P58766
PR
Gene name |
PLDALPHA3 |
Protein name |
Phospholipase D alpha 3 |
Names |
AtPLDalpha3, PLD alpha 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G25370 |
EC number |
3.1.4.4: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P58766
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P58766-F1 | Predicted | AlphaFoldDB |
86 variants for P58766
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00647315 | 28 | N>I | No | 1000Genomes | |
| ENSVATH11041127 | 39 | G>A | No | 1000Genomes | |
| ENSVATH03121579 | 55 | S>N | No | 1000Genomes | |
| ENSVATH03121578 | 56 | L>F | No | 1000Genomes | |
| ENSVATH03121576 | 63 | A>V | No | 1000Genomes | |
| ENSVATH07041494 | 76 | M>T | No | 1000Genomes | |
| ENSVATH07041492 | 93 | H>Y | No | 1000Genomes | |
| ENSVATH03121574 | 99 | I>V | No | 1000Genomes | |
| tmp_5_8807150_C_G | 105 | D>H | No | 1000Genomes | |
| ENSVATH00647310 | 109 | S>G | No | 1000Genomes | |
| ENSVATH11041125 | 119 | P>A | No | 1000Genomes | |
| tmp_5_8807086_C_T | 126 | G>E | No | 1000Genomes | |
| ENSVATH03121570 | 127 | Q>P | No | 1000Genomes | |
| tmp_5_8807054_C_T | 137 | D>N | No | 1000Genomes | |
| ENSVATH11041064 | 146 | G>R | No | 1000Genomes | |
| ENSVATH07041491 | 149 | L>I | No | 1000Genomes | |
| ENSVATH07041490 | 157 | H>N | No | 1000Genomes | |
| ENSVATH11041063 | 162 | V>A | No | 1000Genomes | |
| tmp_5_8806931_T_C | 178 | N>D | No | 1000Genomes | |
| ENSVATH03121567 | 244 | V>M | No | 1000Genomes | |
| ENSVATH00647300 | 251 | K>N | No | 1000Genomes | |
| ENSVATH11041057 | 256 | G>R | No | 1000Genomes | |
| tmp_5_8806650_T_A | 271 | E>D | No | 1000Genomes | |
| ENSVATH07041483 | 271 | E>Q | No | 1000Genomes | |
| ENSVATH11041056 | 279 | V>A | No | 1000Genomes | |
| ENSVATH11041056 | 279 | V>E | No | 1000Genomes | |
| ENSVATH03121562 | 292 | D>E | No | 1000Genomes | |
| ENSVATH07041482 | 303 | Y>S | No | 1000Genomes | |
| ENSVATH11040953 | 312 | R>H | No | 1000Genomes | |
| tmp_5_8806520_G_A | 315 | L>F | No | 1000Genomes | |
| tmp_5_8806510_C_T | 318 | R>Q | No | 1000Genomes | |
| tmp_5_8806498_T_C | 322 | N>S | No | 1000Genomes | |
| tmp_5_8806454_T_C | 337 | T>A | No | 1000Genomes | |
| tmp_5_8806451_G_T | 338 | H>N | No | 1000Genomes | |
| tmp_5_8806439_T_A | 342 | T>S | No | 1000Genomes | |
| ENSVATH03121561 | 347 | S>G | No | 1000Genomes | |
| tmp_5_8806423_C_T | 347 | S>N | No | 1000Genomes | |
| ENSVATH07041480 | 349 | V>M | No | 1000Genomes | |
| ENSVATH07041478 | 356 | R>G | No | 1000Genomes | |
| ENSVATH14190568 | 356 | R>T | No | 1000Genomes | |
| ENSVATH07041476 | 382 | T>A | No | 1000Genomes | |
| tmp_5_8806272_A_C | 397 | D>E | No | 1000Genomes | |
| tmp_5_8806267_G_A | 399 | A>V | No | 1000Genomes | |
| tmp_5_8806258_T_A | 402 | K>I | No | 1000Genomes | |
| tmp_5_8806255_T_A | 403 | K>M | No | 1000Genomes | |
| tmp_5_8806225_A_C | 413 | I>S | No | 1000Genomes | |
| ENSVATH03121553 | 425 | V>L | No | 1000Genomes | |
| ENSVATH11040946 | 438 | S>C | No | 1000Genomes | |
| ENSVATH07041444 | 444 | I>L | No | 1000Genomes | |
| tmp_5_8805728_C_T | 446 | M>I | No | 1000Genomes | |
| tmp_5_8805718_C_T | 450 | A>T | No | 1000Genomes | |
| tmp_5_8805702_G_A | 455 | P>L | No | 1000Genomes | |
| tmp_5_8805682_G_A | 462 | P>S | No | 1000Genomes | |
| tmp_5_8805679_C_T | 463 | D>N | No | 1000Genomes | |
| ENSVATH07041442 | 479 | G>C | No | 1000Genomes | |
| ENSVATH11040864 | 492 | A>T | No | 1000Genomes | |
| ENSVATH07041439 | 503 | V>M | No | 1000Genomes | |
| tmp_5_8805508_T_G | 520 | K>Q | No | 1000Genomes | |
| tmp_5_8805465_G_C | 534 | S>C | No | 1000Genomes | |
| ENSVATH07041438 | 538 | N>T | No | 1000Genomes | |
| ENSVATH07041436 | 543 | N>D | No | 1000Genomes | |
| tmp_5_8805432_T_A | 545 | N>I | No | 1000Genomes | |
| ENSVATH07041433 | 561 | I>L | No | 1000Genomes | |
| ENSVATH07041433 | 561 | I>V | No | 1000Genomes | |
| ENSVATH07041430 | 567 | A>T | No | 1000Genomes | |
| ENSVATH03121527 | 569 | E>K | No | 1000Genomes | |
| tmp_5_8805343_T_C | 575 | I>V | No | 1000Genomes | |
| ENSVATH07041428 | 584 | K>R | No | 1000Genomes | |
| tmp_5_8805310_C_T | 586 | G>S | No | 1000Genomes | |
| ENSVATH00647288 | 586 | G>V | No | 1000Genomes | |
| tmp_5_8805306_G_A | 587 | S>F | No | 1000Genomes | |
| ENSVATH11040863 | 595 | D>E | No | 1000Genomes | |
| ENSVATH07041426 | 622 | R>K | No | 1000Genomes | |
