P70496

PR
Gene name
Pld1
Protein name
Phospholipase D1
Names
PLD 1, rPLD1, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25096
EC number
3.1.4.4: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P70496

Entry ID Method Resolution Chain Position Source
AF-P70496-F1 Predicted AlphaFoldDB

No variants for P70496

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P70496

No associated diseases with P70496

5 regional properties for P70496

Type Name Position InterPro Accession
domain Phox homology 79 - 212 IPR001683
domain Phospholipase D/Transphosphatidylase 459 - 486 IPR001736-1
domain Phospholipase D/Transphosphatidylase 891 - 918 IPR001736-2
domain Pleckstrin homology domain 219 - 330 IPR001849
domain Phospholipase D-like domain 768 - 936 IPR025202

Functions

Description
EC Number 3.1.4.4 Phosphoric diester hydrolases
Subcellular Localization
  • Cytoplasm, perinuclear region
  • Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side
  • Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side
  • Late endosome membrane ; Lipid-anchor ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

14 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cholinergic synapse A synapse that uses acetylcholine as a neurotransmitter.
endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
endosome A vacuole to which materials ingested by endocytosis are delivered.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi cisterna Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
late endosome membrane The lipid bilayer surrounding a late endosome.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.

3 GO annotations of molecular function

Name Definition
N-acylphosphatidylethanolamine-specific phospholipase D activity Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phospholipase D activity Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.

11 GO annotations of biological process

Name Definition
defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
inositol lipid-mediated signaling The series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids.
phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.
phospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
regulation of microvillus assembly A process that modulates the formation of a microvillus.
regulation of synaptic vesicle cycle Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle.
regulation of vesicle-mediated transport Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
response to peptide hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0V8L6 PLD2 Phospholipase D2 Bos taurus (Bovine) PR
O14939 PLD2 Phospholipase D2 Homo sapiens (Human) PR
Q13393 PLD1 Phospholipase D1 Homo sapiens (Human) PR
P97813 Pld2 Phospholipase D2 Mus musculus (Mouse) PR
Q9Z280 Pld1 Phospholipase D1 Mus musculus (Mouse) PR
P70498 Pld2 Phospholipase D2 Rattus norvegicus (Rat) PR
P58766 PLDALPHA3 Phospholipase D alpha 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M9W8 PLPZETA2 Phospholipase D zeta 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRZ5 PLDZETA1 Phospholipase D zeta 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C5Y0 PLDDELTA Phospholipase D delta Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSLRSEARVN TSTLQKIAAD MSNLIENLDT RELHFEGEEV EYDASPGDPT AQEACIPFSS
70 80 90 100 110 120
IYNTQGFKEP NIQIYLSGCP VKAQVLEVER FTSTSRMPSV NLYTIELTHG EFTWQVKRKF
130 140 150 160 170 180
KHFQEFHREL LKYKAFIRIP IPTKRHTFRR QNVKEEPREM PSLPRSSENA IQEEQFFGRR
190 200 210 220 230 240
KQLEDYLTKI LKMPMYRNYH ATTEFLDVSQ LSFIHDLGPK GLEGMIMKRS GGHRIPGVNC
250 260 270 280 290 300
CGHGRACYRW SKRWLIVKDS FLLYMKPDSG AIAFVLLVDK EFRIKVGKKE TETKYGLRID
310 320 330 340 350 360
NLSRTLILKC NSYRHARWWG GAIEEFIQKH GTDFLKDHRF GSYAAVHENI LAKWYVNAKG
370 380 390 400 410 420
YFEDIANAME GATEEIFITD WWLSPEIFLK RPVVEGNRWR LDCILKRKAQ QGVRIFIMLY
430 440 450 460 470 480
KEVELALGIN SEYTKRTLMR LHPNIKVMRH PDHVSSSVYL WAHHEKLVII DQSVAFVGGI
490 500 510 520 530 540
DLAYGRWDDN EHRLTDVGSV KRVTSGQSLG SLTAASVESM ESLSLKDKHQ SHKNEPVLKS
550 560 570 580 590 600
VNDTDMKLKG IGKSRKFSKF SLYRQLHRRN LHNSDSISSV DSASSYFNHY RSHQNLIHGI
610 620 630 640 650 660
KPHLKLFRPS SESEQGLTRH SADTGSIRSV QTGVGELHGE TRFWHGKDYC NFVFKDWVQL
670 680 690 700 710 720
DKPFADFIDR YSTPRMPWHD IGSVVHGKAA RDVARHFIQR WNFTKIMKPK YRSLSYPFLL
730 740 750 760 770 780
PKSQATAHEL RYQVPGAVHA KAQLLRSAAD WSAGIKHHEE SIHAAYTHVI ENSKHYIYIE
790 800 810 820 830 840
NQFFISCADD KVVFNKVGNA IAQRILKAHR EGQRYRVYIV IPLLPGFEGD ISTGGGNALQ
850 860 870 880 890 900
AIMHFNYRTM CRGESSILEQ LKPELGNKWI NYISFCGLRT HAELEGNLVT ELIYVHSKLL
910 920 930 940 950 960
IADDNTVIIG SANINDRSML GKRDSEMAVI VQDTETVPSV MDGKEYQAGR FAQGLRLECF
970 980 990 1000 1010 1020
RLVLGYLSDP SEDIQDPVSD KFFKEIWVST AARNATIYDK VFRCLPNDEV HNLIQLRDFI
1030 1040 1050 1060 1070
NKPILAKEDR LRAEEELRKI RGFLVQFPFY FLSEENLLPS VGTKEAIVPM EVWT