P53878

PR
Gene name
YNL181W (N1640)
Protein name
Uncharacterized oxidoreductase YNL181W
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YNL181W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

333-407 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P53878

Entry ID Method Resolution Chain Position Source
AF-P53878-F1 Predicted AlphaFoldDB

6 variants for P53878

Variant ID(s) Position Change Description Diseaes Association Provenance
s14-298399 21 Q>H No SGRP
s14-298433 33 T>A No SGRP
s14-298899 188 S>N No SGRP
s14-299039 235 S>G No SGRP
s14-299155 273 M>I No SGRP
s14-299517 394 N>S No SGRP

No associated diseases with P53878

No regional properties for P53878

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P53878

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

1 GO annotations of molecular function

Name Definition
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VLU5 Wwox WW domain-containing oxidoreductase Drosophila melanogaster (Fruit fly) PR
Q9NZC7 WWOX WW domain-containing oxidoreductase Homo sapiens (Human) PR
Q9HBH5 RDH14 Retinol dehydrogenase 14 Homo sapiens (Human) PR
Q91WL8 Wwox WW domain-containing oxidoreductase Mus musculus (Mouse) PR
Q9ERI6 Rdh14 Retinol dehydrogenase 14 Mus musculus (Mouse) PR
A2RVM0 TIC32 Short-chain dehydrogenase TIC 32, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q803A8 wwox WW domain-containing oxidoreductase Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPLNIIGTAL LDGTDKIPYY QTIKKVAPYV LATGAIKYWS RGPSNTWERK LHGKVYLVTG
70 80 90 100 110 120
ATSQGMGTSV AYKMAELGAQ LIILTREVDE WVTEWCEELR EKTKNELIFV EKCDLSNLWE
130 140 150 160 170 180
IRKFATSWLD NSPPRRLDGV IVMSGDMEPW GIPKISLPQR RSSKDGLELQ IATNYVAIFH
190 200 210 220 230 240
LLNLLQPSFK AQPPDRDVRI ILATCWLQVV GDINIEDPLW QNAKYKSALK FFASSKLQLG
250 260 270 280 290 300
LSMMELQRRL TEDIKNQKTN GAERTGKNVT ITMVQPGTMR SNSLRRVISN GSVVLLIILY
310 320 330 340 350 360
CILLYPILWL FTKSGRRGDQ SFLYALMTPE LEEVNLKDTK VKYISDCSIV KFARKEFDDE
370 380 390 400
ELQKKLFDNT ERDILQLEKK VAAKRNANKT GNQNSKKKSQ NKSRKDD