| tmp_5_8805128_T_G | 646 | K>N | No | 1000Genomes | |
| tmp_5_8805126_G_T | 647 | P>Q | No | 1000Genomes | |
| tmp_5_8805114_G_C | 651 | S>C | No | 1000Genomes | |
| ENSVATH07041421 | 652 | D>N | No | 1000Genomes | |
| tmp_5_8805106_C_A | 654 | A>S | No | 1000Genomes | |
| ENSVATH03121524 | 655 | R>K | No | 1000Genomes | |
| ENSVATH00647285 | 658 | E>K | No | 1000Genomes | |
| ENSVATH07041420 | 670 | M>I | No | 1000Genomes | |
| tmp_5_8804598_G_C | 702 | A>G | No | 1000Genomes | |
| tmp_5_8804571_G_A | 711 | T>I | No | 1000Genomes | |
| ENSVATH03121504 | 713 | N>D | No | 1000Genomes | |
| tmp_5_8804316_G_A | 796 | T>I | No | 1000Genomes | |
| tmp_5_8804244_G_T | 820 | S>Y | No | 1000Genomes |
No associated diseases with P58766
4 regional properties for P58766
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1 - 134 | IPR000008 |
| domain | Phospholipase D/Transphosphatidylase | 334 - 371 | IPR001736-1 |
| domain | Phospholipase D/Transphosphatidylase | 662 - 689 | IPR001736-2 |
| domain | Phospholipase D, C-terminal | 737 - 810 | IPR024632 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.4 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| N-acylphosphatidylethanolamine-specific phospholipase D activity | Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). |
| phospholipase D activity | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| membrane lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. |
| phosphatidylcholine metabolic process | The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. |
| phospholipid catabolic process | The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| response to abscisic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. |
| response to salt stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. |
| response to water deprivation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0V8L6 | PLD2 | Phospholipase D2 | Bos taurus (Bovine) | PR |
| O14939 | PLD2 | Phospholipase D2 | Homo sapiens (Human) | PR |
| Q13393 | PLD1 | Phospholipase D1 | Homo sapiens (Human) | PR |
| P97813 | Pld2 | Phospholipase D2 | Mus musculus (Mouse) | PR |
| Q9Z280 | Pld1 | Phospholipase D1 | Mus musculus (Mouse) | PR |
| P70498 | Pld2 | Phospholipase D2 | Rattus norvegicus (Rat) | PR |
| P70496 | Pld1 | Phospholipase D1 | Rattus norvegicus (Rat) | PR |
| Q9LRZ5 | PLDZETA1 | Phospholipase D zeta 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M9W8 | PLPZETA2 | Phospholipase D zeta 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C5Y0 | PLDDELTA | Phospholipase D delta | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTEQLLLHGT | LEVKIYRIDK | LHQRSRFNLC | GKGNKEPTGK | KTQSQIKRLT | DSCTSLFGGH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LYATIDLDRS | RVARTMMRRH | PKWLQSFHVY | TAHSISKIIF | TVKEDEPVSA | SLIGRAYLPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TEVITGQPID | RWLDILDENR | RPIQGGSKLH | VRVKFTHVTQ | DVNWNKGIIL | PSFNGVPNAY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FNQREGCKVT | LYQDAHVLNE | YPDVTLTGGQ | VIYKHHRCWE | EIFDAIWEAK | HLIYIAGWSV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NTDVTLVRDP | KRTRPGGDLK | LGELLKKKAE | ENVTVLMLVW | DDRTSHEVFK | RDGLMMTHDQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ETYDYFKNTK | VRCVLCPRNP | DNGDSIVQGF | EVATMFTHHQ | KTIVVDSEVD | GSLTKRRIVS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FLGGIDLCDG | RYDTVEHPLF | GTLNSVHAND | FHQPNFDGAS | IKKGGPREPW | HDIHCKLDGP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AAWDVLYNFE | QRWMKQGSGR | RYLISMAQLA | EITVPPLPIV | QPDNEEGWTV | QVFRSIDDGA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VEGFPEDPRE | AASIGLISGK | DNVIERSIQD | AYVNAIRRAK | NFIYIENQYF | LGSSFGWNSR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DINLNEINAL | QLIPKEISLK | IVSKIEAGER | FSVYIVIPLW | PEGKPGSASV | QAILDWQRRT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MEMMYTDIII | ALRKKGLDAN | PRDYLTFFCL | GNREKGKVGE | YLPPEKPEAN | SDYARAQESR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RFMIYVHSKM | MIVDDEYIII | GSANINQRSM | DGGRDTEIAM | GAYQPSHLLS | TNNMRPVGQI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FSFRISLWLE | HLRVTTNAFQ | CPESEECIRM | VNATADELWG | LYSAQEYPRN | DDLPGHLLSY |
| 790 | 800 | 810 | |||
| PISIGSNGEV | TNLAGTEFFP | DTNAKVVGEK | SNYLPPILTS |