P18486

PR
Gene name
amd (l(2)amd, CG10501)
Protein name
3,4-dihydroxyphenylacetaldehyde synthase
Names
DHPAA synthase, isoform A, Alpha-methyldopa hypersensitive protein
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG10501
EC number
4.1.1.107: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

443-510 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P18486

Entry ID Method Resolution Chain Position Source
6JRL X-ray 220 A A 1-510 PDB
AF-P18486-F1 Predicted AlphaFoldDB

No variants for P18486

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P18486

No associated diseases with P18486

1 regional properties for P18486

Type Name Position InterPro Accession
binding_site Pyridoxal-phosphate binding site 296 - 317 IPR021115

Functions

Description
EC Number 4.1.1.107 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aromatic-L-amino-acid decarboxylase activity Catalysis of the reaction: L-amino acid + H+ = R-H + CO2.
carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
L-dopa decarboxylase activity Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
structural constituent of cuticle The action of a molecule that contributes to the structural integrity of a cuticle.

5 GO annotations of biological process

Name Definition
catecholamine catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
catecholamine metabolic process The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
chitin-based cuticle development Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.
cuticle development The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5EA83 HDC Histidine decarboxylase Bos taurus (Bovine) PR
P05031 Ddc Aromatic-L-amino-acid decarboxylase Drosophila melanogaster (Fruit fly) PR
P19113 HDC Histidine decarboxylase Homo sapiens (Human) PR
P23738 Hdc Histidine decarboxylase Mus musculus (Mouse) PR
P16453 Hdc Histidine decarboxylase Rattus norvegicus (Rat) PR
Q95ZS2 tdc-1 Tyrosine decarboxylase Caenorhabditis elegans PR
Q9M0G4 TYRDC Tyrosine decarboxylase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDAKEFREFG KAAIDYIADY LENIRDDDVL PNVEPGYLLD LLPTEMPEEP EAWKDVLGDI
70 80 90 100 110 120
SRVIKPGLTH WQSPHMHAYY PTSTSYPSIV GEMLASGFGV IGFSWICSPA CTELEVVVMD
130 140 150 160 170 180
WLAKFLKLPA HFQHASDGPG GGVIQGSASE AVLVAVLAAR EQAVANYRES HPELSESEVR
190 200 210 220 230 240
GRLVAYSSDQ SNSCIEKAGV LAAMPIRLLP AGEDFVLRGD TLRGAIEEDV AAGRIPVICV
250 260 270 280 290 300
ATLGTTGTCA YDDIESLSAV CEEFKVWLHV DAAYAGGAFA LEECSDLRKG LDRVDSLNFN
310 320 330 340 350 360
LHKFMLVNFD CSAMWLRDAN KVVDSFNVDR IYLKHKHEGQ SQIPDFRHWQ IPLGRRFRAL
370 380 390 400 410 420
KVWITFRTLG AEGLRNHVRK HIELAKQFEQ LVLKDSRFEL VAPRALGLVC FRPKGDNEIT
430 440 450 460 470 480
TQLLQRLMDR KKIYMVKAEH AGRQFLRFVV CGMDTKASDI DFAWQEIESQ LTDLQAEQSL
490 500
VARKSGNVGD LAQHFQIHLS TENATHEKSQ