Q5EA83

PR
Gene name
HDC
Protein name
Histidine decarboxylase
Names
HDC
Species
Bos taurus (Bovine)
KEGG Pathway
bta:515950
EC number
4.1.1.22: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

450-630 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5EA83

Entry ID Method Resolution Chain Position Source
AF-Q5EA83-F1 Predicted AlphaFoldDB

116 variants for Q5EA83

Variant ID(s) Position Change Description Diseaes Association Provenance
rs469111024 12 K>R No EVA
rs445802716 13 E>* No EVA
rs432189875 13 E>D No EVA
rs446531210 14 M>I No EVA
rs466487100 14 M>K No EVA
rs481179132 15 V>E No EVA
rs481179132 15 V>G No EVA
rs460865210 16 D>E No EVA
rs450469844 17 Y>H No EVA
rs482584537 18 I>S No EVA
rs439010203 19 C>* No EVA
rs480039782 23 T>N No EVA
rs442861328 25 V>G No EVA
rs721013179 28 R>W No EVA
rs474333810 29 R>G No EVA
rs134024651 30 V>G No EVA
rs443664565 31 T>A No EVA
rs475496854 31 T>N No EVA
rs443664565 31 T>S No EVA
rs475496854 31 T>S No EVA
rs432126503 32 P>A No EVA
rs467540196 33 D>E No EVA
rs436042672 33 D>G No EVA
rs453094898 33 D>H No EVA
rs481851082 34 V>A No EVA
rs481851082 34 V>E No EVA
rs481851082 34 V>G No EVA
rs450393094 34 V>L No EVA
rs465644885 35 R>G No EVA
rs445532668 36 P>A No EVA
rs463905005 38 Y>* No EVA
rs480771126 38 Y>C No EVA
rs443015213 38 Y>D No EVA
rs443015213 38 Y>H No EVA
rs480771126 38 Y>S No EVA
rs443580131 39 L>P No EVA
rs471634644 40 R>G No EVA
rs384557664 40 R>Q No EVA
rs211220703 41 A>S No EVA
rs211220703 41 A>T No EVA
rs453031677 42 Q>P No EVA
rs436233997 43 L>P No EVA
rs457053050 45 E>Q No EVA
rs436913431 46 S>R No EVA
rs464927683 47 A>G No EVA
rs444859101 49 M>L No EVA
rs480062561 50 E>G No EVA
rs466530869 51 P>A No EVA
rs480884844 52 D>G No EVA
rs449385901 52 D>H No EVA
rs450064289 53 S>I No EVA
rs463794201 53 S>R No EVA
rs478122572 53 S>R No EVA
rs441217207 55 D>E No EVA
rs457936221 55 D>G No EVA
rs473103463 56 S>T No EVA
rs459682410 58 F>V No EVA
rs473999320 65 I>N No EVA
rs473999320 65 I>S No EVA
rs457091169 67 P>H No EVA
rs471494935 68 G>A No EVA
rs457057565 148 S>N No EVA
rs1116923293 175 E>K No EVA
rs445546273 204 S>F No EVA
rs463568112 209 K>E No EVA
rs443302185 213 V>M No EVA
rs471475781 219 L>R No EVA
rs516374713 223 A>G No EVA
rs451281119 223 A>S No EVA
rs440834469 237 V>L No EVA
rs455993065 238 P>A No EVA
rs435871425 239 I>F No EVA
rs456577025 240 F>S No EVA
rs459097133 263 C>W No EVA
rs445290788 265 R>S No EVA
rs479971250 266 E>* No EVA
rs459745666 267 G>R No EVA
rs474691535 273 D>E No EVA
rs461107528 276 Y>* No EVA
rs444317913 280 A>P No EVA
rs452222603 281 F>L No EVA
rs452917112 306 W>G No EVA
rs436005337 307 M>L No EVA
rs467390344 309 V>E No EVA
rs437494314 312 D>E No EVA
rs457595461 312 D>G No EVA
rs465530900 313 C>S No EVA
rs465530900 313 C>Y No EVA
rs445439796 314 T>N No EVA
rs479946346 315 G>S No EVA
rs466139559 317 W>G No EVA
rs479573583 320 D>A No EVA
rs449530178 338 A>P No EVA
rs459551870 344 T>A No EVA
rs459551870 344 T>P No EVA
rs473941566 345 D>N No EVA
rs468005030 355 R>L No EVA
rs461949562 361 K>N No EVA
rs442714602 373 N>S No EVA
rs438532536 384 M>T No EVA
rs472950266 387 Y>N No EVA
rs452931265 405 H>P No EVA
rs465592641 416 P>H No EVA
rs479722882 419 L>P No EVA
rs466002313 423 V>L No EVA
rs481344163 427 I>M No EVA
rs449234851 427 I>V No EVA
rs450788759 431 G>C No EVA
rs459325101 489 N>T No EVA
rs441984734 512 A>T No EVA
rs440222187 549 F>L No EVA
rs473849935 604 S>T No EVA
rs457532666 605 S>A No EVA
rs437505609 606 S>A No EVA
rs451842722 637 N>I No EVA
rs434836090 650 P>T No EVA

