Q803A8
Gene name |
wwox |
Protein name |
WW domain-containing oxidoreductase |
Names |
|
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:393887 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q803A8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q803A8-F1 | Predicted | AlphaFoldDB |
No variants for Q803A8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q803A8 | |||||
No associated diseases with Q803A8
3 regional properties for Q803A8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | WW domain | 16 - 49 | IPR001202-1 |
| domain | WW domain | 57 - 90 | IPR001202-2 |
| domain | WWOX, classical (c)-like SDR domain | 121 - 404 | IPR042732 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cellular calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53878 | YNL181W | Uncharacterized oxidoreductase YNL181W | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9VLU5 | Wwox | WW domain-containing oxidoreductase | Drosophila melanogaster (Fruit fly) | PR |
| P16152 | CBR1 | Carbonyl reductase [NADPH] 1 | Homo sapiens (Human) | PR |
| O75828 | CBR3 | Carbonyl reductase [NADPH] 3 | Homo sapiens (Human) | PR |
| A6NN90 | C2orf81 | Uncharacterized protein C2orf81 | Homo sapiens (Human) | PR |
| Q9HBH5 | RDH14 | Retinol dehydrogenase 14 | Homo sapiens (Human) | PR |
| Q9NZC7 | WWOX | WW domain-containing oxidoreductase | Homo sapiens (Human) | PR |
| Q8CEE7 | Rdh13 | Retinol dehydrogenase 13 | Mus musculus (Mouse) | PR |
| Q9ERI6 | Rdh14 | Retinol dehydrogenase 14 | Mus musculus (Mouse) | PR |
| Q9DAQ4 | Uncharacterized protein C2orf81 homolog | Mus musculus (Mouse) | PR | |
| Q91WL8 | Wwox | WW domain-containing oxidoreductase | Mus musculus (Mouse) | PR |
| Q6AXP4 | Uncharacterized protein C2orf81 homolog | Rattus norvegicus (Rat) | PR | |
| A2RVM0 | TIC32 | Short-chain dehydrogenase TIC 32, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAALKYAGME | DTDSEDELPP | GWEERSTKDG | WVYYANHEEM | KTQWEHPKTG | KKKRCAGALP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YGWEQETDDK | GQIFYVDHIN | KRKTYFDPRQ | AFTVEDMQVK | PKRYDGNTGA | LEILHGQDLS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DKVIIVTGAN | SGIGFETARS | FALHGAHVIL | ACRNQSRASK | AASLIMGEWS | KARVEVLPLD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LASLRSVRQF | AELFKATKLP | LHVLVCNAAV | CSQPWRLTED | GFESTFQICH | LGHFLLVQLL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QDVLRLSAPA | RVVVVSSESH | RFTDLLDSCG | NLDLDLLSPP | QKNYWSLLAY | NRAKLCNLLF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SSELHRRMSP | HGICCNALHP | GSMMFTSIHR | SWWLLTLLFS | LARPFTKSMQ | QGAATTVYCA |
| 370 | 380 | 390 | 400 | 410 | |
| VAPELEGIGG | MYFNNCFRCL | PSPQAQDPAA | ALSLWELSER | LVQERSTPPQ | VL |