P05031
PR
Gene name |
Ddc (CG10697) |
Protein name |
Aromatic-L-amino-acid decarboxylase |
Names |
AADC, DOPA decarboxylase, DDC |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG10697 |
EC number |
4.1.1.28: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P05031
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3K40 | X-ray | 175 A | A/B | 36-510 | PDB |
| AF-P05031-F1 | Predicted | AlphaFoldDB |
6 variants for P05031
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 12 | T>P | allele Ddc-R6, allele Ddc-R9, allele Ddc-R16, allele Ddc-R20, allele Ddc-R25 and allele Ddc-R30 [UniProt] | No | ||
| 197 | K>N | allele Ddc-R9 [UniProt] | No | ||
| 264 | V>M | allele Ddc-R11 and allele Ddc-R18 [UniProt] | No | ||
| 390 | R>M | allele Ddc-Ore [UniProt] | No | ||
| 428 | S>F | allele Ddc-R33 [UniProt] | No | ||
| 489 | S>A | allele Ddc-2b [UniProt] | No |
No associated diseases with P05031
1 regional properties for P05031
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| binding_site | Pyridoxal-phosphate binding site | 330 - 351 | IPR021115 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.28 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5-hydroxy-L-tryptophan decarboxylase activity | Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin. |
| aromatic-L-amino-acid decarboxylase activity | Catalysis of the reaction: L-amino acid + H+ = R-H + CO2. |
| carboxy-lyase activity | Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. |
| L-dopa decarboxylase activity | Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| adult chitin-containing cuticle pigmentation | Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster. |
| anesthesia-resistant memory | The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis. |
| catecholamine metabolic process | The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. |
| dopamine biosynthetic process from tyrosine | The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine. |
| long-term memory | The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. |
| regulation of adult chitin-containing cuticle pigmentation | Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. |
| response to hydrogen peroxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| response to wounding | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
| serotonin biosynthetic process | The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. |
| serotonin biosynthetic process from tryptophan | The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. |
| thermosensory behavior | Behavior that is dependent upon the sensation of temperature. |
| thermotaxis | The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature. |
| wing disc development | Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5EA83 | HDC | Histidine decarboxylase | Bos taurus (Bovine) | PR |
| P18486 | amd | 3,4-dihydroxyphenylacetaldehyde synthase | Drosophila melanogaster (Fruit fly) | PR |
| P19113 | HDC | Histidine decarboxylase | Homo sapiens (Human) | PR |
| P23738 | Hdc | Histidine decarboxylase | Mus musculus (Mouse) | PR |
| P16453 | Hdc | Histidine decarboxylase | Rattus norvegicus (Rat) | PR |
| Q95ZS2 | tdc-1 | Tyrosine decarboxylase | Caenorhabditis elegans | PR |
| Q9M0G4 | TYRDC | Tyrosine decarboxylase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSHIPISNTI | PTKQTDGNGK | ANISPDKLDP | KVSIDMEAPE | FKDFAKTMVD | FIAEYLENIR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ERRVLPEVKP | GYLKPLIPDA | APEKPEKWQD | VMQDIERVIM | PGVTHWHSPK | FHAYFPTANS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YPAIVADMLS | GAIACIGFTW | IASPACTELE | VVMMDWLGKM | LELPAEFLAC | SGGKGGGVIQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTASESTLVA | LLGAKAKKLK | EVKELHPEWD | EHTILGKLVG | YCSDQAHSSV | ERAGLLGGVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LRSVQSENHR | MRGAALEKAI | EQDVAEGLIP | FYAVVTLGTT | NSCAFDYLDE | CGPVGNKHNL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WIHVDAAYAG | SAFICPEYRH | LMKGIESADS | FNFNPHKWML | VNFDCSAMWL | KDPSWVVNAF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NVDPLYLKHD | MQGSAPDYRH | WQIPLGRRFR | ALKLWFVLRL | YGVENLQAHI | RRHCNFAKQF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GDLCVADSRF | ELAAEINMGL | VCFRLKGSNE | RNEALLKRIN | GRGHIHLVPA | KIKDVYFLRM |
| 490 | 500 | ||||
| AICSRFTQSE | DMEYSWKEVS | AAADEMEQEQ |