No associated diseases with Q5EA83

2 regional properties for Q5EA83

Type Name Position InterPro Accession
domain Peptidase family M60 domain 533 - 880 IPR031161
domain M60-like domain, N-terminal 518 - 623 IPR035423

Functions

Description
EC Number 4.1.1.22 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
histidine decarboxylase activity Catalysis of the reaction: L-histidine = histamine + CO2.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

3 GO annotations of biological process

Name Definition
catecholamine biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
histamine biosynthetic process The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
histidine catabolic process The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P18486 amd 3,4-dihydroxyphenylacetaldehyde synthase Drosophila melanogaster (Fruit fly) PR
P05031 Ddc Aromatic-L-amino-acid decarboxylase Drosophila melanogaster (Fruit fly) PR
P19113 HDC Histidine decarboxylase Homo sapiens (Human) PR
P23738 Hdc Histidine decarboxylase Mus musculus (Mouse) PR
P16453 Hdc Histidine decarboxylase Rattus norvegicus (Rat) PR
Q95ZS2 tdc-1 Tyrosine decarboxylase Caenorhabditis elegans PR
Q9M0G4 TYRDC Tyrosine decarboxylase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MMEPEEYRER GKEMVDYICQ YLTTVRERRV TPDVRPGYLR AQLPESAPME PDSWDSIFGD
70 80 90 100 110 120
IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN CLGFTWASSP ACTELEMNVM
130 140 150 160 170 180
DWLAKMLGLP EHFLHHHPGS QGGGVLQSTV SESTLIALLA ARKNKILEMK ASEPEADESF
190 200 210 220 230 240
LNARLVAYAS DQAHSSVEKA GLISLVKMKF LPVDENFSLR GEALQKAIKE DRERGLVPIF
250 260 270 280 290 300
VCATLGTTGV CAFDCLSELG PICAREGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT
310 320 330 340 350 360
FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV DPVYLRHADS GVATDFMHWQ IPLSRRFRSI
370 380 390 400 410 420
KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPFFEI PAKRHLGLVV FRLKGPNCLT
430 440 450 460 470 480
ESVLKEIAKA GRLFLIPATI QDKLIIRFTV TSQFTTRDDI LRDWNLIQDA ATLILSQHCT
490 500 510 520 530 540
SQPSPQGANL ILQTRGPRAL AKEMSFPSVN GAGDDPAHSR KIVMQPPRVG ASPVSRHLET
550 560 570 580 590 600
LLDPLDDCFS EEAPDVTEHK LSSFLFSYLS VQNKRKAVRS LSCNSVPVSA QKQLTTEGSV
610 620 630 640 650
KNGSSSRVRI FSRFPEEVMM LKKSAFKKLI KFYSVPNFPE CSSQCGLQLP CCPLQAMV