVDDRAALI | GSANINDRSL | LGSRDSEIGV | LIEDTELVDS | RMAGKPWKAG | KFSSSLRLSL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| WSEHLGLRTG | EIDQIIDPVS | DSTYKEIWMA | TAKTNTMIYQ | DVFSCVPNDL | IHSRMAFRQS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LSYWKEKLGH | TTIDLGIAPE | KLESYHNGDI | KRSDPMDRLK | AIKGHLVSFP | LDFMCKEDLR |
| 1090 | |||||
| PVFNESEYYA | SPQVFH |