A2RVM0
Gene name |
TIC32 |
Protein name |
Short-chain dehydrogenase TIC 32, chloroplastic |
Names |
Translocon at the inner envelope membrane of chloroplasts 32, AtTIC32 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G23430 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2RVM0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2RVM0-F1 | Predicted | AlphaFoldDB |
36 variants for A2RVM0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_12229177_T_G | 3 | F>V | No | 1000Genomes | |
| ENSVATH14286832 | 5 | G>* | No | 1000Genomes | |
| ENSVATH02915539 | 9 | A>V | No | 1000Genomes | |
| ENSVATH06759786 | 25 | V>I | No | 1000Genomes | |
| ENSVATH06759789 | 39 | S>N | No | 1000Genomes | |
| tmp_4_12230048_A_C | 45 | T>P | No | 1000Genomes | |
| ENSVATH12174125 | 48 | V>I | No | 1000Genomes | |
| tmp_4_12230067_T_A | 51 | L>Q | No | 1000Genomes | |
| tmp_4_12230069_C_T | 52 | R>C | No | 1000Genomes | |
| tmp_4_12230091_C_G | 59 | A>G | No | 1000Genomes | |
| ENSVATH12174126 | 63 | T>S | No | 1000Genomes | |
| ENSVATH02915550 | 71 | E>K | No | 1000Genomes | |
| ENSVATH02915551 | 77 | V>I | No | 1000Genomes | |
| tmp_4_12230158_A_T | 81 | K>N | No | 1000Genomes | |
| tmp_4_12230159_C_T | 82 | L>F | No | 1000Genomes | |
| tmp_4_12230165_G_A | 84 | V>I | No | 1000Genomes | |
| ENSVATH02915552 | 95 | V>L | No | 1000Genomes | |
| ENSVATH06759790 | 99 | A>T | No | 1000Genomes | |
| tmp_4_12230226_C_T | 104 | S>F | No | 1000Genomes | |
| tmp_4_12230336_T_A | 115 | N>K | No | 1000Genomes | |
| tmp_4_12230374_A_G | 128 | D>G | No | 1000Genomes | |
| ENSVATH12174129 | 130 | I>F | No | 1000Genomes | |
| ENSVATH06759795 | 161 | R>* | No | 1000Genomes | |
| ENSVATH12174130 | 167 | N>S | No | 1000Genomes | |
| tmp_4_12230629_G_A | 174 | R>Q | No | 1000Genomes | |
| tmp_4_12230665_T_A | 186 | I>N | No | 1000Genomes | |
| tmp_4_12230675_G_C | 189 | K>N | No | 1000Genomes | |
| tmp_4_12230807_G_A | 209 | A>T | No | 1000Genomes | |
| ENSVATH06759796 | 211 | E>K | No | 1000Genomes | |
| tmp_4_12231149_T_A | 256 | I>K | No | 1000Genomes | |
| tmp_4_12231148_A_C | 256 | I>L | No | 1000Genomes | |
| tmp_4_12231362_T_A | 280 | S>T | No | 1000Genomes | |
| tmp_4_12231396_A_T | 291 | K>I | No | 1000Genomes | |
| ENSVATH06759800 | 298 | D>A | No | 1000Genomes | |
| tmp_4_12231422_G_C | 300 | E>Q | No | 1000Genomes | |
| ENSVATH12174175 | 316 | Q>K | No | 1000Genomes |
No associated diseases with A2RVM0
No regional properties for A2RVM0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A2RVM0 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| chloroplast inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53878 | YNL181W | Uncharacterized oxidoreductase YNL181W | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9VLU5 | Wwox | WW domain-containing oxidoreductase | Drosophila melanogaster (Fruit fly) | PR |
| P16152 | CBR1 | Carbonyl reductase [NADPH] 1 | Homo sapiens (Human) | PR |
| O75828 | CBR3 | Carbonyl reductase [NADPH] 3 | Homo sapiens (Human) | PR |
| A6NN90 | C2orf81 | Uncharacterized protein C2orf81 | Homo sapiens (Human) | PR |
| Q9HBH5 | RDH14 | Retinol dehydrogenase 14 | Homo sapiens (Human) | PR |
| Q9NZC7 | WWOX | WW domain-containing oxidoreductase | Homo sapiens (Human) | PR |
| Q9DAQ4 | Uncharacterized protein C2orf81 homolog | Mus musculus (Mouse) | PR | |
| Q8CEE7 | Rdh13 | Retinol dehydrogenase 13 | Mus musculus (Mouse) | PR |
| Q9ERI6 | Rdh14 | Retinol dehydrogenase 14 | Mus musculus (Mouse) | PR |
| Q91WL8 | Wwox | WW domain-containing oxidoreductase | Mus musculus (Mouse) | PR |
| Q6AXP4 | Uncharacterized protein C2orf81 homolog | Rattus norvegicus (Rat) | PR | |
| Q803A8 | wwox | WW domain-containing oxidoreductase | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWFFGSKGAS | GFSSRSTAEE | VTHGVDGTGL | TAIVTGASSG | IGVETARVLS | LRGVHVVMAV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RNTDSGAKVK | EDIVKQVPGA | KLDVMELDLS | SMQSVRKFAS | EYKSTGLPLN | LLINNAGIMA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CPFMLSKDNI | ELQFATNHLG | HFLLTKLLLD | TMKSTSRESK | REGRIVNLSS | EAHRFSYPEG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VRFDKINDKS | SYSSMRAYGQ | SKLCNVLHAN | ELTKQLKEDG | VNITANSLHP | GAIMTNLGRY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FNPYLAVAVG | AVAKYILKSV | PQGAATTCYV | ALNPQVAGVS | GEYFQDSNIA | KPLPLVKDTE |
| 310 | 320 | ||||
| LAKKVWDFST | KLTDSQSGES | SS |