P16453

PR
Gene name
Hdc
Protein name
Histidine decarboxylase
Names
HDC
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
4.1.1.22: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P16453

Entry ID Method Resolution Chain Position Source
AF-P16453-F1 Predicted AlphaFoldDB

3 variants for P16453

Variant ID(s) Position Change Description Diseaes Association Provenance
8 H>R No
28 V>L No
286 R>C No

No associated diseases with P16453

1 regional properties for P16453

Type Name Position InterPro Accession
binding_site Pyridoxal-phosphate binding site 301 - 322 IPR021115

Functions

Description
EC Number 4.1.1.22 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

5 GO annotations of molecular function

Name Definition
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
histidine decarboxylase activity Catalysis of the reaction: L-histidine = histamine + CO2.
identical protein binding Binding to an identical protein or proteins.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

5 GO annotations of biological process

Name Definition
catecholamine biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
histamine biosynthetic process The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
histamine metabolic process The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
histidine catabolic process The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
histidine metabolic process The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5EA83 HDC Histidine decarboxylase Bos taurus (Bovine) PR
P18486 amd 3,4-dihydroxyphenylacetaldehyde synthase Drosophila melanogaster (Fruit fly) PR
P05031 Ddc Aromatic-L-amino-acid decarboxylase Drosophila melanogaster (Fruit fly) PR
P19113 HDC Histidine decarboxylase Homo sapiens (Human) PR
P23738 Hdc Histidine decarboxylase Mus musculus (Mouse) PR
Q95ZS2 tdc-1 Tyrosine decarboxylase Caenorhabditis elegans PR
Q9M0G4 TYRDC Tyrosine decarboxylase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MMEPSEYHEY QARGKEMVDY ICQYLSTVRE RQVTPNVKPG YLRAQIPSSA PEEPDSWDSI
70 80 90 100 110 120
FGDIEQIIMP GVVHWQSPHM HAYYPALTSW PSLLGDMLAD AINCLGFTWA SSPACTELEM
130 140 150 160 170 180
NIMDWLAKML GLPDFFLHHH PSSQGGGVLQ RTVSESTLIA LLAARKNKIL EMKAHEPNAD
190 200 210 220 230 240
ESSLNARLVA YASDQAHSSV EKAGLISLVK IKFLPVDDNF SLRGEALQKA IEEDKQQGLV
250 260 270 280 290 300
PVFVCATLGT TGVCAFDKLS ELGPICAREG LWLHVDAAYA GTAFLRPELR GFLKGIEYAD
310 320 330 340 350 360
SFTFNPSKWM MVHFDCTGFW VKDKYKLQQT FSVNPIYLRH ANSGVATDFM HWQIPLSRRF
370 380 390 400 410 420
RSIKLWFVIR SFGVKNLQAH VRHGTDMAKY FESLVRSDPV FEIPAERHLG LVVFRLKGPN
430 440 450 460 470 480
CLTESVLKEI AKTGQVFLIP ATIQDKLIIR FTVTSQFTTK DDILRDWNLI REAANLVLSQ
490 500 510 520 530 540
HCTSQPSPRA KNLIPPPVTR DSKDLTNGLS LESVNEGGDD PVQVRKIFRL PGDSLETTMD
550 560 570 580 590 600
PFDDCFSEEA SDTTKHKLSS FLFSYLSVQN KKKTMRSLSC NSMPMSAQKS PPPDASVKHG
610 620 630 640 650
GFFRARIFSG FPEEMMMMKK GGFKKLIKFY SVPSFPECSS QCGTLQLPCC PLQAMV