Q0V8L6

PR
Gene name
PLD2
Protein name
Phospholipase D2
Names
PLD 2, Choline phosphatase 2, Phosphatidylcholine-hydrolyzing phospholipase D2
Species
Bos taurus (Bovine)
KEGG Pathway
bta:522159
EC number
3.1.4.4: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0V8L6

Entry ID Method Resolution Chain Position Source
AF-Q0V8L6-F1 Predicted AlphaFoldDB

No variants for Q0V8L6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0V8L6

No associated diseases with Q0V8L6

4 regional properties for Q0V8L6

Type Name Position InterPro Accession
domain Phox homology 64 - 195 IPR001683
domain Phospholipase D/Transphosphatidylase 437 - 464 IPR001736-1
domain Phospholipase D/Transphosphatidylase 751 - 778 IPR001736-2
domain Phospholipase D-like domain 627 - 795 IPR025202

Functions

Description
EC Number 3.1.4.4 Phosphoric diester hydrolases
Subcellular Localization
  • Cell membrane ; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
N-acylphosphatidylethanolamine-specific phospholipase D activity Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phospholipase D activity Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.

4 GO annotations of biological process

Name Definition
inositol lipid-mediated signaling The series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids.
phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
phospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
regulation of vesicle-mediated transport Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q13393 PLD1 Phospholipase D1 Homo sapiens (Human) PR
O14939 PLD2 Phospholipase D2 Homo sapiens (Human) PR
Q9Z280 Pld1 Phospholipase D1 Mus musculus (Mouse) PR
P97813 Pld2 Phospholipase D2 Mus musculus (Mouse) PR
P70496 Pld1 Phospholipase D1 Rattus norvegicus (Rat) PR
P70498 Pld2 Phospholipase D2 Rattus norvegicus (Rat) PR
P58766 PLDALPHA3 Phospholipase D alpha 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M9W8 PLPZETA2 Phospholipase D zeta 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRZ5 PLDZETA1 Phospholipase D zeta 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C5Y0 PLDDELTA Phospholipase D delta Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAATPQSLFP SGDDLDSSQL QMEPDEVDTL KEGEDPADRM HPFLAIYHLQ PLKLHPLVFA
70 80 90 100 110 120
PGVPVIAQVV GTERYTSGSK VGTCTLYSVR LTHGDFTWTT KKKFRHFQEL HRDLLRHKVF
130 140 150 160 170 180
MSLLPLARFA VASSPAPEGD SREIPSLPRA GPEGSSRRTA SKQKYLENYL NRLLTMSFYR
190 200 210 220 230 240
NYHAMTEFLE VSQLSFIPDL GCKGLEGVIR KRSGGHRVPG LTCCGRDQVC YRWSKRWLVV
250 260 270 280 290 300
KDSFLLYMCL ETGAISFVQL FDPGFKVQVG KRSTEARYGV RVDTSHRSLI LKCSSYRQAR
310 320 330 340 350 360
WWAQEITELA QGPGRDFIQL HRHDSYAPPR PGTLARWFVN GAGYFAAVAD AILRAQEEIF
370 380 390 400 410 420
ITDWWLSPEI YLKRPAHSDD WRLDIMLKKK AEEGVHVSVL LFKEVELALA INSGYSKKAL
430 440 450 460 470 480
MLLHPNIKVM RHPDQVTLWA HHEKLLVVDQ VVAFLGGLDL AYGRWDDLHY RLTDLGDSSE
490 500 510 520 530 540
SAAPQPPTSC SDLPATPDLT HNQLFWLGKD YSNLITKDWV QLDRPFDDFI DRETMPRMPW
550 560 570 580 590 600
RDIGVVVHGS PARDLARHFI QRWNFTKTTK TKYKIPIYPY LLPKSTSTAN QLPFTLSGGQ
610 620 630 640 650 660
CATVQVLRSV DRWSAGTLEN SILNAYLHTI RESQHFLYIE NQFFISCSDG RTVLNKVGDE
670 680 690 700 710 720
IVDRILKAHK QGQCFRVYVL LPLLPGFEGD ISTGGGNSIQ AILHFTYRTL CRGEYSILHR
730 740 750 760 770 780
LKAAMGTEWR NYISVCGLRT HGELGGHPVS ELIYIHSKML IADDRTVIIG SANINDRSLL
790 800 810 820 830 840
GKRDSELAVL IEDTEMEPSL MNGVEYQAGR FALSLRKHCF SVILGAAARP HLDLRDPVCD
850 860 870 880 890 900
AFFQLWQDTA ESNANIYEQI FRCLPSNATR SLRALREYVV VEPLATVSPP LARSELNQVQ
910 920 930
GHLVHFPLKF LEDEYLLPSL GSKEGVMPLE VWT