Q9M0G4
Gene name |
TYRDC |
Protein name |
Tyrosine decarboxylase 2 |
Names |
AtTYDC, TyrDC-like protein |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G28680 |
EC number |
4.1.1.25: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9M0G4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M0G4-F1 | Predicted | AlphaFoldDB |
45 variants for Q9M0G4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_14155267_T_C | 7 | M>T | No | 1000Genomes | |
| ENSVATH14306882 | 12 | F>C | No | 1000Genomes | |
| tmp_4_14155309_G_C | 21 | G>A | No | 1000Genomes | |
| ENSVATH02935670 | 26 | N>K | No | 1000Genomes | |
| ENSVATH06792058 | 30 | H>Y | No | 1000Genomes | |
| ENSVATH06792059 | 35 | G>R | No | 1000Genomes | |
| tmp_4_14155378_A_G | 44 | N>S | No | 1000Genomes | |
| ENSVATH06792060 | 47 | G>E | No | 1000Genomes | |
| tmp_4_14155410_G_A | 55 | V>I | No | 1000Genomes | |
| ENSVATH12279830 | 59 | P>L | No | 1000Genomes | |
| tmp_4_14155460_A_G | 71 | I>M | No | 1000Genomes | |
| tmp_4_14155504_C_T | 86 | S>L | No | 1000Genomes | |
| ENSVATH06792061 | 89 | D>E | No | 1000Genomes | |
| tmp_4_14155512_G_A | 89 | D>N | No | 1000Genomes | |
| tmp_4_14155678_G_C | 105 | L>F | No | 1000Genomes | |
| ENSVATH06792063 | 133 | H>N | No | 1000Genomes | |
| tmp_4_14155895_A_T | 139 | Y>F | No | 1000Genomes | |
| tmp_4_14156018_T_C | 180 | I>T | No | 1000Genomes | |
| ENSVATH06792064 | 191 | L>F | No | 1000Genomes | |
| tmp_4_14156361_G_A | 199 | G>E | No | 1000Genomes | |
| tmp_4_14156402_G_A | 213 | V>M | No | 1000Genomes | |
| tmp_4_14156471_C_T | 236 | L>F | No | 1000Genomes | |
| ENSVATH00543041 | 270 | S>P | No | 1000Genomes | |
| ENSVATH06792080 | 282 | E>G | No | 1000Genomes | |
| tmp_4_14156684_C_T | 283 | A>V | No | 1000Genomes | |
| tmp_4_14156692_C_G | 286 | H>D | No | 1000Genomes | |
| tmp_4_14156701_G_T | 289 | A>S | No | 1000Genomes | |
| ENSVATH12279888 | 298 | C>G | No | 1000Genomes | |
| tmp_4_14156897_T_C | 313 | V>A | No | 1000Genomes | |
| tmp_4_14157434_T_C | 381 | I>T | No | 1000Genomes | |
| ENSVATH06792095 | 382 | D>Y | No | 1000Genomes | |
| ENSVATH02935707 | 400 | T>A | No | 1000Genomes | |
| ENSVATH00543051 | 455 | S>R | No | 1000Genomes | |
| ENSVATH06792108 | 458 | V>I | No | 1000Genomes | |
| ENSVATH00543052 | 461 | T>S | No | 1000Genomes | |
| tmp_4_14158170_T_C | 463 | Y>H | No | 1000Genomes | |
| ENSVATH14306939 | 473 | P>A | No | 1000Genomes | |
| tmp_4_14158214_T_A | 477 | D>E | No | 1000Genomes | |
| tmp_4_14158221_C_A | 480 | Q>K | No | 1000Genomes | |
| ENSVATH02935717 | 481 | C>S | No | 1000Genomes | |
| tmp_4_14158242_G_A | 487 | E>K | No | 1000Genomes | |
| tmp_4_14158432_A_T | 508 | K>N | No | 1000Genomes | |
| ENSVATH06792116 | 510 | V>I | No | 1000Genomes | |
| tmp_4_14158494_G_T | 529 | W>L | No | 1000Genomes | |
| ENSVATH06792119 | 543 | D>G | No | 1000Genomes |
No associated diseases with Q9M0G4
No regional properties for Q9M0G4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9M0G4 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.25 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| carboxy-lyase activity | Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| tyrosine decarboxylase activity | Catalysis of the reaction: L-tyrosine = tyramine + CO2. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular amino acid metabolic process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5EA83 | HDC | Histidine decarboxylase | Bos taurus (Bovine) | PR |
| P05031 | Ddc | Aromatic-L-amino-acid decarboxylase | Drosophila melanogaster (Fruit fly) | PR |
| P18486 | amd | 3,4-dihydroxyphenylacetaldehyde synthase | Drosophila melanogaster (Fruit fly) | PR |
| P19113 | HDC | Histidine decarboxylase | Homo sapiens (Human) | PR |
| P23738 | Hdc | Histidine decarboxylase | Mus musculus (Mouse) | PR |
| P16453 | Hdc | Histidine decarboxylase | Rattus norvegicus (Rat) | PR |
| Q95ZS2 | tdc-1 | Tyrosine decarboxylase | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFKPQHMYDR | EFGTGNGYSN | GNGYTNGNGH | TNGNGNYNGN | GHVNGNGKAN | GAKVVKMKPM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DSELLREQGH | IMVDFIADYY | KNLQDSPQDF | PVLSQVQPGY | LRDMLPDSAP | ERPESLKELL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DDVSKKIMPG | ITHWQSPSYF | AYYASSTSVA | GFLGEMLNAG | LSVVGFTWLT | SPAATELEII |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLDWLAKLLQ | LPDHFLSTGN | GGGVIQGTGC | EAVLVVVLAA | RDRILKKVGK | TLLPQLVVYG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SDQTHSSFRK | ACLIGGIHEE | NIRLLKTDSS | TNYGMPPESL | EEAISHDLAK | GFIPFFICAT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VGTTSSAAVD | PLVPLGNIAK | KYGIWLHVDA | AYAGNACICP | EYRKFIDGIE | NADSFNMNAH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KWLFANQTCS | PLWVKDRYSL | IDALKTNPEY | LEFKVSKKDT | VVNYKDWQIS | LSRRFRSLKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WMVLRLYGSE | NLRNFIRDHV | NLAKHFEDYV | AQDPSFEVVT | TRYFSLVCFR | LAPVDGDEDQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CNERNRELLA | AVNSTGKIFI | SHTALSGKFV | LRFAVGAPLT | EEKHVTEAWQ | IIQKHASKFT |
| RNDHY |