Q9ERI6
Gene name |
Rdh14 (Pan2) |
Protein name |
Retinol dehydrogenase 14 |
Names |
Alcohol dehydrogenase PAN2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:105014 |
EC number |
1.1.1.300: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9ERI6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9ERI6-F1 | Predicted | AlphaFoldDB |
9 variants for Q9ERI6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs217567570 | 21 | A>V | No | EVA | |
| rs234755471 | 86 | G>R | No | EVA | |
| rs3389217235 | 164 | L>Q | No | EVA | |
| rs3389230670 | 173 | L>P | No | EVA | |
| rs3389241659 | 190 | S>P | No | EVA | |
| rs4229244 | 207 | Q>H | No | EVA | |
| rs3389222987 | 276 | T>I | No | EVA | |
| rs3389193351 | 281 | A>T | No | EVA | |
| rs3389239238 | 300 | Y>* | No | EVA |
No associated diseases with Q9ERI6
No regional properties for Q9ERI6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9ERI6 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.300 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 11-cis-retinol dehydrogenase activity | Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+. |
| alcohol dehydrogenase (NADP+) activity | Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. |
| NADP-retinol dehydrogenase activity | Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| retinol metabolic process | The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53878 | YNL181W | Uncharacterized oxidoreductase YNL181W | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9VLU5 | Wwox | WW domain-containing oxidoreductase | Drosophila melanogaster (Fruit fly) | PR |
| P16152 | CBR1 | Carbonyl reductase [NADPH] 1 | Homo sapiens (Human) | PR |
| O75828 | CBR3 | Carbonyl reductase [NADPH] 3 | Homo sapiens (Human) | PR |
| A6NN90 | C2orf81 | Uncharacterized protein C2orf81 | Homo sapiens (Human) | PR |
| Q9NZC7 | WWOX | WW domain-containing oxidoreductase | Homo sapiens (Human) | PR |
| Q9HBH5 | RDH14 | Retinol dehydrogenase 14 | Homo sapiens (Human) | PR |
| Q8CEE7 | Rdh13 | Retinol dehydrogenase 13 | Mus musculus (Mouse) | PR |
| Q9DAQ4 | Uncharacterized protein C2orf81 homolog | Mus musculus (Mouse) | PR | |
| Q91WL8 | Wwox | WW domain-containing oxidoreductase | Mus musculus (Mouse) | PR |
| Q6AXP4 | Uncharacterized protein C2orf81 homolog | Rattus norvegicus (Rat) | PR | |
| A2RVM0 | TIC32 | Short-chain dehydrogenase TIC 32, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q803A8 | wwox | WW domain-containing oxidoreductase | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVASVAAAL | LAALGGALWL | AARRFSGPRN | QRQQGGGDPG | LMHGKTVLIT | GANSGLGRAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AAELLRLGAR | VIMGCRDRAR | AEEAAGQLRQ | ELCQAGGAGP | DGTDGQLVVK | ELDLASLRSV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RAFCQELLQE | EPRLDVLINN | AGVFHCPYTK | TEDGFEMQFG | VNHLGHFLLT | NLLLGLLKSS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| APSRIVVVSS | KLYKYGEINF | EDLNSEQSYN | KSFCYSRSKL | ANILFTRELA | RRLEGTNVTV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NVLHPGIVRT | NLGRHIHIPL | LARPLFNLVS | WAFFKTPLEG | AQTSIYLACS | PDVEGVSGRY |
| 310 | 320 | 330 | |||
| FGDCKEEELL | PKAMDESVAR | KLWDISEVMV | GILK |