Q9C5Y0
PR
Gene name |
PLDDELTA |
Protein name |
Phospholipase D delta |
Names |
AtPLDdelta, PLD delta |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G35790 |
EC number |
3.1.4.4: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9C5Y0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9C5Y0-F1 | Predicted | AlphaFoldDB |
36 variants for Q9C5Y0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH06830881 | 59 | D>G | No | 1000Genomes | |
| ENSVATH00554111 | 60 | K>R | No | 1000Genomes | |
| tmp_4_16959682_T_C | 65 | D>G | No | 1000Genomes | |
| ENSVATH00554110 | 66 | K>R | No | 1000Genomes | |
| tmp_4_16959667_C_T | 70 | S>N | No | 1000Genomes | |
| ENSVATH12417107 | 138 | K>Q | No | 1000Genomes | |
| ENSVATH06830879 | 221 | D>A | No | 1000Genomes | |
| tmp_4_16959208_G_A | 223 | T>M | No | 1000Genomes | |
| ENSVATH02962184 | 226 | A>E | No | 1000Genomes | |
| ENSVATH06830878 | 236 | E>Q | No | 1000Genomes | |
| ENSVATH02962181 | 266 | I>V | No | 1000Genomes | |
| ENSVATH06830877 | 273 | K>E | No | 1000Genomes | |
| ENSVATH02962180 | 274 | V>F | No | 1000Genomes | |
| ENSVATH06830875 | 277 | D>A | No | 1000Genomes | |
| ENSVATH06830876 | 277 | D>H | No | 1000Genomes | |
| ENSVATH06830876 | 277 | D>Y | No | 1000Genomes | |
| ENSVATH06830874 | 278 | K>E | No | 1000Genomes | |
| ENSVATH06830873 | 278 | K>N | No | 1000Genomes | |
| tmp_4_16958641_A_G | 359 | S>P | No | 1000Genomes | |
| tmp_4_16958343_C_T | 366 | V>I | No | 1000Genomes | |
| ENSVATH00554105 | 504 | K>T | No | 1000Genomes | |
| ENSVATH06830856 | 508 | S>T | No | 1000Genomes | |
| ENSVATH06830854 | 513 | D>E | No | 1000Genomes | |
| tmp_4_16957788_T_C | 521 | K>E | No | 1000Genomes | |
| ENSVATH00554103 | 542 | K>R | No | 1000Genomes | |
| tmp_4_16957604_C_A | 552 | E>D | No | 1000Genomes | |
| ENSVATH12417010 | 605 | A>G | No | 1000Genomes | |
| tmp_4_16957041_T_G | 624 | K>Q | No | 1000Genomes | |
| tmp_4_16957019_A_C | 631 | V>G | No | 1000Genomes | |
| ENSVATH12417007 | 678 | L>V | No | 1000Genomes | |
| ENSVATH06830844 | 691 | Q>E | No | 1000Genomes | |
| ENSVATH00554099 | 698 | A>G | No | 1000Genomes | |
| tmp_4_16956436_T_G | 741 | M>L | No | 1000Genomes | |
| tmp_4_16956028_T_C | 785 | K>E | No | 1000Genomes | |
| ENSVATH12416988 | 785 | K>T | No | 1000Genomes | |
| ENSVATH00554096 | 819 | S>L | No | 1000Genomes |
No associated diseases with Q9C5Y0
4 regional properties for Q9C5Y0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1 - 156 | IPR000008 |
| domain | Phospholipase D/Transphosphatidylase | 368 - 403 | IPR001736-1 |
| domain | Phospholipase D/Transphosphatidylase | 713 - 740 | IPR001736-2 |
| domain | Phospholipase D, C-terminal | 788 - 857 | IPR024632 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.4 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| plant cell papilla | A cell projection that is a short, rounded projection from a plant epidermal cell. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| N-acylphosphatidylethanolamine-specific phospholipase D activity | Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). |
| phospholipase D activity | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidic acid metabolic process | The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
| phosphatidylcholine metabolic process | The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. |
| phospholipid catabolic process | The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| positive regulation of abscisic acid-activated signaling pathway | Any process that activates or increases the frequency, rate or extent of abscisic acid (ABA) signaling. |
| programmed cell death | A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. |
| regulation of stomatal closure | Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange. |
| response to cold | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0V8L6 | PLD2 | Phospholipase D2 | Bos taurus (Bovine) | PR |
| O14939 | PLD2 | Phospholipase D2 | Homo sapiens (Human) | PR |
| Q13393 | PLD1 | Phospholipase D1 | Homo sapiens (Human) | PR |
| P97813 | Pld2 | Phospholipase D2 | Mus musculus (Mouse) | PR |
| Q9Z280 | Pld1 | Phospholipase D1 | Mus musculus (Mouse) | PR |
| P70496 | Pld1 | Phospholipase D1 | Rattus norvegicus (Rat) | PR |
| P70498 | Pld2 | Phospholipase D2 | Rattus norvegicus (Rat) | PR |
| P58766 | PLDALPHA3 | Phospholipase D alpha 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRZ5 | PLDZETA1 | Phospholipase D zeta 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M9W8 | PLPZETA2 | Phospholipase D zeta 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEKVSEDVM | LLHGDLDLKI | VKARRLPNMD | MFSEHLRRLF | TACNACARPT | DTDDVDPRDK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GEFGDKNIRS | HRKVITSDPY | VTVVVPQATL | ARTRVLKNSQ | EPLWDEKFNI | SIAHPFAYLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FQVKDDDVFG | AQIIGTAKIP | VRDIASGERI | SGWFPVLGAS | GKPPKAETAI | FIDMKFTPFD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QIHSYRCGIA | GDPERRGVRR | TYFPVRKGSQ | VRLYQDAHVM | DGTLPAIGLD | NGKVYEHGKC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WEDICYAISE | AHHMIYIVGW | SIFHKIKLVR | ETKVPRDKDM | TLGELLKYKS | QEGVRVLLLV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WDDKTSHDKF | GIKTPGVMGT | HDEETRKFFK | HSSVICVLSP | RYASSKLGLF | KQQASPSSSI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YIMTVVGTLF | THHQKCVLVD | TQAVGNNRKV | TAFIGGLDLC | DGRYDTPEHR | ILHDLDTVFK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DDFHNPTFPA | GTKAPRQPWH | DLHCRIDGPA | AYDVLINFEQ | RWRKATRWKE | FSLRLKGKTH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WQDDALIRIG | RISWILSPVF | KFLKDGTSII | PEDDPCVWVS | KEDDPENWHV | QIFRSIDSGS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VKGFPKYEDE | AEAQHLECAK | RLVVDKSIQT | AYIQTIRSAQ | HFIYIENQYF | LGSSYAWPSY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RDAGADNLIP | MELALKIVSK | IRAKERFAVY | VVIPLWPEGD | PKSGPVQEIL | YWQSQTMQMM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YDVIAKELKA | VQSDAHPLDY | LNFYCLGKRE | QLPDDMPATN | GSVVSDSYNF | QRFMIYVHAK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GMIVDDEYVL | MGSANINQRS | MAGTKDTEIA | MGAYQPNHTW | AHKGRHPRGQ | VYGYRMSLWA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EHLGKTGDEF | VEPSDLECLK | KVNTISEENW | KRFIDPKFSE | LQGHLIKYPL | QVDVDGKVSP |
| 850 | 860 | ||||
| LPDYETFPDV | GGKIIGAHSM | ALPDTLTT |