Q95ZS2
Gene name |
tdc-1 |
Protein name |
Tyrosine decarboxylase |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_K01C8.3 |
EC number |
4.1.1.25: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q95ZS2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q95ZS2-F1 | Predicted | AlphaFoldDB |
No variants for Q95ZS2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q95ZS2 | |||||
No associated diseases with Q95ZS2
1 regional properties for Q95ZS2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| binding_site | Pyridoxal-phosphate binding site | 373 - 394 | IPR021115 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.25 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| carboxy-lyase activity | Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| tyrosine decarboxylase activity | Catalysis of the reaction: L-tyrosine = tyramine + CO2. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular amino acid metabolic process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. |
| octopamine biosynthetic process | The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5EA83 | HDC | Histidine decarboxylase | Bos taurus (Bovine) | PR |
| P18486 | amd | 3,4-dihydroxyphenylacetaldehyde synthase | Drosophila melanogaster (Fruit fly) | PR |
| P05031 | Ddc | Aromatic-L-amino-acid decarboxylase | Drosophila melanogaster (Fruit fly) | PR |
| P19113 | HDC | Histidine decarboxylase | Homo sapiens (Human) | PR |
| P23738 | Hdc | Histidine decarboxylase | Mus musculus (Mouse) | PR |
| P16453 | Hdc | Histidine decarboxylase | Rattus norvegicus (Rat) | PR |
| Q9M0G4 | TYRDC | Tyrosine decarboxylase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVYGLGEALK | NLNSYCQERT | TRIRNSLSPS | RPSMSEATAT | GSSSSSRAST | TIPSTPNMDV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TPTVEDPRQN | DNNASGMTRD | EFRQYGKETV | DYIVDYLENI | QKRRVVPAIE | PGYLKDLIPS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EAPNTPESFE | SVMEDFEKLI | MPGITHWQHP | RFHAYFPAGN | SFPSIIADML | SDAIGCVGFS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WAACPAMTEL | ELIMLDWFGK | MIGLPAEFLP | LTENGKGGGV | IQSSASECNF | VTLLAARFEV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MKELRQRFPF | VEEGLLLSKL | IAYCSKEAHS | SVEKACMIGM | VKLRILETDS | KFRLRGDTLR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NAIQEDRNLG | LIPFFVSTTL | GTTSCCSFDV | LSEIGPICKE | NELWLHVDAA | YSGSAFICPE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FRPLMNGIEY | AMSFNTNPNK | WLLINFDCST | MWVRDRFKLT | QALVVDPLYL | QHSWMDKSID |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YRHWGIPLSR | RFRSLKLWFV | IRMYGIDGLQ | KYIREHVRLA | KKMETLLRAD | AKFEIVNEVI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MGLVCFRMKG | DDELNQTLLT | RLNASGRIHM | VPASLGDRFV | IRFCVCAENA | TDKDIEVAYE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IIAQATQHVL | HDSVKAVIAE | EDEEAVALEE | MVADLNITET | PEKCLTRQNS | ANAAESGQKL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ERQLSKEEIL | AQKQHESLAK | KRSFLVRMVS | DPKCYNPKIV | RHLNMANHRK | MSQDLYRDRT |
| 670 | 680 | 690 | 700 | ||
| LMQTISHSQR | PNRLSQSPGS | AGSAFFDDDD | DRIVADVQTG | LQTPI |