AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

3-84 (Predicted disordered autoinhibitory region) PR

3-84 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P23738-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388589511	5	C>Y	No	EVA
rs250863567	8	R>C	No	EVA
rs579916796	8	R>H	No	EVA
rs234313608	11	R>C	No	EVA
rs218733566	11	R>H	No	EVA
rs228158724	27	Q>R	No	EVA
rs3388590986	33	R>G	No	EVA
rs3388592196	66	G>E	No	EVA
rs3392151036	79	W>GLCQ*	No	EVA
rs3392230297	81	S>N	No	EVA
rs3392096513	81	S>R	No	EVA
rs3392124427	82	P>T	No	EVA
rs3392199832	85	H>P	No	EVA
rs3388586254	123	E>V	No	EVA
rs218873215	177	K>T	No	EVA
rs3388585178	179	C>W	No	EVA
rs3388583616	182	D>E	No	EVA
rs244567518	187	S>F	No	EVA
rs215145978	187	S>T	No	EVA
rs3388581396	209	L>*	No	EVA
rs3388587498	219	P>T	No	EVA
rs3388585198	249	C>S	No	EVA
rs3388582066	250	A>G	No	EVA
rs3388583648	251	T>A	No	EVA
rs3388592158	252	L>F	No	EVA
rs3388583638	274	G>R	No	EVA
rs3388591801	316	V>I	No	EVA
rs3388592191	334	T>I	No	EVA
rs3388589517	335	F>S	No	EVA
rs3388591042	359	P>T	No	EVA
rs27421579	389	T>I	No	EVA
rs262391697	390	E>A	No	EVA
rs3388588872	441	F>L	No	EVA
rs248150629	496	N>D	No	EVA
rs230475908	503	G>V	No	EVA
rs235579062	546	P>L	No	EVA
rs3388581773	554	S>L	No	EVA
rs3388588673	567	S>F	No	EVA
rs3412845472	632	K>R	No	EVA
rs3388585235	639	V>D	No	EVA

Type	Name	Position	InterPro Accession
binding_site	Pyridoxal-phosphate binding site	305 - 326	IPR021115

		Description
EC Number	4.1.1.22	Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

Name	Definition
amino acid binding	Binding to an amino acid, organic acids containing one or more amino substituents.
carboxy-lyase activity	Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
histidine decarboxylase activity	Catalysis of the reaction: L-histidine = histamine + CO2.
identical protein binding	Binding to an identical protein or proteins.
pyridoxal phosphate binding	Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

Name	Definition
catecholamine biosynthetic process	The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
histamine biosynthetic process	The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
histamine metabolic process	The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
histidine catabolic process	The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
histidine metabolic process	The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5EA83	HDC	Histidine decarboxylase	Bos taurus (Bovine)	PR
P18486	amd	3,4-dihydroxyphenylacetaldehyde synthase	Drosophila melanogaster (Fruit fly)	PR
P05031	Ddc	Aromatic-L-amino-acid decarboxylase	Drosophila melanogaster (Fruit fly)	PR
P19113	HDC	Histidine decarboxylase	Homo sapiens (Human)	PR
P16453	Hdc	Histidine decarboxylase	Rattus norvegicus (Rat)	PR
Q95ZS2	tdc-1	Tyrosine decarboxylase	Caenorhabditis elegans	PR
Q9M0G4	TYRDC	Tyrosine decarboxylase 2	Arabidopsis thaliana (Mouse-ear cress)	PR